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Nouvelles organisations supramoléculaires à base de cycloptides

Abstract : The purpose of my thesis was to realize new hybrid compounds based on carbon nanotubes (or fullerenes) and peptide nanotubes. The chosen approach consisted first in grafting on carbon nanotubes, or at first on fullerene, via linkers, « Ghadiri type » cyclopeptides leading to the peptide nanotubes. On the one hand, the grafting was planned to be done via the introduction of linkers on carbon nanotubes or C60. On the other hand, cyclopeptides are obtained by SPPS using an even number of alternated D and L amino acids auto-assembling in antiparallel ß sheets affording nanotubes after cleavage. Although, we were successful of the first part of this approach, unsolubility of the cyclopeptides in common organic solvents did not allow us to get the target compound. Introduction of C60 during the solid phase synthesis was not more satisfactory. In a second part, I focused on the characterization of two cyclopeptides, by TEM, ATR-FTIR, optical microscopy and light scattering. During there studies, I also evidenced self-assembly. The self-organization can be drive by the counter-ion on (one or two) Glu. In fact, whereas the free acid yields to nanotubes, salification strongly affects the self-assembly loading after crystallization to fractal aggregates. The shapes of these aggregates are also dependent of the counter-ions used. In addition, I also briefly evaluate the potential of some of these cyclopeptides to encapsulate Xe for MRI.
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Submitted on : Thursday, January 14, 2010 - 11:07:22 AM
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  • HAL Id : tel-00447083, version 1



Marie-Laure Bodelec. Nouvelles organisations supramoléculaires à base de cycloptides. Chimie. Université Paris Sud - Paris XI, 2008. Français. ⟨tel-00447083⟩



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