A. Tlvs and . Beis, Threshold limit values for chemical substances and physical agents and biological exposure indices American Conference of Governmental Industrial Hygienists, 2005.

G. Ahnström and K. Erixon, Measurement of strand breaks by alkaline denaturation and hydroxyapatite chromatography, DNA repair: A Laboratory Manuel Research Procedures, pp.403-421, 1981.

R. Albert, M. Miller, T. Cody, A. Andringa, R. Shukla et al., ??pyrene-induced skin damage and tumor promotion in the mouse, Carcinogenesis, vol.12, issue.7, pp.1273-80, 1991.
DOI : 10.1093/carcin/12.7.1273

B. Ames, J. Mccann, and E. Yamasaki, Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test, Mutation Research/Environmental Mutagenesis and Related Subjects, vol.31, issue.6, pp.347-64, 1975.
DOI : 10.1016/0165-1161(75)90046-1

S. Baek, R. Field, M. Goldstone, P. Kikk, J. Lester et al., A review of atmospheric polycyclic aromatic hydrocarbons: Sources, fate and behavior, Water, Air, and Soil Pollution, vol.16, issue.3-4, pp.3-4279, 1991.
DOI : 10.1007/BF00282628

A. Baulig, M. Garlatti, V. Bonvallot, A. Marchand, R. Barouki et al., Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.285, issue.3, 2003.
DOI : 10.1152/ajplung.00419.2002

A. Begleiter, D. Hewitt, A. Maksymiuk, D. Ross, and R. Bird, A NAD(P)H:Quinone Oxidoreductase 1 Polymorphism Is a Risk Factor for Human Colon Cancer, Cancer Epidemiology Biomarkers & Prevention, vol.15, issue.12, pp.2422-2428, 2006.
DOI : 10.1158/1055-9965.EPI-06-0661

S. Benhamou, W. Lee, A. Alexandrie, P. Boffetta, C. Bouchardy et al., Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk, Carcinogenesis, vol.23, issue.8, pp.1343-50, 2002.
DOI : 10.1093/carcin/23.8.1343

B. Binkova, Y. Giguere, P. Rossner, J. Dostal, M. Sram et al., The effect of dibenzo[a,l]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21WAF1 proteins and cell cycle distribution, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.471, issue.1-2, pp.57-70, 2000.
DOI : 10.1016/S1383-5718(00)00111-X

B. Binkova, J. Topinka, R. Sram, O. Sevastyanova, Z. Novakova et al., In vitro genotoxicity of PAH mixtures and organic extract from urban air particles, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.620, issue.1-2, pp.114-136, 2007.
DOI : 10.1016/j.mrfmmm.2007.03.001

P. Board, Biochemical genetics of glutathione-s-transferase in man, Pathology, vol.13, issue.1, pp.36-43, 1981.
DOI : 10.1016/S0031-3025(16)38444-6

K. Bock, H. Gschaidmeier, H. Heel, T. Lehmkoster, P. Munzel et al., Functions and transcriptional regulation of PAH-inducible human UDPglucuronosyltransferases . Drug metabolism reviews, pp.411-433, 1999.

S. Bonassi, A. Abbondandolo, L. Camurri, D. Pra, L. et al., Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study, Cancer Genetics and Cytogenetics, vol.79, issue.2, pp.133-138, 1995.
DOI : 10.1016/0165-4608(94)00131-T

C. Bosetti, P. Boffetta, L. Vecchia, and C. , Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to, 2005.

A. Bosveld, P. De-bie, N. Van-den-brink, H. Jongepier, and A. Klomp, In vitro EROD induction equivalency factors for the 10 PAHs generally monitored in risk assessment studies in The Netherlands, Chemosphere, vol.49, issue.1, pp.75-83, 2002.
DOI : 10.1016/S0045-6535(02)00161-3

E. Braithwaite, X. Wu, and Z. Wang, Repair of DNA lesions induced by polycyclic aromatic hydrocarbons in human cell-free extracts: involvement of two excision repair mechanisms in vitro, Carcinogenesis, vol.19, issue.7, pp.1239-1285, 1998.
DOI : 10.1093/carcin/19.7.1239

J. Briede, R. Godschalk, M. Emans, D. Kok, T. Van-agen et al., <emph type="2">In Vitro</emph> and <emph type="2">In Vivo</emph> Studies on Oxygen Free Radical and DNA Adduct Formation in Rat Lung and Liver during Benzo[a]pyrene Metabolism, Free Radical Research, vol.21, issue.9, pp.995-1002, 2004.
DOI : 10.1080/10715760400000976

T. Bucheli, F. Blum, A. Desaules, and O. Gustafsson, Polycyclic aromatic hydrocarbons, black carbon, and molecular markers in soils of Switzerland, Chemosphere, vol.56, issue.11, 2004.
DOI : 10.1016/j.chemosphere.2004.06.002

J. Buchet, M. Ferreira, J. Burrion, J. Leroy, T. Kirsch-volders et al., Tumor markers in serum, polyamines and modified nucleosides in urine, and cytogenetic aberrations in lymphocytes of workers exposed to polycyclic aromatic hydrocarbons, American Journal of Industrial Medicine, vol.10, issue.4, pp.523-566, 1995.
DOI : 10.1002/ajim.4700270406

J. Buchet, J. Gennart, F. Mercado-calderon, J. Delavignette, L. Cupers et al., Evaluation of exposure to polycyclic aromatic hydrocarbons in a coke production and a graphite electrode manufacturing plant: assessment of urinary excretion of 1-hydroxypyrene as a biological indicator of exposure., Occupational and Environmental Medicine, vol.49, issue.11, pp.761-769, 1992.
DOI : 10.1136/oem.49.11.761

M. Burczynski and T. Penning, Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor, Cancer Res Feb, vol.1560, issue.4, pp.908-923, 2000.

A. Burdick, J. Davis, K. Liu, L. Hudson, H. Shi et al., Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells, Cancer Res, vol.63, issue.22, pp.7825-7858, 2003.

A. Buschini, F. Cassoni, E. Anceschi, L. Pasini, P. Poli et al., Urban airborne particulate: genotoxicity evaluation of different size fractions by mutagenesis tests on microorganisms and comet assay, Chemosphere, vol.44, issue.8, pp.1723-1759, 2001.
DOI : 10.1016/S0045-6535(00)00550-6

E. Cavalieri and E. Rogan, The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation, Pharmacology & Therapeutics, vol.55, issue.2, pp.183-99, 1992.
DOI : 10.1016/0163-7258(92)90015-R

D. Cavallo, C. Ursini, D. Filippo, P. Ciervo, A. Spicaglia et al., Evaluation of Direct-Oxidative DNA Damage on Human Lung Epithelial Cells Exposed to Urban Airborne Particulate Matter Water Air Soil Pollut, pp.69-77, 2009.

