Skip to Main content Skip to Navigation
Theses

Insulinorésistance et stress oxydant dans le syndrome métabolique : étude expérimentale des effets protecteurs de microconstituants nutritionnels (Polyphénols du thé, de la cannelle et chrome III)

Abstract : The incidence of the metabolic syndrome is increasing in Western countries, leading to high risks of diabetes and cardiovascular diseases. Considering the relationship between insulin resistance and oxidative stress, which are present in the metabolic syndrome, we hypothesized that microconstituants, potentially antioxidant and insulin sensitizers, could be of interest in nutritional prevention of the metabolic syndrome. We focused on green tea extracts, cinnamon extracts, and Chromium III. In an animal model of the metabolic syndrome, the fructose rat, green tea extracts act as antioxidant in protecting lipids, proteins and DNA from oxidative damages, and modulate glucose and lipid metabolism. They activate insulin signalling pathway and modulate the related gene expression. For cinnamon extracts, we show that, in parallel to the insulin potentiating effect, they were powerful antioxidant in animal and in man. Regarding Chromium III, already reported as a strong insulin sensitizer, we have demonstrated the lack of genotoxicity of chromium supplementation using culture cell (HACAT), and the modulation of antioxidant gene expression by chromium histidinate. These experimental data strongly suggest the interest of combined intakes of insulin potentiating and antioxidant nutrients in the prevention of metabolic syndrome. However, with respect to the numerous experimental limits, further interventional trial in man, associating green tea and cinnamon polyphenols and chromium III are needed.
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00447570
Contributor : Rachida Benaraba <>
Submitted on : Friday, January 15, 2010 - 12:56:04 PM
Last modification on : Thursday, November 19, 2020 - 3:52:36 PM
Long-term archiving on: : Friday, June 18, 2010 - 12:59:04 AM

Identifiers

  • HAL Id : tel-00447570, version 1

Collections

UJF | LBFA | UGA

Citation

Rachida Benaraba. Insulinorésistance et stress oxydant dans le syndrome métabolique : étude expérimentale des effets protecteurs de microconstituants nutritionnels (Polyphénols du thé, de la cannelle et chrome III). Biochimie [q-bio.BM]. Université Joseph-Fourier - Grenoble I, 2007. Français. ⟨tel-00447570⟩

Share

Metrics

Record views

1558

Files downloads

10474