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Modulation de la réponse immunitaire par des agonistes de la voie de signalisation TLR/IL-1R dans le modèle d'asthme

Abstract : In our experimental work focusing on the immunoregulation of the immune response in a model of asthma, we showed firstly that the basophils were activated by double-stranded RNA poly(A:U) and that this stimulation exacerbated asthmatic responses in vivo. We then investigated the modulation of asthmatic responses using natural and synthetic ligands of TLR/IL1R signaling pathway. The results showed that R848, a synthetic TLR7 agonist which promotes Th1 antiviral responses, and IL-33, which is known to favor Th2 responses, activated NKT cells whose rapid and modulated production of cytokines suggested that these cells might have a modulatory effect in asthma. We demonstrated that NKT cells have a regulatory function on development and activity of newly identified Th17 cells. Finally, we described the protective and suppressive effects induced by R848 in the model of asthma and showed that suppression effects were dependent on regulatory T cells and the TGF-β.
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https://tel.archives-ouvertes.fr/tel-00514490
Contributor : Catherine Slama <>
Submitted on : Thursday, September 2, 2010 - 3:42:46 PM
Last modification on : Friday, October 23, 2020 - 4:41:46 PM
Long-term archiving on: : Friday, December 3, 2010 - 2:45:04 AM

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  • HAL Id : tel-00514490, version 1

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L. Pham Van. Modulation de la réponse immunitaire par des agonistes de la voie de signalisation TLR/IL-1R dans le modèle d'asthme. Biochimie [q-bio.BM]. Université René Descartes - Paris V, 2010. Français. ⟨tel-00514490⟩

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