M. Cerna, D. Pochmanova, A. Pastorkova, I. Benes, J. Lenicek et al., Genotoxicity of urban air pollutants in the Czech Republic, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.469, issue.1, pp.71-82, 2000.
DOI : 10.1016/S1383-5718(00)00062-0

K. Chaloupka, N. Harper, V. Krishnan, M. Santostefano, L. Rodriguez et al., Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists, Chemico-Biological Interactions, vol.89, issue.2-3, pp.2-3141, 1993.
DOI : 10.1016/0009-2797(93)90005-J

M. Chen, P. Tsai, and Y. Wang, Assessing inhalatory and dermal exposures and their resultant health-risks for workers exposed to polycyclic aromatic hydrocarbons (PAHs) contained in oil mists in a fastener manufacturing industry, Environment International, vol.34, issue.7, pp.971-976, 2008.
DOI : 10.1016/j.envint.2008.02.008

S. Chen, N. Nguyen, K. Tamura, M. Karin, and R. Tukey, The Role of the Ah Receptor and p38 in Benzo[a]pyrene-7,8-dihydrodiol and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced Apoptosis, Journal of Biological Chemistry, vol.278, issue.21, pp.19526-19559, 2003.
DOI : 10.1074/jbc.M300780200

K. Cheng, D. Cahill, H. Kasai, S. Nishimura, and L. Loeb, 8-Hydroxyguanine, an abundant form of oxidative DNA damageC substitutions, J Biol Chem, 1992.

S. Cherng, P. Lin, J. Yang, S. Hsu, and H. Lee, Benzo[g,h,i]perylene Synergistically Transactivates Benzo[a]pyrene-Induced CYP1A1 Gene Expression by Aryl Hydrocarbon Receptor Pathway, Toxicology and Applied Pharmacology, vol.170, issue.1, pp.63-71, 2001.
DOI : 10.1006/taap.2000.9082

M. Chu and C. Chen, Evaluation and estimation of potential carcinogenic risks of Polynuclear Aromatic Hydrocarbons. Symposiumon Polycyclic Aromatic Hydrocarbons in the workplace, 1984.

Y. Chun, M. Kim, and F. Guengerich, Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochemical and biophysical research communications, pp.20-24, 1999.

Y. Chun, S. Kim, D. Kim, S. Lee, and F. Guengerich, A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis, Cancer Res Nov, vol.1561, issue.22, pp.8164-70, 2001.

L. Claxton, P. Matthews, and S. Warren, The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity, Mutation Research/Reviews in Mutation Research, vol.567, issue.2-3, pp.347-99, 2004.
DOI : 10.1016/j.mrrev.2004.08.002

L. Claxton, A. Stead, and D. Walsh, An analysis by chemical class of Salmonella mutagenicity tests as predictors of animal carcinogenicity, Mutation Research/Genetic Toxicology, vol.205, issue.1-4, pp.1-4197, 1988.
DOI : 10.1016/0165-1218(88)90018-3

A. Cohen, Outdoor air pollution and lung cancer, Environmental health perspectives, 2000.

S. Cohen and L. Ellwein, Cell proliferation in carcinogenesis, Science, 1990.

L. Courter, A. Luch, T. Musafia-jeknic, V. Arlt, K. Fischer et al., The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo, Cancer Letters, vol.265, issue.1, pp.135-182, 2008.
DOI : 10.1016/j.canlet.2008.02.017

L. Courter, T. Musafia-jeknic, K. Fischer, R. Bildfell, J. Giovanini et al., Urban Dust Particulate Matter Alters PAH-Induced Carcinogenesis by Inhibition of CYP1A1 and CYP1B1, Toxicological Sciences, vol.95, issue.1, pp.63-73, 2007.
DOI : 10.1093/toxsci/kfl137

L. Courter, C. Pereira, and W. Baird, Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.625, issue.1-2, 2007.
DOI : 10.1016/j.mrfmmm.2007.05.005

H. Dally and A. Hartwig, Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells, Carcinogenesis, vol.18, issue.5, pp.1021-1027, 1997.
DOI : 10.1093/carcin/18.5.1021

D. Kok, T. Hogervorst, J. Briedé, J. Van-herwijnen, M. Maas et al., Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter, Environmental and Molecular Mutagenesis, vol.514, issue.2, pp.71-80, 2005.
DOI : 10.1002/em.20133

P. De-waard, D. Kok, T. Maas, L. Peijnenburg, A. Hoogenboom et al., Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line, Mutagenesis, vol.23, issue.1, pp.67-73, 2008.
DOI : 10.1093/mutage/gem046

D. R. Sienra, M. Rosazza, N. Préndez, and M. , Polycyclic aromatic hydrocarbons and their molecular diagnostic ratios in urban atmospheric respirable particulate matter, Atmospheric Environment, vol.75, issue.4, pp.267-81, 2005.

D. R. Sienra, T. , N. G. Rosazza, N. , M. Prendez et al., Polycyclic aromatic hydrocarbons and their molecular diagnostic ratios in urban atmospheric respirable particulate matter, Atmospheric Research, vol.75, issue.4, pp.267-81, 2005.
DOI : 10.1016/j.atmosres.2005.01.003

C. Delescluse, G. Lemaire, G. De-sousa, and R. Rahmani, Is CYP1A1 induction always related to AHR signaling pathway? Toxicology, Nov, vol.16153, pp.1-373, 2000.

L. Demaio and M. Corn, Polynuclear Aromatic Hydrocarbons Associated with Particulates in Pittsburgh Air, Journal of the Air Pollution Control Association, vol.16, issue.2, pp.67-71, 1966.
DOI : 10.1080/00022470.1966.10468443

D. Demarini, S. Landi, D. Tian, N. Hanley, X. Li et al., Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions, Fuel and Energy Abstracts, vol.43, issue.4, pp.616679-81, 2001.
DOI : 10.1016/S0140-6701(02)86513-4

M. Denison, A. Pandini, S. Nagy, E. Baldwin, and L. Bonati, Ligand binding and activation of the Ah receptor, Chemico-Biological Interactions, vol.141, issue.1-2, pp.3-24, 2002.
DOI : 10.1016/S0009-2797(02)00063-7

M. Denissenko, A. Pao, M. Tang, and G. Pfeifer, Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53, Science, vol.274, issue.5286, pp.430-432, 1996.
DOI : 10.1126/science.274.5286.430

P. Devanesan, N. Ramakrishna, R. Todorovic, E. Rogan, E. Cavalieri et al., Identification and quantitation of benzo[a]pyrene-DNA adducts formed by rat liver microsomes in vitro, Chemical Research in Toxicology, vol.5, issue.2, pp.302-311, 1992.
DOI : 10.1021/tx00026a024

B. Doonaert and A. Pichard, Hydrocarbures Aromatiques Polycycliques (HAPs) Rapport final, p.2003

D. Four, V. Janssen, C. Brits, E. Van-larebeke, and N. , Genotoxic and mutagenic activity of environmental air samples from different rural, urban and industrial sites in Flanders, Belgium, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.588, issue.2, pp.106-123, 2005.
DOI : 10.1016/j.mrgentox.2005.09.007

J. Durant, W. Busby, J. Lafleur, A. Penman, B. Crespi et al., Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols, Mutation Research/Genetic Toxicology, vol.371, issue.3-4, pp.3-4123, 1996.
DOI : 10.1016/S0165-1218(96)90103-2

B. Ebert, A. Seidel, and A. Lampen, Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. Toxicology letters, pp.140-51, 2005.

