R. J. Albertini, D. Anderson, G. R. Douglas, L. Hagmar, K. Hemminki et al., IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans, Mutation Research/Reviews in Mutation Research, vol.463, issue.2, pp.111-172, 2000.
DOI : 10.1016/S1383-5742(00)00049-1

T. Alper, Cellular Radiobiology, Annual Review of Nuclear Science, vol.10, issue.1, pp.489-530, 1960.
DOI : 10.1146/annurev.ns.10.120160.002421

T. Alper, N. E. Gillies, E. , and M. M. , The Sigmoid Survival Curve in Radiobiology, Nature, vol.167, issue.4730, pp.1062-1063, 1960.
DOI : 10.1038/1861062a0

G. Alphonse, M. T. Aloy, P. Broquet, J. P. Gerard, P. Louisot et al., Ceramide induces activation of the mitochondrial/caspases pathway in jurkat and scc61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant sq20b cells, Int J Radiat Biol, issue.9, pp.78821-835, 2002.

M. Awasthi-kalia, P. P. Schnetkamp, and J. P. Deans, Differential Effects of Filipin and Methyl-??-cyclodextrin on B Cell Receptor Signaling, Biochemical and Biophysical Research Communications, vol.287, issue.1, pp.77-82, 2001.
DOI : 10.1006/bbrc.2001.5536

E. I. Azzam, S. M. De-toledo, T. Gooding, and J. B. And-little, Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles, Radiation Research, vol.150, issue.5, pp.497-504, 1998.
DOI : 10.2307/3579865

E. I. Azzam, S. M. De-toledo, and J. B. And-little, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells, Proceedings of the National Academy of Sciences, vol.98, issue.2, pp.98473-478, 2001.
DOI : 10.1073/pnas.011417098

E. I. Azzam, S. M. De-toledo, and J. B. And-little, Expression of connexin43 is highly sensitive to ionizing radiation and other environmental stresses, Cancer Res, issue.21, pp.637128-7135, 2003.

E. I. Azzam, S. M. De-toledo, and J. B. And-little, Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect, Oncogene, vol.22, issue.45, pp.227050-7057, 2003.
DOI : 10.1038/sj.onc.1206961

E. I. Azzam, S. M. De-toledo, and J. B. And-little, Stress Signaling from Irradiated to Non-Irradiated Cells, Current Cancer Drug Targets, vol.4, issue.1, pp.53-64, 2004.
DOI : 10.2174/1568009043481641

E. I. Azzam, S. M. De-toledo, M. J. Pykett, H. Nagasawa, and J. B. And-little, Cdc2 is down-regulated by ionizing radiation in a p53-dependent manner, Cell Growth Differ, vol.8, issue.11, pp.1161-1169, 1997.

E. I. Azzam, S. M. De-toledo, G. P. Raaphorst, M. , and R. E. , Low-Dose Ionizing Radiation Decreases the Frequency of Neoplastic Transformation to a Level below the Spontaneous Rate in C3H 10T1/2 Cells, Radiation Research, vol.146, issue.4, pp.369-373, 1996.
DOI : 10.2307/3579298

E. I. Azzam, S. M. De-toledo, A. J. Waker, and J. B. And-little, High and low fluences of alpha-particles induce a g1 checkpoint in human diploid fibroblasts, Cancer Res, issue.10, pp.602623-2631, 2000.

E. I. Azzam, I. George, R. , and G. P. , Alteration in Thermal Sensitivity of Chinese Hamster Cells by D 2 O Treatment, Radiation Research, vol.90, issue.3, pp.644-648, 1982.
DOI : 10.2307/3575742

E. I. Azzam and J. B. Little, The radiation-induced bystander effect: evidence and significance, Human & Experimental Toxicology, vol.23, issue.2, pp.61-65, 2004.
DOI : 10.1191/0960327104ht418oa

E. I. Azzam, H. Nagasawa, Y. Yu, C. Li, and J. B. And-little, Cell Cycle Deregulation and Xeroderma Pigmentosum Group C Cell Transformation, Journal of Investigative Dermatology, vol.119, issue.6, pp.1350-1354, 2002.
DOI : 10.1046/j.1523-1747.2002.19628.x

E. I. Azzam, G. P. Raaphorst, M. , and R. E. , Radiation-Induced Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells, Radiation Research, vol.138, issue.1, pp.28-31, 1994.
DOI : 10.2307/3578755

E. I. Azzam, S. M. Toledo, D. R. Spitz, and J. B. And-little, Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures, Cancer Res, issue.19, pp.625436-5442, 2002.

E. I. Azzam, J. A. Vadasz, R. , and G. P. , Thermal Sensitivity and Radiosensitization in Chinese Hamster V79 Cells Exposed to 2-Aminopurine or 6-Thioguanine, Radiation Research, vol.125, issue.2, 1991.
DOI : 10.2307/3577891

C. Ballarin, F. Sarto, L. Giacomelli, G. B. Bartolucci, C. et al., Micronucleated cells in nasal mucosa of formaldehyde-exposed workers, Mutation Research/Genetic Toxicology, vol.280, issue.1, pp.1-7, 1992.
DOI : 10.1016/0165-1218(92)90012-O

P. Barberet, P. Aguer, A. Balana, N. Gault, S. Incerti et al., First experiments on cells using the focused microbeam at cenbg, Radiat Res, vol.161, issue.1, pp.91-93, 2004.
URL : https://hal.archives-ouvertes.fr/in2p3-00020431

G. W. Barendsen, RBE???LET Relationships for Different Types of Lethal Radiation Damage in Mammalian Cells: Comparison with DNA Dsb and an Interpretation of Differences in Radiosensitivity, International Journal of Radiation Biology, vol.104, issue.5, pp.433-436, 1994.
DOI : 10.1080/09553009414551411

G. W. Barendsen, The Relationships between RBE and LET for Different Types of Lethal Damage in Mammalian Cells: Biophysical and Molecular Mechanisms, Radiation Research, vol.139, issue.3, pp.257-270, 1994.
DOI : 10.2307/3578823

S. Barker, M. Weinfeld, J. Zheng, L. Li, M. et al., Identification of Mammalian Proteins Cross-linked to DNA by Ionizing Radiation, Journal of Biological Chemistry, vol.280, issue.40, pp.28033826-33838, 2005.
DOI : 10.1074/jbc.M502477200

G. Bartosz, Use of spectroscopic probes for detection of reactive oxygen species, Clinica Chimica Acta, vol.368, issue.1-2, pp.53-76, 2006.
DOI : 10.1016/j.cca.2005.12.039

S. Bassal and A. Osta, DNA damage detection and repair, and the involvement of epigenetic states, Human Mutation, vol.19, issue.Pt 19, pp.101-109, 2005.
DOI : 10.1002/humu.20130

G. Bauer, Low dose radiation and intercellular induction of apoptosis: potential implications for the control of oncogenesis, International Journal of Radiation Biology, vol.10, issue.11-12, pp.11-12873, 2007.
DOI : 10.1038/sj.onc.1201989

K. B. Beckman and B. N. Ames, Oxidative Decay of DNA, Journal of Biological Chemistry, vol.272, issue.32, pp.19633-19636, 1997.
DOI : 10.1074/jbc.272.32.19633

J. Beer, Heritable radiation-induced lesions in somatic mammalian cells, Postepy biochemi, vol.14, issue.3, pp.463-472, 1968.

