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Theses

Utilisation d'un modèle microdosimétrique cinétique (MKM) pour l'interprétation d'irradiations cellulaires dans le cadre de l'hadronthérapie : Application de simulations Monte‐Carlo.

Abstract : Hadrontherapy is a cancer treatment method based on the use of heavy charged particles. The physical characteristics of these particles allow more precise targeting of tumours and offer higher biological efficiency than photons and electrons. This thesis addresses the problem of modelling the biological effects induced by such particles. One part of this work is devoted to the analysis of the Monte‐Carlo simulation toolkit ʺGeant4ʺ used to simulate the physical stage of the particle interactions with the biological medium. We evaluated the ability of ʺGeant4ʺ to simulate the microscopic distribution of energy deposition produced by charged particles and we compared these results with those of another simulation code dedicated to radiobiological applications. The other part of the work is dedicated to the study of two radiobiological models that are the LEM (Local Effect Model) based on an amorphous track structure approach and the MKM (Microdosimetric Kinetic Model) based on microdosimetric approach. A theoretical analysis of both models and a comparison of their concepts are presented. Then we focused on a detailed analysis of the microdosimetric model ʺMKMʺ. Finally, we applied the MKM to reproduce the experimental results obtained at GANIL by irradiation of two tumour cell lines (cell line SCC61 and SQ20B) of different radiosensitivity with carbon and argon ions.
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https://tel.archives-ouvertes.fr/tel-00504039
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Submitted on : Monday, July 19, 2010 - 4:20:40 PM
Last modification on : Tuesday, November 19, 2019 - 2:43:10 AM
Long-term archiving on: : Friday, October 22, 2010 - 4:19:42 PM

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  • HAL Id : tel-00504039, version 1

Citation

Djamel Dabli. Utilisation d'un modèle microdosimétrique cinétique (MKM) pour l'interprétation d'irradiations cellulaires dans le cadre de l'hadronthérapie : Application de simulations Monte‐Carlo.. Biophysique [physics.bio-ph]. Université Blaise Pascal - Clermont-Ferrand II, 2010. Français. ⟨tel-00504039⟩

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