T. Fatur, T. Lah, and M. Filipic, Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.529, issue.1-2, pp.109-125, 2003.
DOI : 10.1016/S0027-5107(03)00112-X

K. Forster, R. Preuss, B. Rossbach, T. Bruning, J. Angerer et al., 3-Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries, Occupational and Environmental Medicine, vol.65, issue.4, 2008.
DOI : 10.1136/oem.2006.030809

K. Foster, C. Oster, M. Mayer, M. Avery, and K. Audus, Characterization of the A549 Cell Line as a Type II Pulmonary Epithelial Cell Model for Drug Metabolism, Experimental Cell Research, vol.243, issue.2, pp.359-66, 1998.
DOI : 10.1006/excr.1998.4172

R. Franco, O. Schoneveld, A. Georgakilas, and M. Panayiotidis, Oxidative stress, DNA methylation and carcinogenesis, Cancer Letters, vol.266, issue.1, pp.6-11, 2008.
DOI : 10.1016/j.canlet.2008.02.026

S. Frelon, T. Douki, J. Ravanat, C. Tornabene, and J. Cadet, High-Performance Liquid Chromatography???Tandem Mass Spectrometry Measurement of Radiation-Induced Base Damage to Isolated and Cellular DNA, Chemical Research in Toxicology, vol.13, issue.10, pp.1002-1012, 2000.
DOI : 10.1021/tx000085h

A. Gabelova, Z. Valovicova, E. Horvathova, D. Slamenova, B. Binkova et al., Genotoxicity of environmental air pollution in three European cities: Prague, Ko??ice and Sofia, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.563, issue.1, pp.49-59, 2004.
DOI : 10.1016/j.mrgentox.2004.05.014

R. Gaertner and G. Theriault, Risk of bladder cancer in foundry workers: a meta-analysis. Occupational and environmental medicine, pp.655-63, 2002.

N. Gamage, A. Barnett, N. Hempel, R. Duggleby, K. Windmill et al., Human Sulfotransferases and Their Role in Chemical Metabolism, Toxicological Sciences, vol.90, issue.1, 2006.
DOI : 10.1093/toxsci/kfj061

G. Ginsberg and T. Atherholt, DNA adduct formation in mouse tissues in relation to serum levels of benzo(a)pyrene-diol-epoxide after injection of benzo(a)pyrene or the diolepoxide, Cancer Res Feb, vol.1550, issue.4, pp.1189-94, 1990.

R. Godschalk, E. Moonen, P. Schilderman, W. Broekmans, J. Kleinjans et al., Exposure-route-dependent DNA adduct formation by polycyclic aromatic hydrocarbons, Carcinogenesis, vol.21, issue.1, pp.87-92, 2000.
DOI : 10.1093/carcin/21.1.67

D. Goodhead, The Initial Physical Damage Produced by Ionizing Radiations, International Journal of Radiation Biology, vol.35, issue.5, pp.623-657, 1989.
DOI : 10.1080/09553008914551841

M. Goriaux, B. Jourdain, B. Temime, J. Besombes, N. Marchand et al., Field comparison of particulate PAH measurements using a low-flow denuder device and conventional sampling systems. Environmental science & technology, pp.6398-404, 2006.
URL : https://hal.archives-ouvertes.fr/ineris-00963026

M. Grant, S. Duthie, A. Gray, and M. Burke, Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line, Biochemical Pharmacology, vol.37, issue.21, pp.4111-4117, 1988.
DOI : 10.1016/0006-2952(88)90103-7

G. Grimmer, H. Brune, G. Dettbarn, J. Jacob, J. Misfeld et al., Relevance of polycyclic aromatic hydrocarbons as environmental carcinogens, Fresenius' Journal of Analytical Chemistry, vol.43, issue.10, pp.792-797, 1991.
DOI : 10.1007/BF00321747

E. Gyorffy, L. Anna, Z. Gyori, J. Segesdi, J. Minarovits et al., DNA adducts in tumour, normal peripheral lung and bronchus, and peripheral blood lymphocytes from smoking and non-smoking lung cancer patients: correlations between tissues and detection by 32P-postlabelling and immunoassay, Carcinogenesis, vol.25, issue.7, pp.1201-1210, 2004.
DOI : 10.1093/carcin/bgh131

L. Hagmar, S. Bonassi, U. Stromberg, A. Brogger, L. Knudsen et al., Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH), Cancer Res, vol.58, issue.18, pp.4117-4138, 1998.

W. Hansen and M. Kelley, Review of mammalian DNA repair and translational implications, J Pharmacol Exp Ther, vol.295, issue.1, pp.1-9, 2000.

J. Harrigan, B. Mcgarrigle, T. Sutter, and J. Olson, Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene, Toxicology in Vitro, vol.20, issue.4, pp.426-464, 20062006-06.
DOI : 10.1016/j.tiv.2005.08.015

J. Harrigan, C. Vezina, B. Mcgarrigle, N. Ersing, H. Box et al., DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene, Toxicological Sciences, vol.77, issue.2, pp.307-321, 2004.
DOI : 10.1093/toxsci/kfh030

A. Hartmann, A. Elhajouji, E. Kiskinis, F. Poetter, H. Martus et al., Use of the alkaline comet assay for industrial genotoxicity screening -comparative investigation with the micronucleus test, Food Chem Toxicol, issue.8, pp.39843-58, 2001.

C. Hassett, L. Aicher, J. Sidhu, and C. Omiecinski, Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Human molecular genetics, pp.421-429, 1994.

S. Hayashi, J. Watanabe, and K. Kawajiri, High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu-class Glutathione S-Transferase Genes, Japanese Journal of Cancer Research, vol.1, issue.32, pp.866-70, 1992.
DOI : 10.1111/j.1349-7006.1992.tb01992.x

J. He, W. Chen, L. Jin, and H. Jin, Comparative evaluation of the in vitro micronucleus test and the comet assay for the detection of genotoxic effects of X-ray radiation, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.469, issue.2, pp.223-254, 2000.
DOI : 10.1016/S1383-5718(00)00077-2

A. Hirvonen, Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer Environmental health perspectives 1999 Feb, pp.37-47

J. Holme, M. Gorria, V. Arlt, S. Ovrebo, A. Solhaug et al., Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells, Chemico-Biological Interactions, vol.167, issue.1, pp.41-55, 2007.
DOI : 10.1016/j.cbi.2007.01.008
URL : https://hal.archives-ouvertes.fr/hal-00690306

S. Hussain, P. Amstad, K. Raja, M. Sawyer, L. Hofseth et al., Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung, Cancer Res, issue.17, pp.616350-616355, 2001.

J. Jager and M. Rakovic, Suplphur-dioxide-induced qualitative changes in polycyclic aromatic hydrocarbons adsorbed on solid carriers, Journal of hygiene, epidemiology, microbiology, and immunology, vol.18, issue.2, pp.137-180, 1974.

F. Jongeneelen, Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons. The Annals of occupational hygiene, pp.3-13, 2001.

