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Theses

Détectabilité des matériels d'embolisation vasculaire contrôlée par IRM.

Abstract : Arterial embolization appeared recently as a safe and an effective treatment to stop bleeding or induce devascularisation of a target tissue. Direct visualization of vascular occlusion agents is not always possible. The estimation of their position inside a vascular branch based on the distribution of X-ray contrast agent is partially incorrect. Marked vascular occlusion agents with MRI contrast agent is a good way for MRI follow-up during or after the intervention. In this work, several protocols have been established to demonstrate the feasibility localization of vascular occlusion agents marked with SPIO, in situ, in vitro and in vivo « conditions », at 1,5T and 3T. Studied occlusion agents were tris-acryl microspheres (Embosphere®), and microparticles or microemulsions possibly used as vehicles for drugs : among these, inflatable microspheres (Hepasphere™) aimed to permanent vessel occlusion were marked, alginate microspheres and emulsion droplets for temporary embolization were made by us. Established protocols for microspheres follow-up by MRI involve selection of MR sequences with optimized parameters, coil choice, and determination of contrast agent quantity inside the microparticles in order to make them visible on MRI. A measurement methodology for small variation of signal intensity in images has been proposed. An experimental in vitro model has been designed with the presence of SPIO marked microparticles in an environment simulating a vascular tumor with venous drainage. The fixation of immunoglobulin (IgG1), equivalent to anti-VEGF, to microspheres (Hepaspheres™) has been studied. Finally, mechanical and electrical properties of microemulsions have been explored by ultrasound and impedancemeter.
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Submitted on : Tuesday, February 9, 2010 - 2:54:34 PM
Last modification on : Monday, September 3, 2018 - 1:33:01 PM
Long-term archiving on: : Friday, June 18, 2010 - 7:42:44 PM

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  • HAL Id : tel-00455057, version 1

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H. Jassar. Détectabilité des matériels d'embolisation vasculaire contrôlée par IRM.. Sciences de l'ingénieur [physics]. Université de Technologie de Compiègne, 2009. Français. ⟨tel-00455057⟩

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