O. V. Belyakov, S. A. Mitchell, D. Parikh, G. Randers-pehrson, S. A. Marino et al., From The Cover: Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away, Proceedings of the National Academy of Sciences, vol.102, issue.40, pp.10214203-14208, 2005.
DOI : 10.1073/pnas.0505020102

M. Benderitter, L. Vincent-genod, A. Berroud, S. Muller, M. Donner et al., Radio-induced structural membrane modifications : a potential bioindicator of ionizing radiation exposure, Int J Radiat Biol, issue.8, pp.751043-1053, 1999.

P. Berger and G. Revel, Microsonde nucléaire principe et appareillage, 2005.

A. Bigelow, G. Ross, G. Randers-pehrson, and D. Brenner, The columbia university microbeam ii endstation for cell imaging and irradiation. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.231202-206, 2005.

A. W. Bigelow, D. J. Brenner, G. Garty, and G. Randers-pehrson, Single-Particle/Single-Cell Ion Microbeams as Probes of Biological Mechanisms, IEEE Transactions on Plasma Science, vol.36, issue.4, pp.1424-1431, 2008.
DOI : 10.1109/TPS.2008.927268

A. Bishayee, H. Z. Hill, D. Stein, D. V. Rao, and R. W. Howell, Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model, Radiation Research, vol.155, issue.2, pp.335-344, 2001.
DOI : 10.1667/0033-7587(2001)155[0335:FRIAGJ]2.0.CO;2

W. Bloom and R. E. Zirkle, Irradiation of small parts of dividing cells, Proc Inst Med Chic, vol.20, issue.5, pp.119-120, 1954.

B. Bloom, W. Zirkle, R. E. Urezt, and R. B. , IRRADIATION OF PARTS OF INDIVIDUAL CELLS. III. EFFECTS OF CHROMOSOMAL AND EXTRACHROMOSOMAL IRRADIATION ON CHROMOSOME MOVEMENTS, Annals of the New York Academy of Sciences, vol.2, issue.4, pp.503-513, 1955.
DOI : 10.1111/j.1749-6632.1955.tb45966.x

A. Boneh, Regulation of mitochondrial oxidative phosphorylation by second messenger-mediated signal transduction mechanisms, Cellular and Molecular Life Sciences, vol.63, issue.11, pp.1236-1248, 2006.
DOI : 10.1007/s00018-005-5585-2

M. G. Bonini, C. Rota, A. Tomasi, and R. P. Mason, The oxidation of 2???,7???-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy?, Free Radical Biology and Medicine, vol.40, issue.6, pp.40968-975, 2006.
DOI : 10.1016/j.freeradbiomed.2005.10.042

D. J. Brenner and E. J. Hall, Microbeams: A Potent Mix of Physics and Biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response, Radiation Protection Dosimetry, vol.99, issue.1, pp.1-4283, 2002.
DOI : 10.1093/oxfordjournals.rpd.a006785

S. Burdak-rothkamm, K. Rothkamm, and K. M. Prise, ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells, Cancer Research, vol.68, issue.17, pp.687059-7065, 2008.
DOI : 10.1158/0008-5472.CAN-08-0545

C. Burrows and J. Muller, Oxidative Nucleobase Modifications Leading to Strand Scission, Chemical Reviews, vol.98, issue.3, pp.1109-1152, 1998.
DOI : 10.1021/cr960421s

J. Cadet, X. Artignan, M. Berger, T. Douki, M. Gromova et al., Effects of ionising radiation on isolated and cellular DNA, France. Editions de Physique. 27th Annual Meeting of the European Society for Radiation Biology, pp.77-80, 1996.

J. Cadet, S. Bellon, M. Berger, A. Bourdat, T. Douki et al., Recent Aspects of Oxidative DNA Damage: Guanine Lesions, Measurement and Substrate Specificity of DNA Repair Glycosylases, Biological Chemistry, vol.383, issue.6, pp.933-943, 2002.
DOI : 10.1515/BC.2002.100

J. Cadet, S. Bellon, T. Douki, S. Frelon, D. Gasparutto et al., Radiation-Induced DNA Damage: Formation, Measurement, and Biochemical Features, Journal of Environmental Pathology, Toxicology and Oncology, vol.23, issue.1, pp.33-43, 2004.
DOI : 10.1615/JEnvPathToxOncol.v23.i1.30

J. Cadet, T. Douki, D. Gasparutto, R. , and J. , Oxidative damage to DNA : formation, measurement and biochemical features, Mutat Res, vol.531, issue.12, pp.5-23, 2003.
DOI : 10.1142/p607

K. H. Chadwick and H. P. Leenhouts, A molecular theory of cell survival, Physics in Medicine and Biology, vol.18, issue.1, pp.78-87, 1973.
DOI : 10.1088/0031-9155/18/1/007

A. K. Chaudhary, G. R. Reddy, I. A. Blair, and L. J. Marnett, Characterization of an n6-oxopropenyl-2'-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography/electrospray ionization tandem mass spectrometry, Carcinogenesis, issue.5, pp.171167-1170, 1996.

H. J. Chen and F. L. Chung, -4-Hydroxy-2-nonenal by Fatty Acid Hydroperoxides and Hydrogen Peroxide, Chemical Research in Toxicology, vol.9, issue.1, pp.306-312, 1996.
DOI : 10.1021/tx9501389
URL : https://hal.archives-ouvertes.fr/hal-00109057

S. Chen, Y. Zhao, W. Han, G. Zhao, L. Zhu et al., Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects, British Journal of Cancer, vol.57, issue.11, pp.981839-1844, 2008.
DOI : 10.1016/j.yjmcc.2007.05.019

J. E. Cleaver, R. R. Laposa, and C. L. Limoli, DNA Replication in the Face of (In)surmountable Odds, Cell Cycle, vol.2, issue.4, pp.310-315, 2003.
DOI : 10.4161/cc.2.4.436

R. M. Costa, V. Chigan-?-as, R. Da-silva-galhardo, H. Carvalho, and C. F. Menck, The eukaryotic nucleotide excision repair pathway, Biochimie, vol.85, issue.11, pp.851083-1099, 2003.
DOI : 10.1016/j.biochi.2003.10.017

A. Cremesti, F. Paris, H. Grassm?a©grassm?-grassm?a©, N. Holler, J. Tschopp et al., Ceramide Enables Fas to Cap and Kill, Journal of Biological Chemistry, vol.276, issue.26, pp.27623954-23961, 2001.
DOI : 10.1074/jbc.M101866200

A. R. Cuddihy and R. G. Bristow, The p53 protein family and radiation sensitivity: Yes or no?, Cancer and Metastasis Reviews, vol.23, issue.3/4, pp.3-4237, 2004.
DOI : 10.1023/B:CANC.0000031764.81141.e4

M. C. Cummings, C. M. Winterford, and N. I. Walker, Apoptosis, The American Journal of Surgical Pathology, vol.21, issue.1, pp.88-101, 1997.
DOI : 10.1097/00000478-199701000-00010

L. Daudin, M. Carri?a¨recarri?-carri?a¨re, B. Gouget, J. Hoarau, and H. Khodja, Development of a single ion hit facility at the Pierre Sue Laboratory: a collimated microbeam to study radiological effects on targeted living cells, Radiation Protection Dosimetry, vol.122, issue.1-4, pp.1-4310, 2006.
DOI : 10.1093/rpd/ncl481

P. Deschavanne and B. Fertil, A review of human cell radiosensitivity in vitro, International Journal of Radiation Oncology*Biology*Physics, vol.34, issue.1, pp.251-266, 1996.
DOI : 10.1016/0360-3016(95)02029-2

B. Djordjevic, Bystander effects: A concept in need of clarification, BioEssays, vol.147, issue.3, pp.286-290, 2000.
DOI : 10.1002/(SICI)1521-1878(200003)22:3<286::AID-BIES10>3.0.CO;2-S

G. Dollinger, V. Hable, A. Hauptner, R. Krucken, P. Reichart et al., Microirradiation of cells with energetic heavy ions. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.231195-201, 2005.