B. Ketterer, J. Harris, G. Talaska, D. Meyer, S. Pemble et al., The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer, Environmental Health Perspectives, vol.98, pp.87-94, 1992.
DOI : 10.1289/ehp.929887

N. Khalili, P. Scheff, and T. Holsen, PAH source fingerprints for coke ovens, diesel and, gasoline engines, highway tunnels, and wood combustion emissions, Atmospheric Environment, vol.29, issue.4, pp.533-575, 1995.
DOI : 10.1016/1352-2310(94)00275-P

J. Kim, K. Stransbury, N. Walker, M. Trush, P. Strickland et al., Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1, Carcinogenesis, vol.19, issue.10, pp.1847-53, 1998.
DOI : 10.1093/carcin/19.10.1847

J. Kim, J. Chung, J. Park, S. Lee, Y. Kim et al., Benzo[a]pyrene Induces Apoptosis in RL95-2 Human Endometrial Cancer Cells by Cytochrome P450 1A1 Activation, Endocrinology, vol.148, issue.10, pp.5112-5134, 2007.
DOI : 10.1210/en.2007-0096

C. King, G. Rios, M. Green, and T. Tephly, UDP-Glucuronosyltransferases, Current Drug Metabolism, vol.1, issue.2, pp.143-61, 2000.
DOI : 10.2174/1389200003339171

T. Kuljukka-rabb, K. Peltonen, S. Isotalo, S. Mikkonen, L. Rantanen et al., Time- and dose-dependent DNA binding of PAHs derived from diesel particle extracts, benzo[a]pyrene and 5-methylchrysene in a human mammary carcinoma cell line (MCF-7), Mutagenesis, vol.16, issue.4, pp.353-361, 2001.
DOI : 10.1093/mutage/16.4.353

T. Kuljukka, R. Vaaranrinta, T. Veidebaum, M. Sorsa, and K. Peltonen, Exposure to PAH compounds among cokery workers in the oil shale industry, Environmental Health Perspectives, vol.104, issue.Suppl 3, pp.539-580, 1996.
DOI : 10.1289/ehp.96104s3539

R. Larsson and P. Cerutti, Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants, Cancer Res, vol.49, issue.20, pp.5627-5659, 1989.

M. Lazarova and D. Slamenova, Genotoxic effects of a complex mixture adsorbed onto ambient air particles on human cells in vitro; the effects of Vitamins E and C, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.557, issue.2, pp.167-75, 2004.
DOI : 10.1016/j.mrgentox.2003.10.011

L. Page, F. Margot, A. Grollman, A. Sarasin, A. Gentil et al., sequence in mammalian cells, Carcinogenesis, vol.16, issue.11, 1995.
DOI : 10.1093/carcin/16.11.2779

M. Lee, M. Novotny, and K. Bartle, Gas chromatography/mass spectrometric and nuclear magnetic resonance determination of polynuclear aromatic hydrocarbons in airborne particulates, Analytical Chemistry, vol.48, issue.11, pp.1566-72, 1976.
DOI : 10.1021/ac50005a037

W. Lei, R. Yu, S. Mandlekar, and A. Kong, Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene, Cancer Res, vol.58, issue.10, pp.2102-2108, 1998.

E. Leoz-garziandia, Programme pilote national de surveillance des Hydrocarbures Aromatiques Polycycliques (HAP): Institut National de l'environnement industriel et des risques (INERIS) Décembre, 2003.

J. Lewtas and J. Gallagher, Complex mixtures of urban air pollutants: identification and comparative assessment of mutagenic and tumorigenic chemicals and emission sources, IARC scientific publications, issue.104, pp.252-60, 1990.

M. Lodovici, M. Venturini, E. Marini, D. Grechi, and P. Dolara, Polycyclic aromatic hydrocarbons air levels in Florence, Italy, and their correlation with other air pollutants, Chemosphere, vol.50, issue.3, pp.377-82, 2003.
DOI : 10.1016/S0045-6535(02)00404-6

S. Lundstedt, P. White, C. Lemieux, K. Lynes, I. Lambert et al., Sources, Fate, and Toxic Hazards of Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs) at PAH- contaminated Sites, AMBIO: A Journal of the Human Environment, vol.36, issue.6, pp.475-85, 2007.
DOI : 10.1579/0044-7447(2007)36[475:SFATHO]2.0.CO;2

M. Machala, J. Vondracek, L. Blaha, M. Ciganek, and J. Neca, Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.497, issue.1-2, pp.49-62, 2001.
DOI : 10.1016/S1383-5718(01)00240-6

B. Mahadevan, C. Keshava, T. Musafia-jeknic, A. Pecaj, A. Weston et al., Altered Gene Expression Patterns in MCF-7 Cells Induced by the Urban Dust Particulate Complex Mixture Standard Reference Material 1649a, Cancer Research, vol.65, issue.4, pp.1251-1259, 2005.
DOI : 10.1158/0008-5472.CAN-04-2357

B. Mahadevan, C. Marston, W. Dashwood, Y. Li, C. Pereira et al., Effect of a Standardized Complex Mixture Derived from Coal Tar on the Metabolic Activation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Human Cells in Culture, Chemical Research in Toxicology, vol.18, issue.2, pp.224-255, 2005.
DOI : 10.1021/tx0497604

B. Mahadevan, C. Marston, A. Luch, W. Dashwood, E. Brooks et al., Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar, International Journal of Cancer, vol.15, issue.6, pp.1161-1169, 2007.
DOI : 10.1002/ijc.22466

A. Marchand, R. Barouki, and M. Garlatti, Regulation of NAD(P)H:Quinone Oxidoreductase 1 Gene Expression by CYP1A1 Activity, Molecular Pharmacology, vol.65, issue.4, pp.1029-1066, 2004.
DOI : 10.1124/mol.65.4.1029

N. Marchand, J. Besombes, P. Masclet, and J. Jaffrezo, Atmospheric Polycyclic Aromatic Hydrocarbons (PAHs) in Two French Alpine Valleys, Environmental Chemistry2005, pp.409-426
DOI : 10.1007/3-540-26531-7_37
URL : https://hal.archives-ouvertes.fr/insu-00502200

N. Marchand, J. Besombes, N. Chevron, P. Masclet, G. Aymoz et al., Polycyclic aromatic hydrocarbons (PAHs) in the atmospheres of two French alpine valleys: sources and temporal patterns, Atmospheric Chemistry and Physics, vol.4, issue.5, pp.1167-81, 2004.
DOI : 10.5194/acp-4-1167-2004
URL : https://hal.archives-ouvertes.fr/hal-00328366

C. Marie, Recherche de nouveaux biomarqueurs d'exposition aux hydrocarbures aromatiques polycycliques à travers l'étude des lésions de l'ADN chez l'homme, 2007.

