Skip to Main content Skip to Navigation
Theses

Des sPLA2 de venins de serpents à leurs homologues de Mammifères: Rôles de ces enzymes dans la fécondation

Abstract : The fall of the world male fertility these last decades became alarming. Thus, a man on fifteen is subfertile. If the causes of the fall of fertility seem to be mainly related on the environment and the lifestyle, it is essential to understand all the mechanisms which control the fertilizing ability of spermatozoon in order to optimize the techniques of procreation medically assisted. The development of new research orientations, experimental and theoretical, to identify the subjacent mechanisms of male infertility is essential. In this context, development of new experimental strategies that is situated this work of thesis. The strategy that I employed here is research new pharmacological tools starting from venom of animals by tests of biological activities. This research allowed us to discover a new regulatory pathway of sperm physiology involving secreted phospholipases A2. Thus, we showed for the first time that secreted phospholipases A2 regulate four key events of sperm physiology: Capacitation Acrosome reaction, sperm motility and gamete interaction.
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00441813
Contributor : Jessica Escoffier <>
Submitted on : Thursday, December 17, 2009 - 12:31:13 PM
Last modification on : Friday, November 6, 2020 - 4:09:34 AM
Long-term archiving on: : Thursday, June 17, 2010 - 11:48:56 PM

Identifiers

  • HAL Id : tel-00441813, version 1

Collections

UJF | U836 | UGA

Citation

Jessica Escoffier. Des sPLA2 de venins de serpents à leurs homologues de Mammifères: Rôles de ces enzymes dans la fécondation. Physiologie [q-bio.TO]. Université Joseph-Fourier - Grenoble I, 2009. Français. ⟨tel-00441813⟩

Share

Metrics

Record views

403

Files downloads

1383