B. Hedlund, S. Huitron-resendiz, S. J. Henriksen, and J. G. Sutcliffe, 5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern, Biological Psychiatry, vol.58, issue.10, p.831, 2005.
DOI : 10.1016/j.biopsych.2005.05.012

I. M. Lattmann, S. Fernandez, B. Dunn, P. Parveen, D. C. Latmann et al., Novel 5-HT7 Ligands as Antidepressants: Automated Synthesis of NSubstituted- N-[1-Methyl-3-(4-Methylpiperidin-1-yl)propyl]-Arylsulfonamides, Letters in Drug Design & Discovery, vol.3, issue.1, p.49, 2006.
DOI : 10.2174/157018006775240935

S. J. Peroutka and T. A. Howell, The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors, Neuropharmacology, vol.33, issue.3-4, p.319, 1994.
DOI : 10.1016/0028-3908(94)90060-4

M. M. Rapport, A. A. Green, and I. H. Page, Crystalline Serotonin, Science, vol.108, issue.2804, p.329, 1948.
DOI : 10.1126/science.108.2804.329

P. Schoeffter, C. Ullmer, I. Bobirnac, G. Gabbiani, and H. Lubbert, Functional, endogenously expressed 5-hydroxytryptamine 5-ht7 receptors in human vascular smooth muscle cells, British Journal of Pharmacology, vol.370, issue.6, pp.993-76, 1996.
DOI : 10.1111/j.1476-5381.1996.tb16687.x

P. B. Hedlund, S. Huitron-resendiz, S. J. Henriksen, and J. G. Sutcliffe, 5-HT7 Receptor Inhibition and Inactivation Induce Antidepressantlike Behavior and Sleep Pattern, Biological Psychiatry, vol.58, issue.10, p.831, 2005.
DOI : 10.1016/j.biopsych.2005.05.012

A. Wesolowska, A. Nikiforuk, K. Stachowicz, and E. Tatarczynska, Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression, Neuropharmacology, vol.51, issue.3, p.578, 2006.
DOI : 10.1016/j.neuropharm.2006.04.017

E. Lattmann, I. M. Fernandez, S. Dunn, B. Parveen, P. Latmann et al., Novel 5-HT7 Ligands as Antidepressants: Automated Synthesis of NSubstituted- N-[1-Methyl-3-(4-Methylpiperidin-1-yl)propyl]-Arylsulfonamides, Letters in Drug Design & Discovery, vol.3, issue.1, p.49, 2006.
DOI : 10.2174/157018006775240935

G. D. Yu, Y. L. Liu, X. H. Jiang, S. Y. Guo, H. Q. Zhang et al., The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT7 receptor, Brain Research Bulletin, vol.54, issue.4, p.395, 2001.
DOI : 10.1016/S0361-9230(00)00462-7

M. C. Antle, M. D. Ogilvie, G. E. Pickard, and R. E. Mistlberger, Response of the Mouse Circadian System to Serotonin 1A/2/7 Agonists in vivo: Surprisingly Little, Journal of Biological Rhythms, vol.18, issue.2, p.145, 2003.
DOI : 10.1177/0748730403251805

J. Sprouse, L. Reynolds, X. Li, J. Braselton, and A. Schmidt, 8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production, Neuropharmacology, vol.46, issue.1, p.52, 2004.
DOI : 10.1016/j.neuropharm.2003.08.007

J. A. Terron and A. Falcon-neri, receptor mediating smooth muscle relaxation in canine cerebral arteries, British Journal of Pharmacology, vol.120, issue.3, p.609, 1999.
DOI : 10.1038/sj.bjp.0702580

I. T. Forbes, S. Douglas, A. D. Gribble, R. J. Ife, A. P. Lightfoot et al., SB-656104-A: A novel 5-HT7 receptor antagonist with improved In vivo properties, Bioorganic & Medicinal Chemistry Letters, vol.12, issue.22, p.3341, 2002.
DOI : 10.1016/S0960-894X(02)00690-X

J. Yoon, E. A. Yoo, J. Y. Kim, A. N. Pae, H. Rhim et al., Preparation of piperazine derivatives as 5-HT7 receptor antagonists, Bioorganic & Medicinal Chemistry, vol.16, issue.10, p.5405, 2008.
DOI : 10.1016/j.bmc.2008.04.023