C. Marie, A. Maitre, T. Douki, M. Gateau, A. Tarantini et al., Influence of the metabolic properties of human cells on the kinetic of formation of the major benzo[a]pyrene DNA adducts, Journal of Applied Toxicology, vol.13, issue.5739, pp.579-90, 2008.
DOI : 10.1002/jat.1306

C. Marie, J. Ravanat, C. Badouard, M. Marques, F. Balducci et al., Urinary levels of oxidative DNA and RNA damage among workers exposed to polycyclic aromatic hydrocarbons in silicon production: Comparison with 1-hydroxypyrene, Environmental and Molecular Mutagenesis, vol.76, issue.2, pp.88-95, 2009.
DOI : 10.1002/em.20439

C. Marston, C. Pereira, J. Ferguson, K. Fisher, O. Hedstrom et al., Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis, Carcinogenesis, vol.22, issue.7, pp.1077-86, 2001.
DOI : 10.1093/carcin/22.7.1077

P. Masclet, K. Nikolau, and G. Mouvier, Identification Des Sources D???Hydrocarbures Aromatiques Polycycliques Particulaires Dans L???Atmosphere Urbaine, Physico- Chemical behavior of atmospheric pollutant Third European Symposium, 1984.
DOI : 10.1007/978-94-009-6505-8_64

A. Mastral, J. Lopez, M. Callen, T. Garcia, R. Murillo et al., Spatial and temporal PAH concentrations in Zaragoza, Spain, The Science of The Total Environment, vol.307, issue.1-3, pp.1-3111, 2003.
DOI : 10.1016/S0048-9697(02)00460-6

G. Mastrangelo, E. Fadda, and V. Marzia, Polycyclic aromatic hydrocarbons and cancer in man, Environmental Health Perspectives, vol.104, issue.11, pp.1166-70, 1996.
DOI : 10.1289/ehp.961041166

J. Mates, J. Segura, F. Alonso, and J. Marquez, Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis, Archives of Toxicology, vol.350, issue.5, pp.273-99, 2008.
DOI : 10.1007/s00204-008-0304-z

V. Melendez-colon, A. Luch, A. Seidel, and W. Baird, Formation of Stable DNA Adducts and Apurinic Sites upon Metabolic Activation of Bay and Fjord Region Polycyclic Aromatic Hydrocarbons in Human Cell Cultures, Chemical Research in Toxicology, vol.13, issue.1, pp.10-17, 2000.
DOI : 10.1021/tx9802724

T. Mensing, B. Marczynski, B. Engelhardt, M. Wilhelm, R. Preuss et al., DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons, International Journal of Hygiene and Environmental Health, vol.208, issue.3, pp.173-181, 2005.
DOI : 10.1016/j.ijheh.2005.01.023

M. Merchant, X. Wang, C. Kamps, R. Rosengren, V. Morrison et al., Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. Archives of biochemistry and biophysics, 1992.

W. Miao, L. Hu, P. Scrivens, and G. Batist, Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway: DIRECT CROSS-TALK BETWEEN PHASE I AND II DRUG-METABOLIZING ENZYMES, Journal of Biological Chemistry, vol.280, issue.21, pp.20340-20348, 2005.
DOI : 10.1074/jbc.M412081200

K. Miller and K. Ramos, Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons. Drug metabolism reviews, 2001.

D. Moir, A. Viau, I. Chu, J. Withey, and E. Mcmullen, The pharmacokinetics of benzo(a)pyrene in the rat, Toxicology Letters, vol.88, issue.7, pp.507-537, 1998.
DOI : 10.1016/S0378-4274(96)80319-5

R. Moody, B. Nadeau, and I. Chu, In vivo and in vitro dermal absorption of benzo[a]pyrene in rat, guinea pig, human and tissue-cultured skin, Journal of Dermatological Science, vol.9, issue.1, pp.48-58, 1995.
DOI : 10.1016/0923-1811(94)00356-J

Y. Morel, N. Mermod, and R. Barouki, and NFI, Molecular and Cellular Biology, vol.19, issue.10, pp.6825-6857, 1999.
DOI : 10.1128/MCB.19.10.6825

M. Moriya, Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells., Proceedings of the National Academy of Sciences, vol.90, issue.3, pp.1122-1128, 1993.
DOI : 10.1073/pnas.90.3.1122

T. Musafia-jeknic, B. Mahadevan, C. Pereira, and W. Baird, Long-Term Effects of a Standardized Complex Mixture of Urban Dust Particulate on the Metabolic Activation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Human Cells in Culture, Toxicological Sciences, vol.88, issue.2, 2005.
DOI : 10.1093/toxsci/kfi329

T. Nguyen, P. Nioi, and C. Pickett, The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress, Journal of Biological Chemistry, vol.284, issue.20, pp.13291-13296, 2009.
DOI : 10.1074/jbc.R900010200

K. Nikolaou, P. Masclet, and G. Mouvier, Sources and chemical reactivity of polynuclear aromatic hydrocarbons in the atmosphere ? a critical review Science of the total environment, pp.103-135, 1984.

I. Nisbet and P. Lagoy, Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs), Regulatory Toxicology and Pharmacology, vol.16, issue.3, pp.290-300, 1992.
DOI : 10.1016/0273-2300(92)90009-X

F. Oesch, Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds. Xenobiotica; the fate of foreign compounds in biological systems, 1973.

M. Osborne, R. Harvey, and P. Brookes, The reaction of trans-7,8-dihydroxy-anti-9(a)pyrene with DNA involves attack at the N7-position of guanine moieties, Chem Biol Interact, vol.108920, issue.71, pp.10-123, 1978.

A. Papageorgopoulou, E. Manoli, E. Touloumi, and C. Samara, Polycyclic aromatic hydrocarbons in the ambient air of Greek towns in relation to other atmospheric pollutants, Chemosphere, vol.39, issue.13, pp.2183-99, 1999.
DOI : 10.1016/S0045-6535(99)00143-5

R. Pastorelli, M. Guanci, A. Cerri, E. Negri, L. Vecchia et al., Impact of inherited polymorphisms in glutathione S-transferase M1, microsomal epoxide hydrolase, cytochrome P450 enzymes on DNA, and blood protein adducts of benzo(a)pyrene-diolepoxide, Cancer Epidemiol Biomarkers Prev, vol.7, issue.8, pp.703-712, 1998.

W. Patton, U. Chakravarthy, R. Davies, and D. Archer, Comet assay of UV-induced DNA damage in retinal pigment epithelial cells, Invest Ophthalmol Vis Sci, 1999.

T. Penning, M. Burczynski, C. Hung, K. Mccoull, N. Palackal et al., -Quinones, Chemical Research in Toxicology, vol.12, issue.1, 1999.
DOI : 10.1021/tx980143n
URL : https://hal.archives-ouvertes.fr/hal-00889346

T. Penning, S. Ohnishi, T. Ohnishi, and R. Harvey, -Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase, Chemical Research in Toxicology, vol.9, issue.1, pp.84-92, 1996.
DOI : 10.1021/tx950055s
URL : https://hal.archives-ouvertes.fr/hal-00889346

P. Guengerich, F. Chun, Y. Kim, D. Gillam, E. Shimada et al., Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.523, issue.524, pp.173-82, 2003.
DOI : 10.1016/S0027-5107(02)00333-0

R. Pierce and M. Katz, Chromatographic isolation and spectral analysis of polycyclic quinones. Application to air pollution analysis, Environmental Science & Technology, vol.10, issue.1, pp.45-51, 1976.
DOI : 10.1021/es60112a007

J. Pitts, J. Lokensgard, D. Ripley, P. , K. Vanc et al., "Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide, Science, vol.210, issue.4476, pp.1347-1356, 1980.
DOI : 10.1126/science.210.4476.1347

J. Pitts, J. Van-cauwenberghe, K. Grosjean, D. Schmid, J. Fitz et al., Atmospheric reactions of polycyclic aromatic hydrocarbons: facile formation of mutagenic nitro derivatives, Science, vol.202, issue.4367, pp.515-524, 1978.
DOI : 10.1126/science.705341