H. J. Donahue, K. J. Mcleod, C. T. Rubin, J. Andersen, E. A. Grine et al., Cell-to-cell communication in osteoblastic networks: Cell line-dependent hormonal regulation of gap junction function, Journal of Bone and Mineral Research, vol.152, issue.4, pp.881-889, 1995.
DOI : 10.1002/jbmr.5650100609

B. Durand, R. E. Olive, and P. L. , Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342., Journal of Histochemistry & Cytochemistry, vol.30, issue.2, pp.111-116, 1982.
DOI : 10.1177/30.2.7061816

G. O. Edwards, S. W. Botchway, G. Hirst, C. W. Wharton, J. K. Chipman et al., Gap junction communication dynamics and bystander effects from ultrasoft X-rays, British Journal of Cancer, vol.90, issue.7, pp.901450-1456, 2004.
DOI : 10.1038/sj.bjc.6601686

M. Elfman, J. Pallon, V. Auzelyte, P. Kristiansson, K. Malmqvist et al., The lund nuclear microprobe sub-micron set-up. part iii : Sample stage, optical imaging and detector configuration in the experimental chamber. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.23114-23134, 2005.

W. Elkind, The radiobiology of cultured mammalians cells, 1967.

M. M. Elkind, W. B. Moses, S. , and H. , Radiation Response of Mammalian Cells Grown in Culture: VI. Protein, DNA, and RNA Inhibition during the Repair of X-Ray Damage, Radiation Research, vol.31, issue.1, pp.31156-173, 1967.
DOI : 10.2307/3572168

H. M. Ellis and H. R. Horvitz, Genetic control of programmed cell death in the nematode C. elegans, Cell, vol.44, issue.6, pp.817-829, 1986.
DOI : 10.1016/0092-8674(86)90004-8

M. Fenech, The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.285, issue.1, pp.35-44, 1993.
DOI : 10.1016/0027-5107(93)90049-L

M. Fenech, The in vitro micronucleus technique, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.455, issue.1-2, pp.81-95, 2000.
DOI : 10.1016/S0027-5107(00)00065-8

J. P. Ferradini, Biologie de l'action des rayonnements ionisants, 1983.

A. Fiedler, J. Skopek, T. Reinert, J. Tanner, J. Vogt et al., Irradiation experiments with living cells at LIPSION, Radiat Res, vol.161, issue.1, pp.95-96, 2004.

C. Fimognari, S. Sauer-nehls, H. Braselmann, N. A¼sse, and M. , Analysis of radiation-induced micronuclei by FISH using a combination of painting and centromeric DNA probes, Mutagenesis, vol.12, issue.2, pp.91-95, 1997.
DOI : 10.1093/mutage/12.2.91

B. Fischer, M. Heiss, and M. Cholewa, About the art to shoot with single ions. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.285-291, 2003.

M. Folkard, B. Vojnovic, K. Hollis, A. Bowey, S. Watts et al., A charged-particle microbeam: II. A single-particle micro-collimation and detection system., International Journal of Radiation Biology, vol.117, issue.4, pp.387-395, 1997.
DOI : 10.1080/095530097143167

M. Folkard, B. Vojnovic, K. M. Prise, A. G. Bowey, R. J. Locke et al., A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles, International Journal of Radiation Biology, vol.117, issue.4, pp.375-385, 1997.
DOI : 10.1080/095530097143158

D. Frankenberg, K. Greif, B. W. , and F. U. , The role of nonhomologous end joining and homologous recombination in the clonogenic bystander effects of mammalian cells after exposure to counted 10??MeV protons and 4.5??MeV ??-particles of the PTB microbeam, Radiation and Environmental Biophysics, vol.276, issue.481, pp.431-439, 2008.
DOI : 10.1007/s00411-008-0187-7

T. Funayama, S. Wada, Y. Yokota, K. Fukamoto, T. Sakashita et al., Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology, Journal of Radiation Research, vol.49, issue.1, pp.71-82, 2008.
DOI : 10.1269/jrr.07085

. Gardès-albert and A. J. Bonnefont-rousselot, Espèces réactives de l'oxygène : comment l'oxygène peut-il devenir toxique ? L'actualité chimique, 269-270, Disponible sur internet, pp.2003-2014, 2003.

H. S. Garewal, L. Ramsey, G. Kaugars, and J. Boyle, Clinical experience with the micronucleus assay, Journal of Cellular Biochemistry, vol.1, issue.S17F, pp.206-212, 1993.
DOI : 10.1002/jcb.240531031

N. Gault, O. Rigaud, J. Poncy, and J. Lefaix, Biochemical Alterations in Human Cells Irradiated with ?? Particles Delivered by Macro- or Microbeams, Radiation Research, vol.167, issue.5, pp.551-562, 2007.
DOI : 10.1667/RR0684.1

S. Gerardi, A comparative review of charged particle microbeam facilities, Radiation Protection Dosimetry, vol.122, issue.1-4, pp.285-291, 2006.
DOI : 10.1093/rpd/ncl444

S. Gerardi, G. Galeazzi, C. , and R. , Progress report on the INFN-LNL horizontal single-ion microbeam facility, Radiat Res, vol.161, issue.1, pp.93-94, 2004.

S. Gerardi, G. Galeazzi, C. , and R. , A Microcollimated Ion Beam Facility for Investigations of the Effects of Low-Dose Radiation, Radiation Research, vol.164, issue.4, pp.586-590, 2005.
DOI : 10.1667/RR3378.1

B. I. Gerashchenko and R. W. Howell, Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation, Cytometry Part A, vol.18, issue.1, pp.62-70, 2005.
DOI : 10.1002/cyto.a.20150

T. Golub, S. Wacha, C. , and P. , Spatial and temporal control of signaling through lipid rafts, Current Opinion in Neurobiology, vol.14, issue.5, pp.542-550, 2004.
DOI : 10.1016/j.conb.2004.08.003

L. H. Gray, Conditions which Affect the Biologic Damage Resulting from Exposure to Ionizing Radiation, Acta Radiologica, vol.41, issue.1, pp.63-83, 1954.
DOI : 10.3109/00016925409175836

K. Greif, H. Brede, D. Frankenberg, and U. Giesen, The PTB single ion microbeam for irradiation of living cells. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.505-512, 2004.

