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Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium

Abstract : Toll-like receptors (TLRs) recognize a wide range of microbial pathogens and their products modulate the innate immune response that may lead to inflammation. In order to better understand the host-pathogen relationship, we have studied the implication of the co-receptor CD14 in the innate immune response to Listeria monocytogenes and to the bacterial flagellin from Salmonella typhimurium. Our results clearly show that TLR2 requires CD14 to control Listeria infection whereas TLR5 does not. Moreover, TLR activation leads to pro-inflammatory cytokines production such as Tumor Necrosis Factor (TNF). This pleiotropic protein is required for normal development and function of the immune system. TNF can be secreted (sTNF) or associated to the membrane (Mem-TNF). Our results suggest that Mem-TNF can activate the synthesis of cytokines and chemicals mediators of inflammation and partially protect mice from a moderate infection. These experiments open new avenues for the treatment of inflammatory disease like rheumatoid arthritis or Crohn disease.
Keywords : Flagellin Tlr2
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https://tel.archives-ouvertes.fr/tel-00452680
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Laure Janot. Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium. Sciences agricoles. Université d'Orléans, 2009. Français. ⟨NNT : 2009ORLE2014⟩. ⟨tel-00452680⟩

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