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Analyse des écoulements micro-vasculaires cérébraux

Abstract : This work is concerned with the hydrodynamics of blood flow in micro-vascular cerebral networks. The micro-vascular networks are reconstructed from specimens using high resolution three-dimensional micro tomography imaging and post-processing techniques. A numerical quasi-static approximation of blood flow is then developed. This approach allows to account for both the complex geometric structure of micro-vascular networks and the non-local hydrodynamic interactions of red blood cells flowing within them. The proposed method permits the evaluation of pressure, hematocrit and flow distributions over cortical brain volumes of about ten cubic millimeters containing tens of thousands of vascular segments. A systematic analysis of blood rheology models demonstrate the importance of the choice of viscosity model, in contrast to the low impact of the phase separation on the flow, a phenomenon for which we also offer alternative model. Moreover, we analyse the the cerebral blood perfusion and the general organisation of cortical blood flow. We quantify the vascular regions that are essentially micro-vascular functional units under normal physiological conditions and assess their evolution and robustness in pathological contexts such as for cerebral micro-strokes.
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Submitted on : Friday, June 11, 2010 - 12:29:42 PM
Last modification on : Friday, October 23, 2020 - 4:41:13 PM
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  • HAL Id : tel-00491347, version 1



Romain Guibert. Analyse des écoulements micro-vasculaires cérébraux. Physique [physics]. Université Paul Sabatier - Toulouse III, 2009. Français. ⟨tel-00491347⟩



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