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Dialogues entre les voies de signalisation de l'AMPc et celles de l'IL-1 dans la régulation de l'expression de l'IL-6 et rôle de l'IL-6 dans les thyrocytes et dans les cardiomyocytes.

Abstract : The interleukin-6 (IL-6) is a cytokine associated with auto-immune thyroid diseases and could be also involved in pathological cardiac hypertrophy. In FRTL-5 thyroid cells and in adult rat cardiomyocytes, we show that both IL-6 secretion and mRNA expression, stimulated by interleukin-1 (IL-1), are enhanced by cAMP/PKA pathway in a synergistic manner. In FRTL-5 cells, this synergistic effect occurs also at a post-transcriptional level by increasing IL-6 promoter activation. This synergic effect involves AP-1 and CRE binding sites of IL-6 promoter and also c-Fos and Fra2 transcription factors. IL-6 and its membrane-bound receptor stimulate STAT3 and ERK-5 signaling pathways in FRTL-5 cells. In cardiomyocytes, STAT3 is activated by IL-6 only in the presence of its soluble receptor. We show that this mechanism conduces to increase protein synthesis and expression of markers associated to the pathological hypertrophy.
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https://tel.archives-ouvertes.fr/tel-00451370
Contributor : Nicolas Szabo <>
Submitted on : Thursday, January 28, 2010 - 7:40:31 PM
Last modification on : Wednesday, September 16, 2020 - 4:54:13 PM
Long-term archiving on: : Friday, June 18, 2010 - 5:19:11 PM

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  • HAL Id : tel-00451370, version 1

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Nicolas Szabo-Fresnais. Dialogues entre les voies de signalisation de l'AMPc et celles de l'IL-1 dans la régulation de l'expression de l'IL-6 et rôle de l'IL-6 dans les thyrocytes et dans les cardiomyocytes.. Biologie cellulaire. Université Paris Sud - Paris XI, 2009. Français. ⟨tel-00451370⟩

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