L. Sensibilité-ou-la-résistance-À-l, anoïkis dépend du type cellulaire Les études présentées associent des mesures colorimétriques d'activation des caspases 3 et 9, une quantification des cellules Annexine-V positive par cytométrie en flux et une observation

3. Dans-les-cellules-swiss, la caspase 3 est fortement activée, et ceci de façon croissante et significative

A. Algeciras-schimnich, B. Barnhart, and M. Peter, Apoptosis-independent functions of killer caspases, Current Opinion in Cell Biology, vol.14, issue.6, pp.721-727, 2002.
DOI : 10.1016/S0955-0674(02)00384-8

L. Allan, N. Morrice, S. Brady, G. Magee, S. Pathak et al., Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK, Nature Cell Biology, vol.95, issue.7, pp.647-54, 2003.
DOI : 10.1074/jbc.M009953200

A. Aplin, A. Howe, S. Alahari, and R. Juliano, Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins Pharmacol Rev, pp.197-263, 1998.

A. Aplin, A. Howe, and R. Juliano, Cell adhesion molecules, signal transduction and cell growth, Current Opinion in Cell Biology, vol.11, issue.6, pp.737-781, 1999.
DOI : 10.1016/S0955-0674(99)00045-9

W. Arthur and K. Burridge, RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity, Molecular Biology of the Cell, vol.12, issue.9, pp.2711-2731, 2001.
DOI : 10.1091/mbc.12.9.2711

W. Arthur, N. Noren, and K. Burridge, Regulation of Rho family GTPases by cellcell and cell-matrix adhesion, Biol Res, vol.35, pp.239-285, 2002.

A. Banerji, S. Das, and A. Chatterjee, Culture of Human A375 Melanoma Cells in the Presence of Fibronectin Causes Expression of MMP-9 and Activation of MMP-2 in Culture Supernatants, Journal of Environmental Pathology, Toxicology and Oncology, vol.27, issue.2, pp.135-180, 2008.
DOI : 10.1615/JEnvironPatholToxicolOncol.v27.i2.60

L. Barberis, K. Wary, G. Fiucci, F. Liu, E. Hirsch et al., Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK, Journal of Biological Chemistry, vol.275, issue.47, pp.36532-36572, 2000.
DOI : 10.1074/jbc.M002487200

A. Bellacosa, C. Kumar, D. Cristofano, A. Testa, and J. , Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting, Adv Cancer Res, vol.94, pp.29-86, 2005.
DOI : 10.1016/S0065-230X(05)94002-5

A. Bellacosa, J. Testa, R. Moore, and L. L. , A Portrait of AKT Kinases: Human Cancer and Animal Models Depict a Family with Strong Individualities, Cancer Biology & Therapy, vol.3, issue.3, pp.268-75, 2004.
DOI : 10.4161/cbt.3.3.703

A. Bellacosa, J. Testa, S. Staal, and P. Tsichlis, A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region Science, pp.274-281, 1991.

M. Bergman, M. Djaldetti, H. Salman, and H. Bessler, Effect of citrus pectin on malignant cell proliferation Biomedicine & Pharmacotherapy, in press, 2009.

A. Bettaieb, O. Sordet, J. Belon, and E. Solary, [Apoptosis and chemotherapy] Bull Cancer, pp.41-47, 1999.

P. Blume-jensen and T. Hunter, Oncogenic kinase signalling Nature, pp.355-65, 2001.

T. Bogenrieder and M. Herlyn, Cell-surface proteolysis, growth factor activation and intercellular communication in the progression of melanoma, Critical Reviews in Oncology/Hematology, vol.44, issue.1, pp.1-15, 2002.
DOI : 10.1016/S1040-8428(01)00196-2

K. Boisvert-adamo, W. Longmate, E. Abel, and A. Aplin, Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis, Molecular Cancer Research, vol.7, issue.4, pp.549-56, 2009.
DOI : 10.1158/1541-7786.MCR-08-0358

M. Bouaouina, Activation des intégrines et adhérence des leucocytes et des plaquettes, Nouvelles données sur des voies de signalisation communes Hématologie, pp.21-33, 2006.

P. Buongiorno and B. Bapat, Rho GTPases and Cancer, Prog Mol Subcell Biol, vol.40, pp.29-53, 2005.
DOI : 10.1007/3-540-27671-8_2

J. Cai, X. Niu, Y. Chen, Q. Hu, G. Shi et al., Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis Neoplasia, pp.41-51, 2008.

W. Cance, J. Harris, M. Iacocca, E. Roche, X. Yang et al., Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes Clin Cancer Res, pp.2417-2440, 2000.