J. Pouget, T. Douki, M. Richard, and J. Cadet, DNA Damage Induced in Cells by ?? and UVA Radiation As Measured by HPLC/GC???MS and HPLC???EC and Comet Assay, Chemical Research in Toxicology, vol.13, issue.7, pp.541-550, 2000.
DOI : 10.1021/tx000020e

K. Prevedouros, E. Brorstrom-lunden, C. Jh, K. Jones, R. Lee et al., Seasonal and long-term trends in atmospheric PAH concentrations: evidence and implications, Environmental Pollution, vol.128, issue.1-2, pp.17-27, 2004.
DOI : 10.1016/j.envpol.2003.08.032

H. Prochaska, D. Long, M. Talalay, and P. , On the mechanisms of induction of cancer-protective enzymes: a unifying proposal., Proceedings of the National Academy of Sciences, vol.82, issue.23, pp.8232-8238, 1985.
DOI : 10.1073/pnas.82.23.8232

R. Prough, M. Burke, and R. Mayer, [39] Direct fluorometric methods for measuring mexed-function oxidase activity, Methods in enzymology, vol.52, pp.372-379, 1978.
DOI : 10.1016/S0076-6879(78)52041-7

D. Pushparajah, M. Umachandran, T. Nazir, K. Plant, N. Plant et al., Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size, Toxicology in Vitro, vol.22, issue.1, pp.128-173, 2008.
DOI : 10.1016/j.tiv.2007.08.014

S. Qu and N. Stacey, ]pyrene, Carcinogenesis, vol.17, issue.1, 1996.
DOI : 10.1093/carcin/17.1.53

V. Radjendirane and A. Jaiswal, Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:Quinone oxidoreductase 1 gene expression, Biochemical Pharmacology, vol.58, issue.10, pp.1649-55, 1999.
DOI : 10.1016/S0006-2952(99)00245-2

K. Randerath, M. Reddy, and R. Gupta, 32P-labeling test for DNA damage., Proceedings of the National Academy of Sciences, vol.78, issue.10, pp.6126-6135, 1981.
DOI : 10.1073/pnas.78.10.6126

W. Rogge, L. Hildemann, M. Mazurek, G. Cass, and B. Simoneit, Sources of fine organic aerosol. 2. Noncatalyst and catalyst-equipped automobiles and heavy-duty diesel trucks, Environmental Science & Technology, vol.27, issue.4, pp.636-51, 1993.
DOI : 10.1021/es00041a007

J. Ross, G. Nelson, A. Kligerman, G. Erexson, M. Bryant et al., Formation and persistence of novel benzo(a)pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA, Cancer Res, vol.50, issue.16, pp.5088-94, 1990.

C. Rossi, P. Poli, A. Buschini, F. Cassoni, S. Cattani et al., Comparative investigations among meteorological conditions, air chemical-physical pollutants and airborne particulate mutagenicity: A long-term study (1990???1994) from a northern Italian town, Chemosphere, vol.30, issue.10, pp.1829-1874, 1995.
DOI : 10.1016/0045-6535(95)00065-G

S. Safe, Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds, Teratogenesis, carcinogenesis, and mutagenesis, vol.17, pp.4-5285, 1997.

S. Salama, C. Sierra-torres, H. Oh, F. Hamada, and W. Au, Variant metabolizing gene alleles determine the genotoxicity of benzo[a]pyrene, Environmental and Molecular Mutagenesis, vol.5, issue.113, pp.17-26, 2001.
DOI : 10.1002/1098-2280(2001)37:1<17::AID-EM1002>3.0.CO;2-F

V. Salas and S. Burchiel, Apoptosis in Daudi Human B Cells in Response to Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol, Toxicology and Applied Pharmacology, vol.151, issue.2, pp.367-76, 1998.
DOI : 10.1006/taap.1998.8455

S. Saldivar, Y. Wang, H. Zhao, L. Shao, J. Lin et al., An association between a NQO1 genetic polymorphism and risk of lung cancer, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.582, issue.1-2, pp.71-79, 2005.
DOI : 10.1016/j.mrgentox.2004.12.010

J. Sayer, A. Chadha, S. Agarwal, H. Yeh, H. Yagi et al., Covalent nucleoside adducts of benzo[a]pyrene 7,8-diol 9,10-epoxides: structural reinvestigation and characterization of a novel adenosine adduct on the ribose moiety, The Journal of Organic Chemistry, vol.56, issue.1, pp.20-29, 1991.
DOI : 10.1021/jo00001a007

K. Schneider, M. Roller, F. Kalberlah, and U. Schuhmacher-wolz, Cancer risk assessment for oral exposure to PAH mixtures, Journal of Applied Toxicology, vol.106, issue.1, pp.73-83, 2002.
DOI : 10.1002/jat.828

O. Sevastyanova, B. Binkova, J. Topinka, R. Sram, I. Kalina et al., In vitro genotoxicity of PAH mixtures and organic extract from urban air particles, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.620, issue.1-2, pp.123-157, 2007.
DOI : 10.1016/j.mrfmmm.2007.03.002

P. Shah, V. Jogani, T. Bagchi, and A. Misra, Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnology progress, pp.186-98, 2006.

D. Sheehan, G. Meade, V. Foley, and C. Dowd, Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily, Biochemical Journal, vol.360, issue.1, pp.1-16, 2001.
DOI : 10.1042/bj3600001

Y. Shen, A. Troxel, S. Vedantam, T. Penning, and J. Field, Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection, Chem Res Toxicol, 2006.

H. Sheu, W. Lee, S. Lin, G. Fang, H. Chang et al., Particle-bound PAH content in ambient air, Environmental Pollution, vol.96, issue.3, pp.369-82, 1997.
DOI : 10.1016/S0269-7491(97)00044-4

T. Shimada, Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons, Drug Metabolism and Pharmacokinetics, vol.21, issue.4, 2006.
DOI : 10.2133/dmpk.21.257

T. Shimada, K. El-bayoumy, P. Upadhyaya, T. Sutter, F. Guengerich et al., Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds, Cancer Res, vol.57, issue.21, pp.4757-64, 1997.

T. Shimada and Y. Fujii-kuriyama, Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1, Cancer Science, vol.12, issue.1, pp.1-6, 2004.
DOI : 10.1126/science.275.5297.218

T. Shimada and F. Guengerich, Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons, Chemical Research in Toxicology, vol.19, issue.2, pp.288-94, 2006.
DOI : 10.1021/tx050291v

T. Shimada, C. Hayes, H. Yamazaki, S. Amin, S. Hecht et al., Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1, Cancer Res, vol.56, issue.13, pp.2979-84, 1996.

T. Shimada, K. Inoue, Y. Suzuki, T. Kawai, E. Azuma et al., Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice, Carcinogenesis, vol.23, issue.7, pp.1199-207, 2002.
DOI : 10.1093/carcin/23.7.1199

T. Shimada, M. Martin, P. Schwartz, D. Marnett, L. Guengerich et al., Roles of Individual Human Cytochrome P-450 Enzymes in the Bioactivation of Benzo(a)pyrene, 7,8- Dihydroxy-7,8-dihydrobenzo(a)pyrene, and Other Dihydrodiol Derivatives of Polycyclic Aromatic Hydrocarbons, Cancer Research, vol.49, pp.6304-6316, 1989.

