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Contribution à la mesure de la rigidité artérielle par technique d'impédance bioélectrique : modélisation, instrumentation et traitement des signaux

Abstract : In the present thesis, we develop the bioelectrical impedance (BI) technique for the measurement of the arterial stiffness. The first part shows the recording of the impedance signal on several anatomical sites such as chest, pelvis, thigh and calf. The time-scale analysis of impedance signals on each anatomical site enables the time and spatial invariance to be validated. The study was performed on 15 healthy subjects. In the second part, we compare the impedance wave velocity (IWV) to the pulse wave velocity (PWV) for the determination of the aortic stiffness. The results show a high significant correlation between both techniques (r2=0.86 ; P<0.0001 with the Spearman coefficient) suggesting that the BI technique could give a reliable estimation of large artery stiffness. The major contributions of this technique are supported by its easiness to use and its independence from the subject's morphology and thus for a trained operator. The last part proposes a modeling of the impedance signal based on a new interpretation of the impedance signals. We establish the relationship between the variations of the impedance signals and the kinetic energy of the blood flow in large arteries. We develop three new indexes IRA, RP et PEPA for the determination of the local arterial stiffness. We observe a high correlation between the IRA index and PWV index r2=0.79 ; P<0.0001 with Pearson coefficient) on 50 patients at rest.
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  • HAL Id : tel-00467215, version 1

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Mathieu Collette. Contribution à la mesure de la rigidité artérielle par technique d'impédance bioélectrique : modélisation, instrumentation et traitement des signaux. Interface homme-machine [cs.HC]. Université d'Angers, 2009. Français. ⟨tel-00467215⟩

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