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Génération et analyse fonctionnelle d'antagonistes de l'oncostatine m et de l'interleukine-31, cytokines impliquées dans l'inflammation cutanée et le développement tumoral

Abstract : Oncostatin M (OSM) and interleukin-31 (IL-31), cytokines of the IL-6 family, are involved in inflammation associated with skin diseases such as atopic dermatitis or psoriasis. In a therapeutic perspective, two first studies were based on the generation of antagonists acting as soluble receptors and intended to trap these cytokines. In order to have a new model for the IL-31 in vivo study, we also identified and cloned this protein in rat. In a latest study, we highlighted IL-31 involvement in tumor development by demonstrating its cytostatic activity on tumor cell lines, in a similar way to OSM. This study has also led us to analyze the intracellular signaling pathways involved in these anti-tumor effects and we demonstrated the activation of a new transcription factor in response to these two cytokines.
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https://tel.archives-ouvertes.fr/tel-00445055
Contributor : Anne-Marie Plé <>
Submitted on : Thursday, January 7, 2010 - 4:10:09 PM
Last modification on : Tuesday, May 7, 2019 - 6:30:07 PM
Long-term archiving on: : Thursday, June 17, 2010 - 8:45:19 PM

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  • HAL Id : tel-00445055, version 1

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Emilie Venereau. Génération et analyse fonctionnelle d'antagonistes de l'oncostatine m et de l'interleukine-31, cytokines impliquées dans l'inflammation cutanée et le développement tumoral. Immunologie. Université d'Angers, 2008. Français. ⟨tel-00445055⟩

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