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Theses

Valorisation de remèdes traditionnels utiles dans le traitement de la ciguatéra dans le Pacifique

Abstract : Ciguatera Fish Poisoning (CFP) is an intoxication resulting from the ingestion of coral reef fish that has accumulated neurotoxins issued from dinoflagellates. A common form of ichytosarcotoxism in tropical and subtropical regions, it manifests a cohort of complex symptoms in humans. In the first part of this thesis, the effect of Pacific CTX-1B (P-CTX-1B) on the production of nitric oxide (NO) radical via the modulation of inducible NO synthase (iNOS) enzyme, has been investigated. The results obtained suggest for the first time the inflammatory aspect of CFP. Unlike Western treatments, which are mainly symptomatic, traditional medicine in the Pacific is known for its effectiveness with the use of many plants in the treatment of CFP. Consequently, the therapeutic evaluation of several plant extracts is described in the second part of this thesis. The third part concerns the selection of three of these extracts and the subsequent phtochemical work undertaken. This studies has led to the identification of three molecules, quercitrin, rosmarinic acid and agnuside. The detoxifying activity of rosmarinic acid has been patented.
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Submitted on : Wednesday, May 12, 2010 - 2:37:35 AM
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Shilpa Kumar-Roiné. Valorisation de remèdes traditionnels utiles dans le traitement de la ciguatéra dans le Pacifique. Sciences du Vivant [q-bio]. Université de la Nouvelle-Calédonie, 2009. Français. ⟨tel-00482925⟩

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