H. Chang and Y. X. , Proteases for Cell Suicide: Functions and Regulation of Caspases, Microbiology and Molecular Biology Reviews, vol.64, issue.4, pp.821-867, 2000.
DOI : 10.1128/MMBR.64.4.821-846.2000

C. Chen, M. Sheu, T. Chen, Y. Wang, W. Hou et al., Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways, Biochemical Pharmacology, vol.72, issue.8, pp.1001-1010, 2006.
DOI : 10.1016/j.bcp.2006.07.001

L. Chun-yi, L. Cheng-feng, H. Chiung-hui, and W. Yau-huei, Mitochondrial DNA Mutation and Depletion Increase the Susceptibility of Human Cells to, Apoptosis Ann. N.Y. Acad. Sci, pp.133-145, 1011.

P. Chiarugi and E. Giannoni, Anoikis: A necessary death program for anchorage-dependent cells, Biochemical Pharmacology, vol.76, issue.11, pp.1352-64, 2008.
DOI : 10.1016/j.bcp.2008.07.023

J. Cornillon, L. Campos, and D. Guyotat, (FAK), une prot??ine aux fonctions multiples, m??decine/sciences, vol.19, issue.6-7, pp.743-52, 2003.
DOI : 10.1051/medsci/20031967743
URL : http://www.erudit.org/fr/revues/ms/2003-v19-n6-7-ms537/006837ar.pdf

R. Cutler, . Jr, R. Stephens, M. Saracino, and D. Morrison, Autoregulation of the Raf-1 serine/threonine kinase, Proceedings of the National Academy of Sciences, vol.95, issue.16, pp.9214-9223, 1998.
DOI : 10.1073/pnas.95.16.9214

D. Dai, N. Makretsov, E. Campos, C. Huang, Y. Zhou et al., Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival Clin Cancer Res, pp.4409-4423, 2003.

S. Datta, A. Brunet, and M. Greenberg, Cellular survival: a play in three Akts, Genes & Development, vol.13, issue.22, pp.2905-2932, 1999.
DOI : 10.1101/gad.13.22.2905

K. Demali, K. Wennerberg, and K. Burridge, Integrin signaling to the actin cytoskeleton, Current Opinion in Cell Biology, vol.15, issue.5, pp.572-82, 2003.
DOI : 10.1016/S0955-0674(03)00109-1

B. Desoize, D. Gimonet, and J. Jardiller, Cell culture as spheroids: an approach to multicellular resistance, Anticancer Res, vol.18, pp.4147-58, 1998.

B. Desoize, D. Gimonet, and J. Jardillier, Multicellular resistance: another mechanism for multidrug resistance? Bull Cancer, p.785, 1998.

C. Diaz-montero, J. Wygant, and B. Mcintyre, PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation, European Journal of Cancer, vol.42, issue.10, pp.1491-500, 2006.
DOI : 10.1016/j.ejca.2006.03.007

J. Downward, Control of ras activation Cancer Surv, pp.87-100, 1996.

E. Dransart, B. Olofsson, and C. J. , RhoGDIs revisited: novel roles in Rho regulation Traffic, pp.957-66, 2005.

R. Dutta and A. Dutta, Cell-interactive 3D-scaffold; advances and applications, Biotechnology Advances, vol.27, issue.4, pp.334-343, 2009.
DOI : 10.1016/j.biotechadv.2009.02.002

J. Eberle, B. Kurbanov, A. Hossini, U. Trefzer, and L. Fecker, Overcoming apoptosis deficiency of melanoma???Hope for new therapeutic approaches, Drug Resistance Updates, vol.10, issue.6, pp.218-252, 2007.
DOI : 10.1016/j.drup.2007.09.001

J. Engbring, R. Hossain, S. Vanosdol, B. Kaplan-singer, M. Wu et al., The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells Clin Exp Metastasis, pp.241-52, 2008.

N. Faucheux and M. Nagel, Cyclic AMP--dependent aggregation of Swiss 3T3 cells on a cellulose substratum (Cuprophan) and decreased cell membrane Rho A Biomaterials, pp.2295-301, 2002.

W. Fayad, S. Brnjic, D. Berglind, S. Blixt, M. Shoshan et al., Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model, International Journal of Cancer, vol.8, issue.10, 2009.
DOI : 10.1002/ijc.24627

C. Feder-mengus, S. Ghosh, A. Reschner, I. Martin, and G. Spagnoli, New dimensions in tumor immunology: what does 3D culture reveal?, Trends in Molecular Medicine, vol.14, issue.8, pp.333-373, 2008.
DOI : 10.1016/j.molmed.2008.06.001

I. Fidler, Selection of Successive Tumour Lines for Metastasis, Nature New Biology, vol.242, issue.118, pp.148-157, 1973.
DOI : 10.1038/newbio242148a0

S. Fouquet, V. Lugo-martinez, A. Faussat, F. Renaud, P. Cardot et al., Early Loss of E-cadherin from Cell-Cell Contacts Is Involved in the Onset of Anoikis in Enterocytes, Journal of Biological Chemistry, vol.279, issue.41, pp.43061-43070, 2004.
DOI : 10.1074/jbc.M405095200