B. Hafer, K. Iwamoto, K. S. Schiestl, and R. H. , Refinement of the Dichlorofluorescein Assay for Flow Cytometric Measurement of Reactive Oxygen Species in Irradiated and Bystander Cell Populations, Radiation Research, vol.169, issue.4, pp.460-468, 2008.
DOI : 10.1667/RR1212.1

A. Haimovitz-friedman, C. C. Kan, D. Ehleiter, R. S. Persaud, M. Mcloughlin et al., Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis, Journal of Experimental Medicine, vol.180, issue.2, pp.525-535, 1994.
DOI : 10.1084/jem.180.2.525

E. J. Hall and A. Giaccia, Radiobiology for the radiobiologist, 2006.

E. J. Hall and T. K. Hei, Genomic instability and bystander effects induced by high-LET radiation, Oncogene, vol.22, issue.45, pp.227034-7042, 2003.
DOI : 10.1038/sj.onc.1206900

B. Halliwell and G. J. , Free Radicals in Biology and Medicine, 1999.

N. Hamada, M. Ni, T. Funayama, T. Sakashita, and Y. Kobayashi, Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.639, issue.1-2, pp.35-44, 2008.
DOI : 10.1016/j.mrfmmm.2007.11.001

M. F. Hanzal-bayer and J. F. Hancock, Lipid rafts and membrane traffic, FEBS Letters, vol.7, issue.11, pp.5812098-2104, 2007.
DOI : 10.1016/j.febslet.2007.03.019

M. Heiss, B. Fischer, and M. Cholewa, Status of the GSI microbeam facility for cell irradiation with single ions, Radiat Res, vol.161, issue.1, pp.98-99, 2004.

M. O. Hengartner, The biochemistry of apoptosis, Nature, vol.407, issue.6805, pp.770-776, 2000.
DOI : 10.1038/35037710

M. A. Hill, D. L. Stevens, M. Kadhim, M. Blake-james, A. J. Mill et al., Experimental techniques for studying bystander effects in vitro by high and low-LET ionising radiation, Radiation Protection Dosimetry, vol.122, issue.1-4, pp.1-4260, 2006.
DOI : 10.1093/rpd/ncl429

J. H. Hoeijmakers, Genome maintenance mechanisms for preventing cancer, Nature, issue.6835, pp.411366-374, 2001.

A. B. Houtsmuller, S. Rademakers, A. L. Nigg, D. Hoogstraten, J. H. Hoeijmakers et al., Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells, Science, vol.284, issue.5416, pp.284958-961, 1999.
DOI : 10.1126/science.284.5416.958

B. Hu, L. Wu, W. Han, L. Zhang, S. Chen et al., The time and spatial effects of bystander response in mammalian cells induced by low dose radiation, Carcinogenesis, vol.27, issue.2, pp.27245-251, 2006.
DOI : 10.1093/carcin/bgi224

L. Huo, H. Nagasawa, and J. B. And-little, Mutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations, Radiation Research, vol.156, issue.5, pp.521-525, 2001.
DOI : 10.1667/0033-7587(2001)156[0521:HMIIBC]2.0.CO;2

G. Iliakis, Cell cycle regulation in irradiated and nonirradiated cells, Semin Oncol, vol.24, issue.6, pp.602-615, 1997.

R. Iyer, B. E. Lehnert, and R. Svensson, Factors underlying the cell growthrelated bystander responses to alpha particles, Cancer Res, vol.60, issue.5, pp.1290-1298, 2000.

G. Joshi, W. Nelson, S. Revell, and C. Shaw, Discrimination of slow growth from non survivel among small colonies of diploid syrian hamster cells after chromosome damage induced by a range of x ray doses, Int J Radiat Biol, issue.3, pp.42283-296, 1982.

M. A. Kadhim, D. A. Macdonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden et al., Transmission of chromosomal instability after plutonium alpha-particle irradiation, Nature, issue.6362, pp.355738-740, 1992.

M. I. Kaplan, C. L. Limoli, M. , and W. F. , Perpetuating radiation-induced chromosomal instability, Radiation Oncology Investigations, vol.54, issue.3, pp.124-128, 1997.
DOI : 10.1002/(SICI)1520-6823(1997)5:3<124::AID-ROI8>3.0.CO;2-#

V. Kartsogiannis and K. Ng, Cell lines and primary cell cultures in the study of bone cell biology. Molecular and cellular endocronology, pp.79-102, 2004.

G. Kashino, K. M. Prise, G. Schettino, M. Folkard, B. Vojnovic et al., Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.556, issue.1-2, pp.209-215, 2004.
DOI : 10.1016/j.mrfmmm.2004.08.009

G. Kashino, K. M. Prise, K. Suzuki, N. Matsuda, S. Kodama et al., Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells, Journal of Radiation Research, vol.48, issue.4, pp.327-333, 2007.
DOI : 10.1269/jrr.07008

A. M. Kellerer, An algorithm for LET-analysis, Physics in Medicine and Biology, vol.17, issue.2, pp.232-240, 1972.
DOI : 10.1088/0031-9155/17/2/009

J. F. Kerr, A. H. Wyllie, and A. R. Currie, Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics, British Journal of Cancer, vol.26, issue.4, pp.239-257, 1972.
DOI : 10.1038/bjc.1972.33

K. K. Khanna and S. P. Jackson, DNA double-strand breaks : signaling, repair and the cancer connection, Nature Genetics, vol.27, issue.3, pp.247-254, 2001.
DOI : 10.1038/85798

H. Khodja, E. Berthoumieux, L. Daudin, and J. Gallien, The pierre sue laboratory nuclear microprobe as a multi-disciplinary analysis tool. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.83-86, 2001.

H. Khodja, L. Daudin, M. Hanot, J. Hoarau, M. Carriere et al., The LPS saclay single-ion microbeam facility, Radiat Res, vol.166, issue.4, pp.670-671, 2006.

Y. Kobayashi, T. Funayama, S. Wada, M. Taguchi, and H. Watanabe, Irradiation of single mammalian cells with a precise number of energetic heavy ions -applications of microbeams for studying cellular radiation response. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.308-311, 2003.

B. Konopacka, M. Rzeszowska-wolny, and J. , The bystander effect-induced formation of micronucleated cells is inhibited by antioxidants, but the parallel induction of apoptosis and loss of viability are not affected, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.593, issue.1-2, pp.32-38, 2006.
DOI : 10.1016/j.mrfmmm.2005.06.017

I. Koturbash, R. E. Rugo, C. A. Hendricks, J. Loree, B. Thibault et al., Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo, Oncogene, vol.499, issue.31, pp.254267-4275, 2006.
DOI : 10.1038/sj.onc.1209467

A. Kronenberg, Radiation-induced Genomic Instability, International Journal of Radiation Biology, vol.229, issue.5, pp.603-609, 1994.
DOI : 10.1016/0092-8674(92)90244-7

A. V. Laethem, K. Nys, S. V. Kelst, S. Claerhout, H. Ichijo et al., Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes, Free Radical Biology and Medicine, vol.41, issue.9, pp.411361-1371, 2006.
DOI : 10.1016/j.freeradbiomed.2006.07.007

P. Lau, C. E. Hellweg, and B. C. , Induction of DNA-strand breaks after xirradiation in murine bone cells of various differentiation capacities. Space Life Sciences : Aircraft and Space Radiation Environment, pp.1689-1695, 2005.

