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Theses

Mécanismes moléculaires de la résistance aux antifongiques chez candida glabrata

Abstract : Candida glabrata, which ranks the second among the causative agents of candidiasis in all clinical forms of the disease, possesses singular traits and determines a greater mortality rate in patients with systemic candidiasis. This species is also less susceptible to azoles, the most used class of antifungals. Moreover, it seems that an acquired resistance to azole, polyene and pyrimidin analog drugs is more frequent in C. glabrata. Thus, we studied clinical isolates as well as laboratory mutants with a resistance to these three classes of antifungal and aimed at determining the molecular mechanisms responsible for their resistance. Classical molecular biology tools revealed in each case a modification in the expression of some genes involved in the metabolism of these drugs or of their target, as well as the presence of a point mutation in these genes. The haploid genome of C. glabrata, with the subsequent higher probability to express a mutated gene, and the actual therapeutic context, which favors prophylactic use of antifungals in immunocompromised patients, represent a privileged environment for the development of a candidiasis and for the simultaneous selection of resistant isolates.
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https://tel.archives-ouvertes.fr/tel-00433842
Contributor : Anne-Marie Plé <>
Submitted on : Sunday, January 1, 2012 - 7:00:04 AM
Last modification on : Wednesday, October 14, 2020 - 4:16:40 AM
Long-term archiving on: : Thursday, June 17, 2010 - 9:06:42 PM

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  • HAL Id : tel-00433842, version 1

Citation

Patrick Vandeputte. Mécanismes moléculaires de la résistance aux antifongiques chez candida glabrata. Interactions entre organismes. Université d'Angers, 2008. Français. ⟨tel-00433842⟩

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