S. Frisch and F. H. , Disruption of epithelial cell-matrix interactions induces apoptosis, The Journal of Cell Biology, vol.124, issue.4, pp.619-645, 1994.
DOI : 10.1083/jcb.124.4.619

S. Frisch and R. Screaton, Anoikis mechanisms, Current Opinion in Cell Biology, vol.13, issue.5, pp.555-62, 2001.
DOI : 10.1016/S0955-0674(00)00251-9

S. Frisch, K. Vuori, E. Ruoslahti, C. , and P. , Control of adhesion-dependent cell survival by focal adhesion kinase, The Journal of Cell Biology, vol.134, issue.3, pp.793-802, 1996.
DOI : 10.1083/jcb.134.3.793

C. Gaggioli, G. Robert, C. Bertolotto, O. Bailet, A. P. Spadafora et al., Tumor-Derived Fibronectin Is Involved in Melanoma Cell Invasion and Regulated by V600E B-Raf Signaling Pathway, Journal of Investigative Dermatology, vol.127, issue.2, pp.400-410, 2007.
DOI : 10.1038/sj.jid.5700524

J. Gallardo-perez, M. Espinosa, G. Ceballos-cancino, A. Daniel, S. Rodriguez-enriquez et al., NF-kappa B is required for the development of tumor spheroids, Journal of Cellular Biochemistry, vol.27, issue.1, pp.169-180, 2009.
DOI : 10.1002/jcb.22237

A. Garcia, M. Vega, and D. Boettiger, Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation, Molecular Biology of the Cell, vol.10, issue.3, pp.785-98, 1999.
DOI : 10.1091/mbc.10.3.785

T. Geiger and D. Peeper, Metastasis mechanisms, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1796, issue.2, 2009.
DOI : 10.1016/j.bbcan.2009.07.006

J. Gekas, M. Hindie, N. Faucheux, O. Lanvin, C. Maziere et al., The inhibition of cell spreading on a cellulose substrate (cuprophan) induces an apoptotic process via a mitochondria-dependent pathway FEBS Lett, pp.103-110, 2004.

A. Gilmore, Anoikis Cell Death Differ, pp.1473-1480, 2005.

V. Golubovskaya, L. Beviglia, L. Xu, H. Earp, R. Craven et al., Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells, Journal of Biological Chemistry, vol.277, issue.41, pp.38978-87, 2002.
DOI : 10.1074/jbc.M205002200

V. Golubovskaya, R. Finch, and W. Cance, Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53, Journal of Biological Chemistry, vol.280, issue.26, pp.25008-25029, 2005.
DOI : 10.1074/jbc.M414172200

T. Gomez-del-pulgar, S. Benitah, P. Valeron, C. Espina, and J. Lacal, Rho GTPase expression in tumourigenesis: Evidence for a significant link, BioEssays, vol.62, issue.6, pp.602-615, 2005.
DOI : 10.1002/bies.20238

M. Grabacka, P. Plonka, K. Urbanska, and K. Reiss, Peroxisome Proliferator-Activated Receptor ?? Activation Decreases Metastatic Potential of Melanoma Cells In vitro via Down-Regulation of Akt, Clinical Cancer Research, vol.12, issue.10, pp.3028-3064, 2006.
DOI : 10.1158/1078-0432.CCR-05-2556

G. Gronowicz and M. Mccarthy, Response of human osteoblasts to implant materials: Integrin-mediated adhesion, Journal of Orthopaedic Research, vol.92, issue.6, pp.878-87, 1996.
DOI : 10.1002/jor.1100140606

J. Grossmann, Molecular mechanisms of "detachment-induced apoptosis--Anoikis, APOPTOSIS, vol.7, issue.3, pp.247-60, 2002.
DOI : 10.1023/A:1015312119693

J. Grossmann, M. Artinger, A. Grasso, H. Kung, J. Scholmerich et al., Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells Gastroenterology, pp.79-88, 2001.

N. Hail, J. Carter, B. Konopleva, M. Andreeff, and M. , Apoptosis effector mechanisms: A requiem performed in different keys, Apoptosis, vol.4, issue.182, pp.889-904, 2006.
DOI : 10.1007/s10495-006-6712-8

S. Han, C. Lee, M. Kang, Y. Yoon, J. Kang et al., Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions Cancer Lett, pp.264-73, 2006.