T. Shimada, N. Murayama, K. Okada, Y. Funae, H. Yamazaki et al., Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors, Chemical Research in Toxicology, vol.20, issue.3, pp.489-96, 2007.
DOI : 10.1021/tx600299p

T. Shimada, Y. Oda, E. Gillam, F. Guengerich, and K. Inoue, Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug metabolism and disposition: the biological fate of chemicals, 2001.

T. Shimada, A. Sugie, M. Shindo, T. Nakajima, E. Azuma et al., Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene, Toxicology and Applied Pharmacology, vol.187, issue.1, pp.1-10, 2003.
DOI : 10.1016/S0041-008X(02)00035-2

T. Shimada, H. Yamazaki, M. Foroozesh, N. Hopkins, W. Alworth et al., Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1, Chemical Research in Toxicology, vol.11, issue.9, pp.1048-56, 1998.
DOI : 10.1021/tx980090+

M. Simcik, S. Eisenreich, and P. Lioy, Source apportionment and source/sink relationships of PAHs in the coastal atmosphere of Chicago and Lake Michigan, Atmospheric Environment, vol.33, issue.30, pp.5071-5080, 1999.
DOI : 10.1016/S1352-2310(99)00233-2

N. Singh, M. Coy, M. Tice, R. Schneider, and E. , A simple technique for quantitation of low levels of DNA damage in individual cells, Experimental Cell Research, vol.175, issue.1, pp.184-91, 1988.
DOI : 10.1016/0014-4827(88)90265-0

R. Singh, R. Sram, B. Binkova, I. Kalina, T. Popov et al., The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air pollution in humans, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.620, issue.1-2, pp.83-92, 2007.
DOI : 10.1016/j.mrfmmm.2007.02.025

M. Skarek, J. Janosek, P. Cupr, J. Kohoutek, A. Novotna-rychetska et al., Evaluation of genotoxic and non-genotoxic effects of organic air pollution using in vitro bioassays, Environment International, vol.33, issue.7, pp.859-66, 2007.
DOI : 10.1016/j.envint.2007.04.001

K. Skupinska, I. Misiewicz, and T. Kasprzycka-guttman, A comparison of the concentration???effect relationships of PAHs on CYP1A induction in HepG2 and Mcf7 cells, Archives of Toxicology, vol.12, issue.3, 2006.
DOI : 10.1007/s00204-006-0140-y

K. Skupinska, I. Misiewicz, and T. Kasprzycka-guttman, A comparison of the concentration???effect relationships of PAHs on CYP1A induction in HepG2 and Mcf7 cells, Archives of Toxicology, vol.12, issue.3, pp.183-200, 2007.
DOI : 10.1007/s00204-006-0140-y

D. Smith and R. Harrison, Concentrations, trends and vehicle source profile of polynuclear aromatic hydrocarbons in the U.K. atmosphere, Atmospheric Environment, vol.30, issue.14, pp.2513-2538, 1996.
DOI : 10.1016/1352-2310(95)00474-2

T. Smithgall, R. Harvey, and T. Penning, Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism, J Biol Chem Feb, vol.5263, issue.4, pp.1814-1834, 1988.

A. Solhaug, S. Ovrebo, S. Mollerup, M. Lag, P. Schwarze et al., Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites, Chemico-Biological Interactions, vol.151, issue.2, pp.101-120, 2005.
DOI : 10.1016/j.cbi.2004.12.002

A. Solhaug, M. Refsnes, M. Lag, P. Schwarze, T. Husoy et al., Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells, Carcinogenesis, vol.25, issue.5, pp.809-828, 2004.
DOI : 10.1093/carcin/bgh069

D. Spink, S. Wu, B. Spink, M. Hussain, D. Vakharia et al., Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: Roles of PAH interactions and PAH metabolites, Toxicology and Applied Pharmacology, vol.226, issue.3, pp.213-237, 2008.
DOI : 10.1016/j.taap.2007.08.024

S. Srivastava, X. Hu, H. Xia, S. Awasthi, S. Amin et al., Metabolic fate of glutathione conjugate of benzo[a]pyrene-(7R,8S)-diol (9S,10R)-epoxide in human liver. Archives of biochemistry and biophysics, pp.340-344, 1999.

Y. Staal, D. Hebels, M. Van-herwijnen, R. Gottschalk, F. Van-schooten et al., Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation, Carcinogenesis, vol.28, issue.12, pp.2632-2672, 2007.
DOI : 10.1093/carcin/bgm182

K. Sterling, A. Raha, and E. Bresnick, Induction of CYP1A1 Gene Expression in Mouse Hepatoma Cells by Benzo(e)Pyrene, a Ligand of the 4S Polycyclic Hydrocarbon-Binding Protein, Toxicology and Applied Pharmacology, vol.128, issue.1, pp.18-24, 1994.
DOI : 10.1006/taap.1994.1175

S. Stohs and D. Bagchi, Oxidative mechanisms in the toxicity of metal ions. Free radical biology & medicine 1995 Feb, pp.321-357

P. Strickland and D. Kang, Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter, Toxicology Letters, vol.108, issue.2-3, pp.191-200, 1999.
DOI : 10.1016/S0378-4274(99)00089-2

J. Swenberg, D. La, N. Scheller, and K. Wu, Dose-response relationships for carcinogens, Toxicology Letters, vol.82, issue.83, pp.82-83751, 1995.
DOI : 10.1016/0378-4274(95)03593-1

A. Szczeklik, J. Szczeklik, Z. Galuszka, J. Musial, E. Kolarzyk et al., Humoral immunosuppression in men exposed to polycyclic aromatic hydrocarbons and related carcinogens in polluted environments, Environmental Health Perspectives, vol.102, issue.3, 1994.
DOI : 10.1289/ehp.94102302

B. Tebbens, J. Thomas, and M. Mukai, Fate of Arenes Incorporated with Airborne Soot, American Industrial Hygiene Association Journal, vol.10, issue.5, pp.415-437, 1966.
DOI : 10.1021/ac60212a053

T. Thorslund and D. Farrer, Development of relative potency estimated for PAHs and hydrocarbon combustion product fractions compared to benzo(a)pyrene and their use in carcinogenic risk assessments

R. Tice, P. Andrews, O. Hirai, and N. Singh, The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Individual Cells, Adv Exp Med Biol, vol.283, pp.157-64, 1991.
DOI : 10.1007/978-1-4684-5877-0_17

M. Till, D. Riebniger, H. Schmitz, and D. Schrenk, Potency of various polycyclic aromatic hydrocarbons as inducers of CYP1A1 in rat hepatocyte cultures, Chemico-Biological Interactions, vol.117, issue.2, pp.135-50, 1999.
DOI : 10.1016/S0009-2797(98)00105-7

H. Tokiwa, N. Sera, A. Nakashima, K. Nakashima, Y. Nakanishi et al., Mutagenic and carcinogenic significance and the possible induction of lung cancer by nitro aromatic hydrocarbons in particulate pollutants, 1994.