P. Raubo, M. S. Beer, P. A. Hunt, I. T. Huscroft, C. London et al., Aminoalkyl phenyl sulfones???a novel series of 5-HT7 receptor ligands, Bioorganic & Medicinal Chemistry Letters, vol.16, issue.5, p.1255, 2006.
DOI : 10.1016/j.bmcl.2005.11.067

C. Kikuchi, H. Suzuki, T. Hiranuma, and M. Koyama, New tetrahydrobenzindoles as potent and selective 5-HT7 antagonists with increased In vitro metabolic stability, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.1, p.61, 2003.
DOI : 10.1016/S0960-894X(02)00842-9

C. Kikuchi, T. Hiranuma, and M. Koyama, Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: New Selective Ligands of the 5-HT7 Receptor, Bioorganic & Medicinal Chemistry Letters, vol.12, issue.18, p.2549, 2002.
DOI : 10.1016/S0960-894X(02)00485-7

M. L. Lopez-rodriguez, E. Porras, B. Benhamu, J. A. Ramos, M. J. Morcillo et al., First pharmacophoric hypothesis for 5-HT7 antagonism, Bioorganic & Medicinal Chemistry Letters, vol.10, issue.10, p.1097, 2000.
DOI : 10.1016/S0960-894X(00)00166-9

J. L. Neumeyer, G. W. Arana, V. J. Ram, N. S. Kula, and R. J. Baldessarini, Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine, Journal of Medicinal Chemistry, vol.25, issue.8, p.990, 1982.
DOI : 10.1021/jm00350a021

J. L. Neumeyer, D. Reischig, G. W. Arana, A. Campbell, R. J. Baldessarini et al., Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors, Journal of Medicinal Chemistry, vol.26, issue.4, p.516, 1983.
DOI : 10.1021/jm00358a011

Y. G. Gao, V. J. Ram, A. Campbell, N. S. Kula, R. J. Baldessarini et al., Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain, Journal of Medicinal Chemistry, vol.33, issue.1, p.39, 1990.
DOI : 10.1021/jm00163a007

M. H. Hedberg, A. M. Johansson, G. Nordvall, A. Yliniemela, H. B. Li et al., (R)-11-Hydroxy- and (R)-11-Hydroxy-10-methylaporphine: Synthesis, Pharmacology, and Modeling of D2A and 5-HT1A Receptor Interactions, Journal of Medicinal Chemistry, vol.38, issue.4, p.647, 1995.
DOI : 10.1021/jm00004a011

M. Paillet-loilier, F. Fabis, A. Lepailleur, R. Bureau, S. Butt-gueulle et al., Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands, Bioorganic & Medicinal Chemistry Letters, vol.15, issue.16, p.3753, 2005.
DOI : 10.1016/j.bmcl.2005.05.059

M. Paillet-loilier, F. Fabis, A. Lepailleur, R. Bureau, S. Butt-gueulle et al., Novel aminoethylbiphenyls as 5-HT7 receptor ligands, Bioorganic & Medicinal Chemistry Letters, vol.17, issue.11, p.3018, 2007.
DOI : 10.1016/j.bmcl.2007.03.054

URL : https://hal.archives-ouvertes.fr/hal-00865224

C. G. Thomson, M. S. Beer, N. R. Curtis, H. J. Diggle, E. Handford et al., Thiazoles and thiopyridines: novel series of high affinity h5HT7 ligands, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.3, p.677, 2004.
DOI : 10.1016/j.bmcl.2003.11.050

V. Parikh, W. M. Welch, and A. W. Schmidt, Discovery of a series of (4,5-Dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.2, p.269, 2003.
DOI : 10.1016/S0960-894X(02)00925-3

I. A. Cliffe, A retrospect on the discovery of way-100635 and the prospect for improved 5-HT1A receptor PET radioligands, Nuclear Medicine and Biology, vol.27, issue.5, p.441, 2000.
DOI : 10.1016/S0969-8051(00)00109-8

R. Perrone, F. Berardi, N. A. Colabufo, E. Lacivita, M. Leopoldo et al., Receptor Ligands, Journal of Medicinal Chemistry, vol.46, issue.4, p.646, 2003.
DOI : 10.1021/jm020994z

M. Leopoldo, E. Lacivita, M. Contino, N. A. Colabufo, F. Berardi et al., Receptor Agents. 2, Journal of Medicinal Chemistry, vol.50, issue.17, p.4214, 2007.
DOI : 10.1021/jm070487n