D. Lea, Actions of Radiations on Living Cells, 1962.

C. P. Lebel, H. Ischiropoulos, and S. C. Bondy, Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chemical Research in Toxicology, vol.5, issue.2, pp.227-231, 1992.
DOI : 10.1021/tx00026a012

B. E. Lehnert and E. H. Goodwin, A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny, Environmental Health Perspectives, vol.105, issue.Suppl 5, pp.1095-1101, 1997.
DOI : 10.1289/ehp.97105s51095

P. Li, Y. Zhang, Y. , and F. , Lipid Raft Redox Signaling Platforms in Endothelial Dysfunction, Antioxidants & Redox Signaling, vol.9, issue.9, pp.1457-1470, 2007.
DOI : 10.1089/ars.2007.1667

C. L. Limoli, J. J. Corcoran, R. Jordan, W. F. Morgan, and J. L. Schwartz, A role for chromosomal instability in the development of and selection for radioresistant cell variants, British Journal of Cancer, vol.84, issue.4, pp.489-492, 2001.
DOI : 10.1054/bjoc.2000.1604

J. B. Little, Radiation carcinogenesis, Carcinogenesis, vol.21, issue.3, pp.397-404, 2000.
DOI : 10.1093/carcin/21.3.397

J. B. Little, Genomic instability and bystander effects: a historical perspective, Oncogene, vol.22, issue.45, pp.6978-6987, 2003.
DOI : 10.1038/sj.onc.1206988

J. B. Little, Cellular radiation effects and the bystander response, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.597, issue.1-2, pp.113-118, 2006.
DOI : 10.1016/j.mrfmmm.2005.12.001

J. B. Little, E. I. Azzam, S. M. De-toledo, and H. Nagasawa, Bystander Effects: Intercellular Transmission of Radiation Damage Signals, Radiation Protection Dosimetry, vol.99, issue.1, pp.1-4159, 2002.
DOI : 10.1093/oxfordjournals.rpd.a006751

J. B. Little, H. Nagasawa, G. C. Li, C. , and D. J. , Involvement of the Nonhomologous End Joining DNA Repair Pathway in the Bystander Effect for Chromosomal Aberrations, Radiation Research, vol.159, issue.2, pp.262-267, 2003.
DOI : 10.1667/0033-7587(2003)159[0262:IOTNEJ]2.0.CO;2

L. A. Loeb and B. D. Preston, Mutagenesis by Apurinic/Apyrimidinic Sites, Annual Review of Genetics, vol.20, issue.1, pp.201-230, 1986.
DOI : 10.1146/annurev.ge.20.120186.001221

L. M. Loura, M. A. Castanho, A. Fedorov, and M. Prieto, A photophysical study of the polyene antibiotic filipin, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1510, issue.1-2, pp.125-135, 2001.
DOI : 10.1016/S0005-2736(00)00341-2

F. M. Lyng, P. Maguire, N. Kilmurray, C. Mothersill, C. Shao et al., Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells, International Journal of Radiation Biology, vol.98, issue.6, pp.393-399, 2006.
DOI : 10.1093/carcin/9.9.1573

F. M. Lyng, P. Maguire, B. Mcclean, C. Seymour, and C. Mothersill, The Involvement of Calcium and MAP Kinase Signaling Pathways in the Production of Radiation-Induced Bystander Effects, Radiation Research, vol.165, issue.4, pp.400-409, 2006.
DOI : 10.1667/RR3527.1

F. M. Lyng, C. B. Seymour, and C. Mothersill, Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis, British Journal of Cancer, vol.83, issue.9, pp.1223-1230, 2000.
DOI : 10.1054/bjoc.2000.1433

F. M. Lyng, C. B. Seymour, and C. Mothersill, Early Events in the Apoptotic Cascade Initiated in Cells Treated with Medium from the Progeny of Irradiated Cells, Radiation Protection Dosimetry, vol.99, issue.1, pp.1-4169, 2002.
DOI : 10.1093/oxfordjournals.rpd.a006753

F. M. Lyng, C. B. Seymour, and C. Mothersill, Initiation of Apoptosis in Cells Exposed to Medium from the Progeny of Irradiated Cells: A Possible Mechanism for Bystander-Induced Genomic Instability?, Radiation Research, vol.157, issue.4, pp.365-370, 2002.
DOI : 10.1667/0033-7587(2002)157[0365:IOAICE]2.0.CO;2

F. Marchetti, M. Coleman, I. Jones, and A. Wyrobek, Candidate protein biodosimeters of human exposure to ionizing radiation, International Journal of Radiation Biology, vol.62, issue.9, pp.605-644, 2006.
DOI : 10.1038/sj.onc.1201275

C. J. Martin, The LNT model provides the best approach for practical implementation of radiation protection, The British Journal of Radiology, vol.78, issue.925, pp.7814-7830, 2005.
DOI : 10.1259/bjr/31745335

H. Matsumoto, S. Hayashi, M. Hatashita, K. Ohnishi, H. Shioura et al., Induction of Radioresistance by a Nitric Oxide-Mediated Bystander Effect, Radiation Research, vol.155, issue.3, pp.387-396, 2001.
DOI : 10.1667/0033-7587(2001)155[0387:IORBAN]2.0.CO;2

R. H. Medema, R. Klompmaker, V. A. Smits, and G. And-rijksen, p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases, Oncogene, vol.16, issue.4, pp.431-441, 1998.
DOI : 10.1038/sj.onc.1201558

M. S. Meyn, Ataxia-telangiectasia and cellular responses to DNA damage, Cancer Res, vol.55, issue.24, pp.5991-6001, 1995.

S. Milgram, Effets cytotoxiques et phénotypiques de l'uranium et du plomb sur des modèles cellulaires ostéoblastiques. Effets cytotoxiques et phénotypiques de l'uranium et du plomb sur des modèles cellulaires ostéoblastiques, 2008.

W. Morgan and M. Sowa, Effects of ionizing radiation in nonirradiated cells, Proceedings of the National Academy of Sciences, vol.102, issue.40, pp.14127-14128, 2005.
DOI : 10.1073/pnas.0507119102

W. F. Morgan, Clastogenic Factors and Transgenerational Effects, Radiation Research, vol.159, issue.5, pp.581-596, 2003.
DOI : 10.1667/0033-7587(2003)159[0581:NADEOE]2.0.CO;2

W. F. Morgan and M. B. Sowa, Non-targeted bystander effects induced by ionizing radiation, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.616, issue.1-2, pp.159-164, 2007.
DOI : 10.1016/j.mrfmmm.2006.11.009

C. Mothersill and C. Seymour, Lethal mutations and genomic instability, Int J Radiat Biol, vol.71, issue.6, pp.751-758, 1997.

C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells, Int J Radiat Biol, vol.71, issue.4, pp.421-427, 1997.

C. Mothersill and C. Seymour, Radiation-induced bystander and other nontargeted effects : novel intervention points in cancer therapy ? Curr Cancer Drug Targets, pp.447-454, 2006.

