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Exploration du caractère métallique de l'astate en solution aqueuse

Abstract : Alpha-radiotherapy is an innovative technique for the treatment of cancers complementary to current approaches. The principle is to use tumor-specific vectors labeled with alpha-radioisotopes. Astatine 211 is a very promising candidate if one considers the energy of the α particles emitted as well as its physical half-life (7.2 h). One of the ways of labeling is to use astatine at a higher oxidation state as a “metal cation”. Indeed, considering its location in the periodic table. astatine is supposed to present a more metallic character than the other halogens. This way of labeling has however never been explored. This can be explained by the fact that the astatine chemistry is nearly unknown. The purpose of this work was therefore to explore this property of astatine and to define its Eh, pH diagram (or Pourbaix diagram) in non complexing aqueous solution. To this end, both experimental and theoretical approaches were used. The experimental approach uses competition methods to identify the formed species and the thermodynamics constants of studied equilibria. The theoretical approach uses methods of computational chemistry and provides information at the molecular scale on the studied systems in order to predict thermodynamic data which are used as support and complement to the experimental approach. The important result of this work shows the presence of two stable cationic forms of astatine in aqueous solution, i.e., At+ and AtO+.
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Submitted on : Wednesday, January 27, 2010 - 4:13:01 PM
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  • HAL Id : tel-00450909, version 1


Julie Champion. Exploration du caractère métallique de l'astate en solution aqueuse. Autre. Université de Nantes, 2009. Français. ⟨tel-00450909⟩



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