Y. H. Na, S. H. Hong, J. H. Lee, W. K. Park, D. J. Baek et al., Novel quinazolinone derivatives as 5-HT7 receptor ligands, Bioorganic & Medicinal Chemistry, vol.16, issue.5, p.2570, 2008.
DOI : 10.1016/j.bmc.2007.11.049

A. J. Bojarski, B. Duszynska, M. Kolaczkowski, P. Kowalski, and T. Kowalska, The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.23, p.5863, 2004.
DOI : 10.1016/j.bmcl.2004.09.029

M. H. Paluchowska, R. Bugno, B. Duszynska, E. Tatarczynska, A. Nikiforuk et al., The influence of modifications in imide fragment structure on 5-HT1A and 5-HT7 receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines, Bioorganic & Medicinal Chemistry, vol.15, issue.22, p.7116, 2007.
DOI : 10.1016/j.bmc.2007.07.029

I. T. Forbes, D. G. Cooper, E. K. Dodds, S. E. Douglas, A. D. Gribble et al., Identification of a novel series of selective 5-HT7 receptor antagonists, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.6, p.1055, 2003.
DOI : 10.1016/S0960-894X(03)00077-5

M. B. Isaac, T. Xin, A. O-'brien, D. St-martin, A. Naismith et al., 1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT7 receptor ligands, Bioorganic & Medicinal Chemistry Letters, vol.12, issue.17, p.2451, 2002.
DOI : 10.1016/S0960-894X(02)00438-9

R. J. Mattson, D. J. Denhart, J. D. Catt, M. F. Dee, J. A. Deskus et al., Aminotriazine 5-HT7 antagonists, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.16, p.4245, 2004.
DOI : 10.1016/j.bmcl.2004.06.008

D. J. Denhart, A. V. Purandare, J. D. Catt, H. D. King, A. Gao et al., Diaminopyrimidine and diaminopyridine 5-HT7 ligands, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.16, p.4249, 2004.
DOI : 10.1016/j.bmcl.2004.06.007

J. U. Peters, T. Lubbers, A. Alanine, S. Kolczewski, F. Blasco et al., Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration, Bioorganic & Medicinal Chemistry Letters, vol.18, issue.1, p.262, 2008.
DOI : 10.1016/j.bmcl.2007.10.078

E. S. Vermeulen, A. W. Schmidt, J. S. Sprouse, H. V. Wikstrom, and C. J. , Receptor Agonism and CoMFA-Based Modeling of the Agonist Binding Site, Journal of Medicinal Chemistry, vol.46, issue.25, p.5365, 2003.
DOI : 10.1021/jm030826m

G. Jones, P. Willett, and R. C. Glen, A genetic algorithm for flexible molecular overlay and pharmacophore elucidation, Journal of Computer-Aided Molecular Design, vol.7, issue.6, p.532, 1995.
DOI : 10.1007/BF00124324

P. Y. Lam, S. Deudon, K. M. Averill, R. Li, M. Y. He et al., Copper-Promoted C???N Bond Cross-Coupling with Hypervalent Aryl Siloxanes and Room-Temperature N-Arylation with Aryl Iodide, Journal of the American Chemical Society, vol.122, issue.31, p.7600, 2000.
DOI : 10.1021/ja001305g

D. R. Thomas, S. A. Gittins, L. L. Collin, D. N. Middlemiss, G. Riley et al., receptor (long form); antagonist profile of SB-258719, British Journal of Pharmacology, vol.46, issue.6, p.1300, 1998.
DOI : 10.1038/sj.bjp.0701946

Y. Hajbi, thèse soutenue publiquement le 22 Mars 2007 à l'Université d'Orléans, Formation Doctorale "Sciences et Technologies

F. Haenel, R. John, and G. Seitz, Trifluormethyl-substituierte, heterocyclisch anellierte Pyridine durch intramolekulareDiels-Alder-Cycloaddition mit inversem Elektronenbedarf, Archiv der Pharmazie, vol.321, issue.6, p.349, 1992.
DOI : 10.1002/ardp.19923250608

H. Morita and S. Shiotani, ]pyridines, Journal of Heterocyclic Chemistry, vol.26, issue.5, p.1465, 1986.
DOI : 10.1002/jhet.5570230542

W. Choi, I. N. Houpis, H. R. Churchill, A. Molina, J. E. Lynch et al., A practical synthesis of the 5-chloromethyl-furo[2,3-b]pyridine pharmacophore, Tetrahedron Letters, vol.36, issue.26, p.4571, 1995.
DOI : 10.1016/0040-4039(95)00850-C