M. Hanada, J. Feng, and B. Hemmings, Structure, regulation and function of PKB/AKT???a major therapeutic target, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.3-16, 2004.
DOI : 10.1016/j.bbapap.2003.11.009

D. Hanahan and R. Weinberg, The hallmarks of cancer Cell, pp.57-70, 2000.

P. Hawkins, K. Anderson, K. Davidson, and L. Stephens, Signalling through Class I PI3Ks in mammalian cells, Biochemical Society Transactions, vol.34, issue.5, pp.647-62, 2006.
DOI : 10.1042/BST0340647

J. Heino and J. Kapyla, Cellular Receptors of Extracellular Matrix Molecules, Current Pharmaceutical Design, vol.15, issue.12, pp.1309-1326, 2009.
DOI : 10.2174/138161209787846720

A. Hess, L. Postovit, N. Margaryan, E. Seftor, G. Schneider et al., Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype, Cancer Research, vol.65, issue.21, pp.9851-60, 2005.
DOI : 10.1158/0008-5472.CAN-05-2172

M. Hindie, M. Vayssade, M. Dufresne, S. Queant, R. Warocquier-clerout et al., Interactions of B16F10 melanoma cells aggregated on a cellulose substrate, Journal of Cellular Biochemistry, vol.116, issue.1, pp.96-104, 2006.
DOI : 10.1002/jcb.20833
URL : https://hal.archives-ouvertes.fr/hal-00115886

M. Hindie, G. Legeay, M. Vayssade, R. Warocquier-clérout, and M. Nagel, Culture of melanoma cells as aggregates on cellulose substratum, Biomolecular Engineering, vol.22, issue.5-6, pp.205-213, 2005.
DOI : 10.1016/j.bioeng.2005.07.002
URL : https://hal.archives-ouvertes.fr/hal-00017282

T. Ho, S. Merajver, C. Lapiere, B. Nusgens, and C. Deroanne, RhoA-GDP Regulates RhoB Protein Stability: POTENTIAL INVOLVEMENT OF RhoGDI??, Journal of Biological Chemistry, vol.283, issue.31, pp.21588-98, 2008.
DOI : 10.1074/jbc.M710033200

A. Hoque, H. Chen, and X. Xu, Statin Induces Apoptosis and Cell Growth Arrest in Prostate Cancer Cells, Cancer Epidemiology Biomarkers & Prevention, vol.17, issue.1, pp.88-94, 2008.
DOI : 10.1158/1055-9965.EPI-07-0531

A. Houghton and D. Polsky, Focus on melanoma Cancer Cell, pp.275-283, 2002.

A. Howe, A. Aplin, S. Alahari, and R. Juliano, Integrin signaling and cell growth control, Current Opinion in Cell Biology, vol.10, issue.2, pp.220-251, 1998.
DOI : 10.1016/S0955-0674(98)80144-0

T. Hsieh, P. Wu, S. Park, and J. Wu, Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity??? (PSP), BMC Complementary and Alternative Medicine, vol.224, issue.Suppl 2, p.30, 2006.
DOI : 10.1186/1472-6882-6-30

L. Hu, C. Zaloudek, G. Mills, J. Gray, and R. Jaffe, In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002) Clin Cancer Res, pp.880-886, 2000.

M. Humphries, P. Mcewan, S. Barton, P. Buckley, J. Bella et al., Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble, Trends in Biochemical Sciences, vol.28, issue.6, pp.313-333, 2003.
DOI : 10.1016/S0968-0004(03)00112-9

S. Huveneers and E. Danen, Adhesion signaling - crosstalk between integrins, Src and Rho, Journal of Cell Science, vol.122, issue.8, pp.1059-69, 2009.
DOI : 10.1242/jcs.039446

R. Hynes, Integrins, Cell, vol.110, issue.6, pp.673-87, 2002.
DOI : 10.1016/S0092-8674(02)00971-6

K. Jiang, J. Sun, J. Cheng, J. Djeu, S. Wei et al., Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis, Molecular and Cellular Biology, vol.24, issue.12, pp.5565-76, 2004.
DOI : 10.1128/MCB.24.12.5565-5576.2004

Z. Jin and W. El-deiry, Overview of cell death signaling pathways, Cancer Biology & Therapy, vol.4, issue.2, pp.139-63, 2005.
DOI : 10.4161/cbt.4.2.1508

R. Karlsson, E. Pedersen, Z. Wang, and C. Brakebusch, Rho GTPase function in tumorigenesis, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1796, issue.2, 2009.
DOI : 10.1016/j.bbcan.2009.03.003

M. Kaspar, L. Zardi, and D. Neri, Fibronectin as target for tumor therapy, International Journal of Cancer, vol.13, issue.Suppl 1, pp.1331-1340, 2006.
DOI : 10.1002/ijc.21677

J. Kerr, A. Wyllie, and A. Currie, Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics, British Journal of Cancer, vol.26, issue.4, pp.239-57, 1972.
DOI : 10.1038/bjc.1972.33

B. Kim and D. Mooney, Development of biocompatible synthetic extracellular matrices for tissue engineering TIBTECH, pp.224-254, 1998.

G. Kroemer, W. El-deiry, P. Golstein, M. Peter, D. Vaux et al., Classification of cell death: recommendations of the Nomenclature Committee on Cell Death Cell Death Differ, pp.1463-1470, 2005.

