Skip to Main content Skip to Navigation
Theses

New biopolymers with possible use in dentistry and orthopaedics

Abstract : The present thesis focuses on the use of biocompatible polymers in controlled drug delivery applications. The principles of controlled drug delivery are outlined and applications of polymers are described. Series of HEMA-based copolymers were synthesized by suspension-dispersion polymerization, precipitant polymerization and bulk polymerization. Functionalisation was given by introducing monomers such as : methacryloxyethyl phospahte, guanidino-propyl methacrylate, diethylaminoethyl methacrylate, diallyldimethyl ammonium chloride, methacryloyloxyethyl acetoacetate, methacryloyloxyethyl trimethylammonium chloride, glycidyl methacrylate, tetrahydrofurfuryl methacrylate. Polymers were physico-chemically and biologically characterized. Reactivity ratios of monomers in different systems were studied : MMA-TIPA, HEMA-AA, AA-dDMA, HEMA-dDMA-AA. Another approach was the use of HEMA-based copolymers with fluorescent dyes and a iodine MMA-containing copolymer, for biological detection purposes. To obtain active targeting drug-delivery systems, two methods were used : physical binding in case of thalidomide and chemical linkage for nafcillin. drug insertion was determined by FT-IR and UV spectra, confirmed by SEM and EDX. in vitro studies were performed in order to investigate the interactions of these drug-functionalized polymers with cells, in which uptake was followed via FOM, in case of thalidomide, and via UV-VIS studies, in case of nafcillin. No significant cytotoxicity was determined for the artificial polymers in these studies. Drug release results obtained were interesting, giving a real option of future use in the field of tumour antiangiogenesis.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00448235
Contributor : Anne-Marie Plé <>
Submitted on : Monday, January 18, 2010 - 3:15:46 PM
Last modification on : Tuesday, May 7, 2019 - 6:30:13 PM
Long-term archiving on: : Thursday, June 17, 2010 - 10:58:22 PM

Identifiers

  • HAL Id : tel-00448235, version 1

Citation

Teodora Zecheru. New biopolymers with possible use in dentistry and orthopaedics. Chemical Sciences. Université d'Angers, 2008. English. ⟨tel-00448235⟩

Share

Metrics

Record views

310

Files downloads

1422