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Structuration des génomes par sélection indirecte de la variabilité mutationnelle : une approche de modélisation et de simulation

Abstract : In the long term, the evolutionary success of a lineage does not depend only on the fitness of its founders. It also depends on the ability of the descendants to pass on the ancestral genotype without deleterious mutations, while sometimes discovering beneficial mutations. An intermediate level of mutational variability can thus be indirectly selected. Here, by simulating genome evolution under both local mutations and large rearrangements, we show that genome structure is an important component of the variability level: gene number and, more surprisingly, the amount of non coding DNA are adjusted according to the mutation rate and to the deleteriousness of gene mutations. The emergence of such surprising couplings suggests that, aside from mutational biases and direct selective costs, genomes are also shaped by more indirect selective pressures.
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https://tel.archives-ouvertes.fr/tel-00482375
Contributor : Carole Knibbe <>
Submitted on : Monday, May 10, 2010 - 12:23:09 PM
Last modification on : Wednesday, July 8, 2020 - 12:42:14 PM
Long-term archiving on: : Thursday, September 16, 2010 - 1:21:25 PM

Identifiers

  • HAL Id : tel-00482375, version 1
  • PRODINRA : 248100

Citation

Carole Knibbe. Structuration des génomes par sélection indirecte de la variabilité mutationnelle : une approche de modélisation et de simulation. Modélisation et simulation. INSA de Lyon, 2006. Français. ⟨tel-00482375⟩

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