K. Kulasekara, O. Lukandu, E. Neppelberg, O. Vintermyr, A. Johannessen et al., Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer, Archives of Oral Biology, vol.54, issue.10, pp.924-955, 2009.
DOI : 10.1016/j.archoralbio.2009.07.004

M. Kupferman, V. Patel, V. Sriuranpong, P. Amornphimoltham, S. Jasser et al., Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma, Oral Oncology, vol.43, issue.5, pp.440-54, 2007.
DOI : 10.1016/j.oraloncology.2006.04.016

M. Larsen, V. Artym, J. Green, and K. Yamada, The matrix reorganized: extracellular matrix remodeling and integrin signaling, Current Opinion in Cell Biology, vol.18, issue.5, pp.463-71, 2006.
DOI : 10.1016/j.ceb.2006.08.009

L. Gall, M. Chambard, J. Breittmayer, J. Grall, D. Pouyssegur et al., The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal, Molecular Biology of the Cell, vol.11, issue.3, pp.1103-1115, 2000.
DOI : 10.1091/mbc.11.3.1103

J. Lee, L. Bankston, M. Arnaout, and R. Liddington, Two conformations of the integrin A-domain (I-domain): a pathway for activation?, Structure, vol.3, issue.12, pp.1333-1373, 1995.
DOI : 10.1016/S0969-2126(01)00271-4

F. Lejeune, D. Rimoldi, and D. Speiser, New approaches in metastatic melanoma: biological and molecular targeted therapies, Expert Review of Anticancer Therapy, vol.7, issue.5, pp.701-714, 2007.
DOI : 10.1586/14737140.7.5.701

C. Lengsfeld, F. Titgemeyer, G. Faller, and A. Hensel, to Human Gastric Mucosa, Journal of Agricultural and Food Chemistry, vol.52, issue.6, pp.1495-503, 2004.
DOI : 10.1021/jf030666n

H. Lerat, J. Lissitzky, J. Singer, A. Keating, P. Herve et al., Role of stromal cells and macrophages in fibronectin biosynthesis and matrix assembly in human long-term marrow cultures Blood, pp.1480-92, 1993.

M. Leverkus and H. Gollnick, ???Bak (and Bax) to the Future??? ??? of Primary Melanoma Prognosis?, Journal of Investigative Dermatology, vol.126, issue.6, pp.1212-1216, 2006.
DOI : 10.1038/sj.jid.5700239

G. Li, H. Schaider, K. Satyamoorthy, Y. Hanakawa, K. Hashimoto et al., Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development Oncogene, pp.8125-8160, 2001.

G. Liu, X. Meng, Y. Jin, J. Bai, Y. Zhao et al., Inhibitory role of focal adhesion kinase on anoikis in the lung cancer cell A549, Cell Biology International, vol.32, issue.6, pp.663-70, 2008.
DOI : 10.1016/j.cellbi.2008.01.292

W. Liu, S. Cheng, S. Asa, and S. Ezzat, The Melanoma-Associated Antigen A3 Mediates Fibronectin-Controlled Cancer Progression and Metastasis, Cancer Research, vol.68, issue.19, pp.8104-8116, 2008.
DOI : 10.1158/0008-5472.CAN-08-2132

R. Lock and W. Ross, Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells, Cancer Res, vol.50, pp.767-71, 1990.

J. Lomas, P. Martin-duque, M. Pons, and M. Quintanilla, The genetics of malignant melanoma, Frontiers in Bioscience, vol.Volume, issue.13, pp.5071-93, 2008.
DOI : 10.2741/3065

C. Lombello, S. Malmonge, and M. Wada, PolyHEMA and polyHEMApoly(MMA-co-AA ) as substrates for culturing Vero cells, Journal of Materials Science: Materials in Medicine, vol.11, issue.9, pp.541-547, 2000.
DOI : 10.1023/A:1008915801187

B. Manning, A. Tee, M. Logsdon, J. Blenis, and L. Cantley, Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway, Molecular Cell, vol.10, issue.1, pp.151-62, 2002.
DOI : 10.1016/S1097-2765(02)00568-3

K. Mcclary, T. Ugarova, and D. Grainger, Modulating fibroblast adhesion, spreading, and proliferation using self-assembled monolayer films of alkylthiolates on gold, Journal of Biomedical Materials Research, vol.20, issue.3, pp.428-467, 2000.
DOI : 10.1002/(SICI)1097-4636(20000605)50:3<428::AID-JBM18>3.0.CO;2-H

J. Meredith, J. Fazeli, B. Schwartz, and M. , The extracellular matrix as a cell survival factor., Molecular Biology of the Cell, vol.4, issue.9, pp.953-61, 1993.
DOI : 10.1091/mbc.4.9.953

J. Michel, Anoikis in the Cardiovascular System: Known and Unknown Extracellular Mediators, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.23, issue.12, pp.2146-54, 2003.
DOI : 10.1161/01.ATV.0000099882.52647.E4

C. Mitsiades, N. Mitsiades, and M. Koutsilieris, The Akt pathway: molecular targets for anti-cancer drug development Curr Cancer Drug Targets, pp.235-56, 2004.

