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Étude structurale du système d'efflux membranaire MexXY-OprM impliqué dans la résistance aux antibiotiques chez Pseudomonas aeruginosa

Abstract : The Gram-negative bacteria Pseudomonas aeruginosa is a notoriously opportunistic human pathogen mainly implied in hospital infection. It has been largely shown that this organism exhibits resistance to multiple antimicrobial agents, generally attributable to the expression of a membrane efflux pump called Mex (Multi-drug Efflux pump). A representative efflux pump consists in tripartite assembly : an outer membrane channel-forming protein of the OMF family (Outer Membrane Factor), an inner membrane drug-proton antiporter belonging to the RND transporter family (Resistance Nodulation Division) and a periplasmic protein of the MFP family (Membrane Fusion Protein) which consolidates the whole system. Mainly by X-ray crystallography method, the thesis focuses on the structurally uncharacterized MexXY-OprM efflux pump that is particular because of its specific resistance toward aminoglycoside antibiotic family.
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https://tel.archives-ouvertes.fr/tel-00512797
Contributor : Phan Gilles <>
Submitted on : Tuesday, August 31, 2010 - 4:04:46 PM
Last modification on : Friday, June 19, 2020 - 3:28:02 PM
Long-term archiving on: : Thursday, December 1, 2016 - 10:19:45 AM

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  • HAL Id : tel-00512797, version 1

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Gilles Phan. Étude structurale du système d'efflux membranaire MexXY-OprM impliqué dans la résistance aux antibiotiques chez Pseudomonas aeruginosa. Biochimie [q-bio.BM]. Université René Descartes - Paris V, 2008. Français. ⟨tel-00512797⟩

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