C. Mothersill and C. B. Seymour, Actions of radiation on living cells in the ???post-bystander??? era, EXS, issue.96, pp.159-177, 2006.
DOI : 10.1007/3-7643-7378-4_7

C. Mothersill and C. B. Seymour, Radiation-induced bystander effects and the DNA paradigm: An ???out of field??? perspective, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.597, issue.1-2, pp.5-10, 2006.
DOI : 10.1016/j.mrfmmm.2005.10.011

C. Mothersill, R. J. Seymour, and C. B. Seymour, Bystander Effects in Repair-Deficient Cell Lines, Radiation Research, vol.161, issue.3, pp.256-263, 2004.
DOI : 10.1667/RR3136

J. E. Murphy, S. Nugent, C. Seymour, and C. Mothersill, Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.585, issue.1-2, pp.127-136, 2005.
DOI : 10.1016/j.mrgentox.2005.04.011

O. Myhre, J. M. Andersen, H. Aarnes, and F. Fonnum, Evaluation of the probes 2???,7???-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation, Biochemical Pharmacology, vol.65, issue.10, pp.651575-1582, 2003.
DOI : 10.1016/S0006-2952(03)00083-2

H. Nagasawa, A. Cremesti, R. Kolesnick, Z. Fuks, and J. B. And-little, Involvement of membrane signaling in the bystander effect in irradiated cells, Cancer Res, issue.9, pp.622531-2534, 2002.

H. Nagasawa, L. Huo, and J. B. And-little, Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells, International Journal of Radiation Biology, vol.79, issue.1, pp.35-41, 2003.
DOI : 10.1080/0955300021000019230

H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha-particles, Cancer Res, issue.22, pp.526394-6396, 1992.

H. Nagasawa and J. B. Little, Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect, Radiation Research, vol.152, issue.5, pp.552-557, 1999.
DOI : 10.2307/3580153

H. Nagasawa and J. B. Little, Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.508, issue.1-2, pp.121-129, 2002.
DOI : 10.1016/S0027-5107(02)00193-8

H. Nagasawa, Y. Peng, P. F. Wilson, Y. Lio, D. J. Chen et al., Role of Homologous Recombination in the Alpha-Particle-Induced Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations, Radiation Research, vol.164, issue.2, pp.141-147, 2005.
DOI : 10.1667/RR3420

H. Nagasawa, P. F. Wilson, D. J. Chen, L. H. Thompson, J. S. Bedford et al., Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination, DNA Repair, vol.7, issue.3, pp.515-522, 2008.
DOI : 10.1016/j.dnarep.2007.11.014

T. Nakano, S. Morishita, H. Terato, S. P. Pack, K. Makino et al., Repair mechanism of DNA-protein cross-link damage in Escherichia coli, Nucleic Acids Symposium Series, vol.51, issue.1, pp.213-214, 2007.
DOI : 10.1093/nass/nrm107

P. K. Narayanan, E. H. Goodwin, and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells, Cancer Res, issue.18, pp.573963-3971, 1997.

P. K. Narayanan, K. E. Larue, E. H. Goodwin, and B. E. Lehnert, Alpha Particles Induce the Production of Interleukin-8 by Human Cells, Radiation Research, vol.152, issue.1, pp.57-63, 1999.
DOI : 10.2307/3580049

H. Nikjoo, P. Oneill, M. Terrissol, and D. Goodhead, Modelling of Radiation-induced DNA Damage: The Early Physical and Chemical Event, International Journal of Radiation Biology, vol.31, issue.5, pp.453-457, 1994.
DOI : 10.1080/09553009414551451

B. Nilsson, C. Pallon, J. Thungstrom, G. Arteaga, N. Auzelyte et al., Evaluation of a pre-cell hit detector for the future single ion hit facility in lund. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.924-927, 2006.

S. M. Nugent, C. E. Mothersill, C. Seymour, B. Mcclean, F. M. Lyng et al., Increased Mitochondrial Mass in Cells with Functionally Compromised Mitochondria after Exposure to both Direct ?? Radiation and Bystander Factors, Radiation Research, vol.168, issue.1, pp.134-142, 2007.
DOI : 10.1667/RR0769.1

F. L. Page, E. E. Kwoh, A. Avrutskaya, A. Gentil, S. A. Leadon et al., Transcription-Coupled Repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome, Cell, vol.123, issue.4, pp.159-171, 2000.
DOI : 10.1016/j.cell.2005.11.005

B. Paquette and J. B. Little, In vivo enhancement of genomic instability in minisatellite sequences of mouse c3h/10t1/2 cells transformed in vitro by x-rays, Cancer Res, issue.12, pp.543173-3178, 1994.

T. T. Paull, E. P. Rogakou, V. Yamazaki, C. U. Kirchgessner, M. Gellert et al., A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage, Current Biology, vol.10, issue.15, pp.10886-895, 2000.
DOI : 10.1016/S0960-9822(00)00610-2

J. H. Petrini, The Mre11 complex and ATM: collaborating to navigate S phase, Current Opinion in Cell Biology, vol.12, issue.3, pp.293-296, 2000.
DOI : 10.1016/S0955-0674(00)00091-0

P. Pfeiffer, The mutagenic potential of DNA double-strand break repair, Toxicology Letters, vol.96, issue.1-2, pp.96-7119, 1998.
DOI : 10.1016/S0378-4274(98)00058-7

D. R. Pilch, O. A. Sedelnikova, C. Redon, A. Celeste, A. Nussenzweig et al., Characteristics of gamma-H2AX foci at DNA double-strand breaks sites, Biochem Cell Biol, issue.3, pp.81123-129, 2003.

M. Pollycove and L. Feinendegen, Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage, Human & Experimental Toxicology, vol.22, issue.6, pp.290-306, 2003.
DOI : 10.1191/0960327103ht365oa

B. Ponnaiya, G. Jenkins-baker, D. J. Brenner, E. J. Hall, G. Randers-pehrson et al., Biological Responses in Known Bystander Cells Relative to Known Microbeam-Irradiated Cells, Radiation Research, vol.162, issue.4, pp.426-432, 2004.
DOI : 10.1667/RR3236

D. I. Portess, G. Bauer, M. A. Hill, O. Neill, and P. , Low-Dose Irradiation of Nontransformed Cells Stimulates the Selective Removal of Precancerous Cells via Intercellular Induction of Apoptosis, Cancer Research, vol.67, issue.3, pp.1246-1253, 2007.
DOI : 10.1158/0008-5472.CAN-06-2985

E. L. Powers, Considerations of Survival Curves and Target Theory, Physics in Medicine and Biology, vol.7, issue.1, pp.3-28, 1962.
DOI : 10.1088/0031-9155/7/1/301

R. J. Preston, The LNT model is the best we can do???today, Journal of Radiological Protection, vol.23, issue.3, pp.263-268, 2003.
DOI : 10.1088/0952-4746/23/3/303

K. Prise, Use of Radiation Quality as a Probe for DNA Lesion Complexity, International Journal of Radiation Biology, vol.27, issue.1, pp.43-51, 1994.
DOI : 10.1080/09553009414550061

K. M. Prise, O. V. Belyakov, M. Folkard, M. , and B. D. , Studies of bystander effects in human fibroblasts using a charged particle microbeam, International Journal of Radiation Biology, vol.50, issue.6, pp.74793-798, 1998.
DOI : 10.1080/095530098141087