D. Mohnen, Pectin structure and biosynthesis, Current Opinion in Plant Biology, vol.11, issue.3, pp.266-77, 2008.
DOI : 10.1016/j.pbi.2008.03.006

A. Mould, S. Barton, J. Askari, S. Craig, and M. Humphries, Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin ??5??1, Journal of Biological Chemistry, vol.278, issue.51, pp.51622-51631, 2003.
DOI : 10.1074/jbc.M306655200

W. Mueller-klieser, Three-dimensional cell cultures: from molecular mechanisms to clinical applications, Am J Physiol, vol.273, pp.1109-1132, 1997.

M. Muzio, B. Stockwell, H. Stennicke, G. Salvesen, and V. Dixit, An Induced Proximity Model for Caspase-8 Activation, Journal of Biological Chemistry, vol.273, issue.5, pp.2926-2956, 1998.
DOI : 10.1074/jbc.273.5.2926

M. Nagel, R. Verhoef, H. Schols, M. Morra, J. Knox et al., Enzymatically-tailored pectins differentially influence the morphology, adhesion, cell cycle progression and survival of fibroblasts, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1780, issue.7-8, pp.995-1003, 2008.
DOI : 10.1016/j.bbagen.2008.04.002
URL : https://hal.archives-ouvertes.fr/hal-00308499

C. Nelson and C. Chen, Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal, FEBS Letters, vol.10, issue.2-3, pp.238-280, 2002.
DOI : 10.1016/S0014-5793(02)02370-0

E. Olano-martin, G. Rimbach, G. Gibson, and R. Rastall, Pectin and pecticoligosaccharides induce apoptosis in in vitro human colonic adenocarcinoma cells, Anticancer Res, vol.23, pp.341-347, 2003.

B. Park, X. Zeng, and R. Glazer, Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells, Cancer Res, vol.61, pp.7647-53, 2001.

S. Persad, S. Attwell, V. Gray, M. Delcommenne, A. Troussard et al., Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells, Proceedings of the National Academy of Sciences, vol.97, issue.7, pp.3207-3219, 2000.
DOI : 10.1073/pnas.97.7.3207

C. Peyssonnaux and A. Eychene, The Raf/MEK/ERK pathway: new concepts of activation, Biology of the Cell, vol.93, issue.1-2, pp.53-62, 2001.
DOI : 10.1016/S0248-4900(01)01125-X

A. Philchenkov, Caspases: potential targets for regulating cell death, Journal of Cellular and Molecular Medicine, vol.25, issue.4, pp.432-476, 2004.
DOI : 10.1023/A:1023635510363

A. Philchenkov, M. Zavelevich, T. Kroczak, and M. Los, Caspases and cancer: mechanisms of inactivation and new treatment modalities, Exp Oncol, vol.26, pp.82-97, 2004.

J. Rajeswari and G. Pande, Direct association between caspase 3 and ??5??1 integrin and its role during anoikis of rat fibroblasts, Cell Biology International, vol.30, issue.12, pp.963-972, 2006.
DOI : 10.1016/j.cellbi.2006.06.022

J. Rak, Y. Mitsuhashi, C. Sheehan, J. Krestow, V. Florenes et al., Collateral expression of proangiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis Neoplasia, pp.23-30, 1999.

A. Ratheesh, A. Ingle, and R. Gude, Pentoxifylline modulates cell surface integrin expression and integrin mediated adhesion of B16F10 cells to extracellular matrix components, Cancer Biology & Therapy, vol.6, issue.11, pp.1743-52, 2007.
DOI : 10.4161/cbt.6.11.4833

P. Reddig and R. Juliano, Clinging to life: cell to matrix adhesion and cell survival Cancer Metastasis Rev, pp.425-464, 2005.

B. Ridley, O. Neill, M. Mohnen, and D. , Pectins: structure, biosynthesis, and oligogalacturonide-related signaling, Phytochemistry, vol.57, issue.6, pp.929-67, 2001.
DOI : 10.1016/S0031-9422(01)00113-3

S. Riedl and Y. Shi, Molecular mechanisms of caspase regulation during apoptosis, Nature Reviews Molecular Cell Biology, vol.11, issue.11, pp.897-907, 2004.
DOI : 10.1107/S0021889891004399

M. Romagnoli, C. Seveno, R. Bataille, and S. Barille-nion, [Survivin in cancerology : molecular aspects and therapeutic applications, Med Sci, vol.24, pp.821-828, 2008.