P. Garner and J. M. Park, The synthesis and configurational stability of differentially protected .beta.-hydroxy-.alpha.-amino aldehydes, The Journal of Organic Chemistry, vol.52, issue.12, p.2361, 1987.
DOI : 10.1021/jo00388a004

J. G. Catalano, D. N. Deaton, E. S. Furfine, A. M. Hassell, R. B. Mcfadyen et al., Exploration of the P1 SAR of aldehyde cathepsin K inhibitors, Bioorganic & Medicinal Chemistry Letters, vol.14, issue.1, p.275, 2004.
DOI : 10.1016/j.bmcl.2003.09.088

K. Omura and D. Swern, Oxidation of alcohols by ???activated??? dimethyl sulfoxide. a preparative, steric and mechanistic study, Tetrahedron, vol.34, issue.11, p.1651, 1978.
DOI : 10.1016/0040-4020(78)80197-5

J. J. Barlow, M. H. Block, J. A. Hudson, A. Leach, J. L. Longridge et al., Acid catalyzed racemization of 1-(heterocyclyloxy)-2,3-propanediols, The Journal of Organic Chemistry, vol.57, issue.19, p.5158, 1992.
DOI : 10.1021/jo00045a030

M. S. Stanley, Orthogonally protected N3-(carboxymethyl)-L-2,3-diaminopropanoic acids and O-(carboxymethyl)-L-serines for solid-phase peptide synthesis, The Journal of Organic Chemistry, vol.57, issue.24, p.6421, 1992.
DOI : 10.1021/jo00050a013

S. Albrecht, A. Defoin, E. Salomon, C. Tarnus, and A. Wetterholm, Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors, Bioorganic & Medicinal Chemistry, vol.14, issue.21, p.7241, 2006.
DOI : 10.1016/j.bmc.2006.06.050

L. Bjoerk, B. B. Hoeoek, D. L. Nelson, N. E. Anden, and U. Hacksell, Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain, Journal of Medicinal Chemistry, vol.32, issue.4, p.779, 1989.
DOI : 10.1021/jm00124a009

C. Comoy, V. Guérin, B. Pfeiffer, M. Rettori, P. Renard et al., Substituted 3-amino and/or 3-aminomethyl-3,4-dihydro-2H-1-benzopyrans: synthesis and biological activity, Bioorganic & Medicinal Chemistry, vol.8, issue.3, p.483, 2000.
DOI : 10.1016/S0968-0896(99)00311-9

S. Ohira, Methanolysis of Dimethyl (1-Diazo-2-oxopropyl) Phosphonate: Generation of Dimethyl (Diazomethyl) Phosphonate and Reaction with Carbonyl Compounds, Synthetic Communications, vol.95, issue.3-4, p.561, 1989.
DOI : 10.1080/00397918908050700

G. Luppi, M. Villa, and C. Tomasini, Introduction of 4(S)-oxazolidineacetic acid, 2-oxo (D-Oxac) motif in a polypeptide chain: synthesis and conformational analysis, Organic & Biomolecular Chemistry, vol.1, issue.2, p.247, 2003.
DOI : 10.1039/b210725m

S. Fustero, J. Piera, J. F. Sanz-cervera, P. Bello, and N. Mateu, Synthesis of a new fluorinated oxazolidinone and its reactivity as a chiral auxiliary in Aldol reactions, Journal of Fluorine Chemistry, vol.128, issue.6, p.647, 2007.
DOI : 10.1016/j.jfluchem.2007.03.001

K. Itami, D. Yamazaki, and J. Yoshida, Pyrimidine-Core Extended ??-Systems:?? General Synthesis and Interesting Fluorescent Properties, Journal of the American Chemical Society, vol.126, issue.47, p.15396, 2004.
DOI : 10.1021/ja044923w

W. D. Wilson, L. Strekowski, F. A. Tanious, R. A. Watson, J. L. Mokrosz et al., Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation, Journal of the American Chemical Society, vol.110, issue.25, p.8292, 1988.
DOI : 10.1021/ja00233a003

P. Zajdel, G. Subra, A. J. Bojarski, B. Duszynska, M. Pawlowski et al., Parallel solid-phase synthesis and characterization of new sulfonamide and carboxamide proline derivatives as potential CNS agents, Bioorganic & Medicinal Chemistry, vol.13, issue.8, p.3029, 2005.
DOI : 10.1016/j.bmc.2005.01.060