K. M. Prise, G. Schettino, M. Folkard, and K. D. Held, New insights on cell death from radiation exposure, The Lancet Oncology, vol.6, issue.7, pp.520-528, 2005.
DOI : 10.1016/S1470-2045(05)70246-1

M. Puck, ACTION OF X-RAYS ON MAMMALIAN CELLS, Journal of Experimental Medicine, vol.103, issue.5, pp.653-666, 1956.
DOI : 10.1084/jem.103.5.653

H. R. Ragnar, Electrostatic Accelerators : Fundamentals and Applications, 2005.

N. Ramakrishnan, D. E. Mcclain, C. , and G. N. , Membranes as Sensitive Targets in Thymocyte Apoptosis, International Journal of Radiation Biology, vol.45, issue.6, pp.693-701, 1993.
DOI : 10.1038/337181a0

G. Randers-pehrson, C. Geard, G. Johnson, C. Elliston, and D. Brenner, The Columbia University Single-Ion Microbeam, Radiation Research, vol.156, issue.2, pp.210-214, 2001.
DOI : 10.1667/0033-7587(2001)156[0210:TCUSIM]2.0.CO;2

J. C. Reed, Bcl-2 and the regulation of programmed cell death, The Journal of Cell Biology, vol.124, issue.1, pp.1-6, 1994.
DOI : 10.1083/jcb.124.1.1

P. Regulus, B. Duroux, P. Baylet, A. Favier, J. Cadet et al., Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion, Proceedings of the National Academy of Sciences, vol.104, issue.35, pp.10414032-14037, 2007.
DOI : 10.1073/pnas.0706044104

T. Reinert, A. Fiedler, J. Skopek, J. Tanner, J. Vogt et al., Single ion bombardment of living cells at LIPSION. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.219-2077, 2004.

O. Rigaud and E. Moustacchi, Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.358, issue.2, pp.127-134, 1996.
DOI : 10.1016/S0027-5107(96)00113-3

K. Rothkamm and M. Lobrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses, Proceedings of the National Academy of Sciences, vol.100, issue.9, pp.5057-5062, 2003.
DOI : 10.1073/pnas.0830918100

G. Rotman and Y. Shiloh, ATM: from gene to function, Human Molecular Genetics, vol.7, issue.10, pp.1555-1563, 1998.
DOI : 10.1093/hmg/7.10.1555

G. Rotman and Y. Shiloh, ATM: A mediator of multiple responses to genotoxic stress, Oncogene, vol.18, issue.45, pp.6135-6144, 1999.
DOI : 10.1038/sj.onc.1203124

B. Rydberg, Radiation-induced DNA Damage and Chromatin Structure, Acta Oncologica, vol.40, issue.6, pp.682-685, 2001.
DOI : 10.1080/02841860152619070

B. Sabatier, L. Lebeau, J. Dutrillaux, and B. , Chromosomal Instability and Alterations of Telomeric Repeats in Irradiated Human Fibroblasts, International Journal of Radiation Biology, vol.104, issue.8, pp.611-613, 1994.
DOI : 10.1038/355738a0

J. R. Savage, Reflections and meditations upon complex chromosomal exchanges, Mutation Research/Reviews in Mutation Research, vol.512, issue.2-3, pp.93-109, 2002.
DOI : 10.1016/S1383-5742(02)00066-2

G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, K. D. Held et al., Low-Dose Studies of Bystander Cell Killing with Targeted Soft X Rays, Radiation Research, vol.160, issue.5, pp.505-511, 2003.
DOI : 10.1667/RR3060

P. C. Schiller, G. Ippolito, W. Balkan, B. A. Roos, H. et al., Gap-junctional communication is required for the maturation process of osteoblastic cells in culture, Bone, vol.28, issue.4, pp.362-369, 2001.
DOI : 10.1016/S8756-3282(00)00458-0

O. A. Sedelnikova, A. Nakamura, O. Kovalchuk, I. Koturbash, S. A. Mitchell et al., DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models, Cancer Research, vol.67, issue.9, pp.4295-4302, 2007.
DOI : 10.1158/0008-5472.CAN-06-4442

P. Sengupta, B. Baird, and D. Holowka, Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function, Seminars in Cell & Developmental Biology, vol.18, issue.5, pp.583-590, 2007.
DOI : 10.1016/j.semcdb.2007.07.010

C. Seymour and C. Mothersill, Cell Communication and the "Bystander Effect", Radiation Research, vol.151, issue.4, pp.505-506, 1999.
DOI : 10.2307/3579842

C. Shao, M. Folkard, B. D. Michael, and K. M. Prise, Targeted cytoplasmic irradiation induces bystander responses, Proceedings of the National Academy of Sciences, vol.101, issue.37, pp.13495-13500, 2004.
DOI : 10.1073/pnas.0404930101
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518785

C. Shao, M. Folkard, and K. M. Prise, Role of TGF-??1 and nitric oxide in the bystander response of irradiated glioma cells, Oncogene, vol.59, issue.4, pp.434-440, 2008.
DOI : 10.1073/pnas.030420797

C. Shao, Y. Furusawa, M. Aoki, and K. Ando, Role of Gap Junctional Intercellular Communication in Radiation-Induced Bystander Effects in Human Fibroblasts, Radiation Research, vol.160, issue.3, pp.318-323, 2003.
DOI : 10.1667/RR3044

C. Shao, Y. Furusawa, M. Aoki, H. Matsumoto, and K. Ando, Nitric oxidemediated bystander effect induced by heavy-ions in human salivary gland tumour cells, 2002.

C. Shao, Y. Furusawa, Y. Kobayashi, and T. Funayama, Involvement of gap junctional intercellular communication in the bystander effect induced by broad-beam or microbeam heavy ions. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.177-181, 2006.

C. Shao, Y. Furusawa, Y. Kobayashi, T. Funayama, and S. Wada, Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study, The FASEB Journal, vol.17, issue.11, pp.171422-1427, 2003.
DOI : 10.1096/fj.02-1115com

C. Shao, F. M. Lyng, M. Folkard, and K. M. Prise, Calcium Fluxes Modulate the Radiation-Induced Bystander Responses in Targeted Glioma and Fibroblast Cells, Radiation Research, vol.166, issue.3, pp.479-487, 2006.
DOI : 10.1667/RR3600.1

C. Shao, K. M. Prise, and M. Folkard, Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.638, issue.1-2, pp.139-145, 2008.
DOI : 10.1016/j.mrfmmm.2007.09.007

C. Shao, V. Stewart, M. Folkard, B. D. Michael, and K. M. Prise, Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells, Cancer Res, issue.23, pp.638437-8442, 2003.

D. Shao, A. W. Segal, and L. V. Dekker, Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils, FEBS Letters, vol.357, issue.1-3, pp.1-3101, 2003.
DOI : 10.1016/S0014-5793(03)00845-7

A. Shariff, V. Auzelyte, M. Elfman, P. Kristiansson, K. Malmqvist et al., The lund nuclear microprobe sub-micron set-up. part i : Ion optics calculation. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.2311-2317, 2005.

A. Shariff, C. Nilsson, V. Auzelyte, M. Elfman, P. Kristiansson et al., The lund nuclear microprobe sub-micron set-up. part ii : Beam line, focusing system and scanning. Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.2317-2330, 2005.