C. Roskelley and M. Bissell, Dynamic reciprocity revisited: a continuous, bidirectional flow of information between cells and the extracellular matrix regulates mammary epithelial cell function, Biochemistry and Cell Biology, vol.73, issue.7-8, pp.391-398, 1995.
DOI : 10.1139/o95-046

A. Russo, E. Torrisi, Y. Bevelacqua, R. Perrotta, M. Libra et al., Melanoma: molecular pathogenesis and emerging target therapies (Review, Int J Oncol, vol.34, pp.1481-1490, 2009.

G. Sarrabayrouse, C. Synaeve, K. Leveque, G. Favre, and A. Tilkin-mariame, Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells Neoplasia, pp.1078-90, 2007.

G. Schneider and K. Burridge, Formation of Focal Adhesions by Osteoblasts Adhering to Different Substrata, Experimental Cell Research, vol.214, issue.1, pp.264-273, 1994.
DOI : 10.1006/excr.1994.1257

A. Schulze, K. Lehmann, H. Jefferies, M. Mcmahon, and J. Downward, Analysis of the transcriptional program induced by Raf in epithelial cells, Genes & Development, vol.15, issue.8, pp.981-94, 2001.
DOI : 10.1101/gad.191101

E. Segal-bendirdjian, C. Dudognon, J. Mathieu, J. Hillion, and F. Besancon, [Cell death signalling: recent advances and therapeutic application, Bull Cancer, vol.92, pp.23-35, 2005.

C. Simpson, K. Anyiwe, and A. Schimmer, Anoikis resistance and tumor metastasis Cancer Lett, pp.177-85, 2008.

D. Siwak, S. Shishodia, B. Aggarwal, and R. Kurzrock, Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression if IKB kinase and Nuclear Factor KB activity and are independent of the B-Raf/Mitogen Activated/Extracellular signal-Regulated protein kinase pathways and the AKT pathway Cancer, pp.879-90, 2005.

K. Smalley, Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy, Journal of Investigative Dermatology, vol.130, issue.1, 2009.
DOI : 10.1038/jid.2009.177

K. Smalley, N. Haass, P. Brafford, M. Lioni, K. Flaherty et al., Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases, Molecular Cancer Therapeutics, vol.5, issue.5, pp.1136-1180, 2006.
DOI : 10.1158/1535-7163.MCT-06-0084

J. Steele, B. Dalton, G. Johnson, and P. Underwood, Polystyrene chemistry affects vitronectin activity: An explanation for cell attachment to tissue culture polystyrene but not to unmodified polystyrene, Journal of Biomedical Materials Research, vol.100, issue.7, pp.927-967, 1993.
DOI : 10.1002/jbm.820270712

J. Steele, B. Dalton, G. Johnson, and P. Underwood, Adsorption of fibronectin and vitronectin onto Primaria and tissue culture polystyrene and relationship to the mechanism of initial attachment of human vein endothelial cells and BHK-21 fibroblasts Biomaterials, pp.1057-67, 1995.

J. Steele, C. Mcfarland, B. Dalton, G. Johnson, M. Evans et al., Attachment of human bone cells to tissue culture polystyrene and to unmodified polystyrene: the effect of surface chemistry upon initial cell attachment, Journal of Biomaterials Science, Polymer Edition, vol.24, issue.3, pp.245-57, 1993.
DOI : 10.1163/156856293X00339

D. Stupack, Integrins as a distinct subtype of dependence receptors Cell Death Differ, pp.1021-1051, 2005.

M. Sun, G. Wang, J. Paciga, R. Feldman, Z. Yuan et al., AKT1/PKB?? Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells, The American Journal of Pathology, vol.159, issue.2, pp.431-438, 2001.
DOI : 10.1016/S0002-9440(10)61714-2

E. Swan, S. Jasser, F. Holsinger, D. Doan, C. Bucana et al., Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer, Oral Oncology, vol.39, issue.7, pp.648-55, 2003.
DOI : 10.1016/S1368-8375(03)00049-6

J. Testa and A. Bellacosa, AKT plays a central role in tumorigenesis, Proceedings of the National Academy of Sciences, vol.98, issue.20, pp.10983-10988, 2001.
DOI : 10.1073/pnas.211430998

N. Thornberry and Y. Lazebnik, Caspases: enemies within Science, pp.1312-1318, 1998.
DOI : 10.1126/science.281.5381.1312

M. Tibbitt and K. Anseth, Hydrogels as extracellular matrix mimics for 3D cell culture, Biotechnology and Bioengineering, vol.17, issue.13, pp.655-63, 2009.
DOI : 10.1002/bit.22361

K. Tsutsumi, T. Kasaoka, H. Park, H. Nishiyama, M. Nakajima et al., Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase, International Journal of Oncology, vol.33, pp.215-239, 2008.
DOI : 10.3892/ijo.33.1.215

P. Vachon, [Cell survival: differences and differentiation, Med Sci, vol.22, pp.423-432, 2006.

M. Van-de-craen, W. Declercq, I. Van-den-brande, W. Fiers, and P. Vandenabeele, The proteolytic procaspase activation network: an in vitro analysis, Cell Death and Differentiation, vol.6, issue.11, pp.1117-1141, 1999.
DOI : 10.1038/sj.cdd.4400589

M. Vayssade, N. S. , R. V. , C. D. , O. G. et al., Antiproliferative and proapoptotic actions of Okra pectin on B16F10 melanoma cells Phytotherapie research, 2009.