J. Topinka, L. Schwarz, F. Wiebel, M. Cerna, and T. Wolff, Genotoxicity of urban air pollutants in the Czech Republic, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.469, issue.1, pp.83-93, 2000.
DOI : 10.1016/S1383-5718(00)00061-9

J. Topinka, S. Marvanova, J. Vondracek, O. Sevastyanova, Z. Novakova et al., DNA adducts formation and induction of apoptosis in rat liver epithelial ???stem-like??? cells exposed to carcinogenic polycyclic aromatic hydrocarbons, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.638, issue.1-2, pp.122-154, 2008.
DOI : 10.1016/j.mrfmmm.2007.09.004

P. Tsai, H. Shieh, W. Lee, H. Chen, and T. Shih, Urinary 1-hydroxypyrene as a biomarker of internal dose of polycyclic aromatic hydrocarbons in carbon black workers. The Annals of occupational hygiene, pp.229-264, 2002.

M. Uhl, C. Helma, and S. Knasmuller, Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.468, issue.2, pp.213-238, 2000.
DOI : 10.1016/S1383-5718(00)00051-6

J. Unwin, J. Cocker, E. Scobbie, and H. Chambers, An assessment of occupational exposure to polycyclic aromatic hydrocarbons in the UK. The Annals of occupational hygiene, pp.395-403, 2006.

N. Liu, R. Pause, M. Fasco, E. Bessette, and Q. Zhang, Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures, Toxicol Appl Pharmacol, vol.170, issue.2, pp.93-103, 2001.

D. Vakharia, N. Liu, R. Pause, M. Fasco, E. Bessette et al., Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Drug metabolism and disposition: the biological fate of chemicals, 2001.

I. Valentin-severin, L. Hegarat, L. Lhuguenot, J. , L. Bon et al., Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.536, issue.1-2, pp.79-90, 2003.
DOI : 10.1016/S1383-5718(03)00031-7

A. Van-hoffen, A. Balajee, A. Van-zeeland, and L. Mullenders, Nucleotide excision repair and its interplay with transcription, Toxicology, vol.193, issue.1-2, pp.79-90, 2003.
DOI : 10.1016/j.tox.2003.06.001

J. Van-rooij, E. Van-lieshout, M. Bodelier-bade, and F. Jongeneelen, Effect of the reduction of skin contamination on the internal dose of creosote workers exposed to polycyclic aromatic hydrocarbons. Scandinavian journal of work, 1993.

F. Van-schooten, M. Hillebrand, F. Van-leeuwen, N. Van-zandwijk, H. Jansen et al., Polycyclic aromatic hydrocarbon???DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung, Carcinogenesis, vol.13, issue.6, 1992.
DOI : 10.1093/carcin/13.6.987

J. Vanrooij, M. Bodelier-bade, and F. Jongeneelen, Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers., Occupational and Environmental Medicine, vol.50, issue.7, pp.623-655, 1993.
DOI : 10.1136/oem.50.7.623

R. Venugopal and A. Jaiswal, Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes, Oncogene, vol.17, issue.24, pp.3145-56, 1998.
DOI : 10.1038/sj.onc.1202237

C. Waller and J. Mckinney, Three-Dimensional Quantitative Structure-Activity Relationships of Dioxins and Dioxin-like Compounds: Model Validation and Ah Receptor Characterization, Chemical Research in Toxicology, vol.8, issue.6, pp.847-58, 1995.
DOI : 10.1021/tx00048a005

S. Wilkening, F. Stahl, and A. Bader, Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug metabolism and disposition: the biological fate of chemicals, pp.1035-1077, 2003.

A. Wolfe, T. Smith, and T. Meehan, and Ring Imino N-3 Positions, Chemical Research in Toxicology, vol.17, issue.4, pp.476-91, 2004.
DOI : 10.1021/tx0340201

W. Xue and D. Warshawsky, Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review, Toxicology and Applied Pharmacology, vol.206, issue.1, pp.73-93, 2005.
DOI : 10.1016/j.taap.2004.11.006

S. Yang, Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons, Biochemical Pharmacology, vol.37, issue.1, pp.61-70, 1988.
DOI : 10.1016/0006-2952(88)90755-1

Y. Yang, W. Griffiths, T. Midtvedt, J. Sjovall, J. Rafter et al., ]pyrene in Germ-Free Rat Urine by Liquid Chromatography/Electrospray Tandem Mass Spectrometry, Chemical Research in Toxicology, vol.12, issue.12, 1999.
DOI : 10.1021/tx990101e

M. Yunker, R. Macdonald, R. Vingarzan, R. Mitchell, D. Goyette et al., PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition, Organic Geochemistry, vol.33, issue.4, pp.489-515, 2002.
DOI : 10.1016/S0146-6380(02)00002-5

J. Zaleski, S. Bansal, and T. Gessner, Formation of glucuronide, sulphate and glutathione conjugates of benzo[a]pyrene metabolites in hepatocytes isolated from inbred strains of mice, Carcinogenesis, vol.4, issue.11, pp.1359-66, 1983.
DOI : 10.1093/carcin/4.11.1359

A. Tarantini, A. Maitre, E. Lefebvre, M. Marquès, and C. Marie, Jean-Luc Ravanat, and Thierry Douki Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo

A. Tarantini, T. Douki, E. Lefèbvre, C. Marie, and J. Ravanat, Anne Maître Genotoxicity of atmospheric polycyclic aromatic hydrocarbons mixtures: From artificial to realistic mixtures, Toxicol Lett, issue.supp1, pp.189-136, 2009.

C. Marie, A. Maître, T. Douki, M. Gateau, A. Tarantini et al., Influence of the metabolic properties of human cells on the kinetic of formation of the major benzo[a]pyrene DNA adducts, Journal of Applied Toxicology, vol.13, issue.5739, pp.579-90, 2008.
DOI : 10.1002/jat.1306

A. Tarantini, C. Picot, and P. Guiraud, Anne Maître -38ème meeting de l'EEMS (european environmental mutagen society, Cavtat (Croatie) du 21

A. Tarantini, T. Douki, C. Marie, J. Ravanat, C. B. et al., Anne Maître -Journées de la recherche médicale ? université Joseph Fourier, ufr de médecine ? 4 avril 2008 : Evaluation de la génotoxicité des Hydrocarbures Aromatiques Polycycliques en mélange Anne Maître -Journée annuelle du cluster environnement de la Région Rhône-Alpes-13 mai 2008 : Evaluation de la génotoxicité des Hydrocarbures Aromatiques Polycycliques en mélange Adeline Tarantini Anne Maître 2 ème prix du meilleur poster -Colloque francophone international « Les hydrocarbures aromatiques polycycliques, de la recherche à la prévention », 3 et 4 septembre, DNA damage assessed by Comet assay and HPLC-mass spectrometry in human cells exposed to Benzo : évaluation de la génotoxicité des hydrocarbures aromatiques polycycliques (HAPs) en mélange Adeline Tarantini, 2008.

A. Tarantini, T. Douki, C. Marie, J. Ravanat, and E. Lefèbvre, Anne Maître -46ème congrès de la société européenne de toxicologie, Dresde du 13 au 16 septembre 2009 : Genotoxicity of atmospheric polycyclic aromatic hydrocarbons (PAH) : from artificial to realistic mixtures

B. Effet-d-'un-prétraitement-par-du and .. , 25 µM sur la cinétique de formation des cassures et des adduits BPDE-N2-dGuo à l'ADN induits par du B, 91 1

B. Adduits, ADN dans les cellules HepG2 exposées à un même volume d'air prélevé sur différents sites, p.114