F. Vega and A. Ridley, Rho GTPases in cancer cell biology FEBS Lett, pp.2093-101, 2008.

E. Velzenberger, M. Vayssade, G. Legeay, and M. Nagel, Study of cell behaviour on a cellulose anti-adhesive substratum, Cellulose, vol.3, issue.2, pp.347-357, 2008.
DOI : 10.1007/s10570-007-9182-4
URL : https://hal.archives-ouvertes.fr/hal-00308665

V. Herbay, A. Rudi, and J. , Role of apoptosis in gastric epithelial turnover, Microscopy Research and Technique, vol.43, issue.5, pp.303-314, 2000.
DOI : 10.1002/(SICI)1097-0029(20000301)48:5<303::AID-JEMT7>3.0.CO;2-X

S. Westfall and M. Skinner, Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment, Molecular Cancer Therapeutics, vol.4, issue.11, pp.1764-71, 2005.
DOI : 10.1158/1535-7163.MCT-05-0192

I. Wierzbicka-patynowski and J. Schwarzbauer, The ins and outs of fibronectin matrix assembly, Journal of Cell Science, vol.116, issue.16, pp.3269-76, 2003.
DOI : 10.1242/jcs.00670

R. Wong, P. Ng, S. Dedhar, and L. G. , The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth, Molecular Cancer Therapeutics, vol.6, issue.6, pp.1692-700, 2007.
DOI : 10.1158/1535-7163.MCT-07-0134

J. Woodgett, Recent advances in the protein kinase B signaling pathway, Current Opinion in Cell Biology, vol.17, issue.2, pp.150-157, 2005.
DOI : 10.1016/j.ceb.2005.02.010

M. Wozniak, K. Modzelewska, L. Kwong, and P. Keely, Focal adhesion regulation of cell behavior, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1692, issue.2-3, pp.103-122, 2004.
DOI : 10.1016/j.bbamcr.2004.04.007

K. Yamada and E. Cukierman, Modeling tissue morphogenesis and cancer in 3D Cell, pp.601-611, 2007.

D. Yamazaki, S. Kurisu, and T. Takenawa, Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates Oncogene, pp.1570-83, 2009.

C. Yu, M. Rahmani, P. Dent, and G. S. , The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib, Experimental Cell Research, vol.295, issue.2, pp.555-66, 2004.
DOI : 10.1016/j.yexcr.2004.02.001

E. Zamir and B. Geiger, Molecular complexity and dynamics of cell-matrix adhesions, J Cell Sci, vol.114, pp.3583-90, 2001.

Y. Zhang, H. Lu, P. Dazin, and Y. Kapila, Squamous Cell Carcinoma Cell Aggregates Escape Suspension-induced, p53-mediated Anoikis: FIBRONECTIN AND INTEGRIN ??v MEDIATE SURVIVAL SIGNALS THROUGH FOCAL ADHESION KINASE, Journal of Biological Chemistry, vol.279, issue.46, pp.48342-48351, 2004.
DOI : 10.1074/jbc.M407953200

C. Zheng and K. Guan, Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases, J Biol Chem, vol.268, pp.23933-23942, 1993.

C. Zheng and K. Guan, Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues, Embo J, vol.13, pp.1123-1154, 1994.

O. Goundiam, M. D. Nagel, M. Vayssade, O. Goundiam, M. D. Nagel et al., Growth and survival signaling in B16F10 melanoma cells in 3D architecture Cell Biology International (accepté) Communications internationales avec actes et comités de lecture Study of melanoma cell survival in a 3D architecture 7ème congrès mondial sur le mélanome, Antiproliferative and proapoptotic actions of Okra pectin on B16F10 melanoma cells, pp.12-16, 2009.

O. Goundiam, M. D. Nagel, and M. Vayssade, Study of cancer cell survival using an anti-adhesive substratum 33ème Congrès de la Société de Biomécanique, 1-3 Septembre, Computer Methods in Biomechanics and Biomedical Engineering, vol.1, pp.105-106, 2008.

G. Autres-communications-farges, H. Brockaert, T. T. Dao, and O. Goundiam, Contribution aux bonnes pratiques en recherche biomédicale : acteurs et processus de publication, IRBM- NEWS vol, vol.28, issue.4, 2007.