K. Simons and E. Ikonen, Functional rafts in cell membranes, Nature, vol.387, issue.6633, pp.569-572, 1997.
DOI : 10.1038/42408

W. Sinclair, X-Ray-Induced Heritable Damage (Small-Colony Formation) in Cultured Mammalian Cells, Radiation Research, vol.21, issue.4, pp.584-90, 1964.
DOI : 10.2307/3571653

R. P. Sinha and D. P. Heder, UV-induced DNA damage and repair: a review, Photochemical & Photobiological Sciences, vol.1, issue.4, pp.225-236, 2002.
DOI : 10.1039/b201230h

M. V. Sokolov, L. B. Smilenov, E. J. Hall, I. G. Panyutin, W. M. Bonner et al., Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts, Oncogene, vol.97, issue.49, pp.247257-7265, 2005.
DOI : 10.1038/sj.onc.1208886

Z. Somosy, Radiation response of cell organelles, Micron, vol.31, issue.2, pp.165-181, 2000.
DOI : 10.1016/S0968-4328(99)00083-9

L. Stojic, R. Brun, and J. Jiricny, Mismatch repair and DNA damage signalling, DNA Repair, vol.3, issue.8-9, pp.8-91091, 2004.
DOI : 10.1016/j.dnarep.2004.06.006

K. Sugasawa, T. Okamoto, Y. Shimizu, C. Masutani, S. Iwai et al., A multistep damage recognition mechanism for global genomic nucleotide excision repair, Genes & Development, vol.15, issue.5, pp.507-521, 2001.
DOI : 10.1101/gad.866301

S. A. Bibliographie-susin, N. Zamzami, M. Castedo, E. Daugas, H. G. Wang et al., The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis, The Journal of Experimental Medicine, vol.153, issue.1, pp.25-37, 1997.
DOI : 10.1074/jbc.272.5.2952

M. Suzuki, H. Zhou, C. R. Geard, and T. K. Hei, Effect of Medium on Chromatin Damage in Bystander Mammalian Cells, Radiation Research, vol.162, issue.3, pp.264-269, 2004.
DOI : 10.1667/RR3226

I. Szumiel, The bystander effect : is reactive oxygen species the driver ?, Nukleonika, vol.48, issue.3, pp.113-120, 2003.

I. Szumiel, M. Kapiszewska, M. Kruszewski, T. Iwanenko, and C. S. Lange, Content of iron and copper in the nuclei and induction of pH 9-labile lesions in L5178Y sublines inversely cross-sensitive to H2O2 and x-rays, Radiation and Environmental Biophysics, vol.112, issue.Suppl VIII, pp.113-119, 1995.
DOI : 10.1007/BF01275216

S. Tapio and V. Jacob, Radioadaptive response revisited, Radiation and Environmental Biophysics, vol.94, issue.Suppl, pp.1-12, 2007.
DOI : 10.1007/s00411-006-0078-8

L. Tartier, S. Gilchrist, S. Burdak-rothkamm, M. Folkard, and K. M. Prise, Cytoplasmic Irradiation Induces Mitochondrial-Dependent 53BP1 Protein Relocalization in Irradiated and Bystander Cells, Cancer Research, vol.67, issue.12, pp.675872-5879, 2007.
DOI : 10.1158/0008-5472.CAN-07-0188

F. Teyssier, J. Bay, and D. C. , Cell cycle regulation after exposure to ionizing radiation, Bull Cancer, vol.86, issue.4, pp.345-57, 1999.

V. J. Thannickal, K. D. Aldweib, and B. L. Fanburg, Tyrosine phosphorylation regulates H2O2 production in lung fibroblasts stimulated by transforming growth factor beta1, J Biol Chem, issue.36, pp.27323611-23615, 1998.

V. J. Thannickal, R. M. Day, S. G. Klinz, M. C. Bastien, J. M. Larios et al., Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-beta1, The FASEB Journal, vol.14, issue.12, pp.141741-1748, 2000.
DOI : 10.1096/fj.99-0878com

V. J. Thannickal and B. L. Fanburg, Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor ??1, Journal of Biological Chemistry, vol.270, issue.51, pp.30334-30338, 1995.
DOI : 10.1074/jbc.270.51.30334

Z. Timofeeff-ressovsky, Das Trefferprinzip in der Biologie, 1947.

P. Todd, Defective mammalian cells isolated from X-irradiated cultures, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.5, issue.1, pp.173-78, 1968.
DOI : 10.1016/0027-5107(68)90090-0

S. Tomizawa, H. Imai, S. Tsukada, T. Simizu, F. Honda et al., The detection and quantification of highly reactive oxygen species using the novel HPF fluorescence probe in a rat model of focal cerebral ischemia, Neuroscience Research, vol.53, issue.3, pp.304-313, 2005.
DOI : 10.1016/j.neures.2005.08.002

R. B. Uretz, W. Bloom, and R. E. Zirkle, Irradiation of Parts of Individual Cells II. Effects of an Ultraviolet Microbeam Focused on Parts of Chromosomes, Science, vol.120, issue.3110, pp.120197-199, 1954.
DOI : 10.1126/science.120.3110.197

K. Valerie, A. Yacoub, M. P. Hagan, D. T. Curiel, P. B. Fisher et al., Radiation-induced cell signaling: inside-out and outside-in, Molecular Cancer Therapeutics, vol.6, issue.3, 2007.
DOI : 10.1158/1535-7163.MCT-06-0596

M. Verheij, G. A. Ruiter, S. F. Zerp, W. J. Van-blitterswijk, Z. Fuks et al., The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis, Radiotherapy and Oncology, vol.47, issue.3, pp.47225-232, 1998.
DOI : 10.1016/S0167-8140(98)00007-3

O. Veselov, J. Lekki, W. Polak, D. Strivay, Z. Stachura et al., The recognition of biological cells utilizing quantitative phase microscopy system . Nuclear instruments and methods in physics research section B -Beam interactions with materials ans atoms, pp.231212-217, 2005.

O. Veselov, W. Polak, R. Ugenskiene, K. Lebed, J. Lekki et al., Development of the IFJ single ion hit facility for cell irradiation, Radiation Protection Dosimetry, vol.122, issue.1-4, pp.1-4316, 2006.
DOI : 10.1093/rpd/ncl437

D. Wang, K. Christensen, K. Chawla, G. Xiao, P. H. Krebsbach et al., Isolation and Characterization of MC3T3-E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential, Journal of Bone and Mineral Research, vol.17, issue.Suppl, pp.14893-903, 1999.
DOI : 10.1359/jbmr.1999.14.6.893

D. Wang, D. A. Kreutzer, and J. M. And-essigmann, Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.400, issue.1-2, pp.99-115, 1998.
DOI : 10.1016/S0027-5107(98)00066-9

X. Wang and A. S. Paller, Lipid Rafts: Membrane Triage Centers, Journal of Investigative Dermatology, vol.126, issue.5, pp.951-953, 2006.
DOI : 10.1038/sj.jid.5700282
URL : http://doi.org/10.1038/sj.jid.5700282

J. F. Ward, Nature of lesions formed by ionizing radiation., volume II, DNA Damage and Repair : Biochemistry, Genetics, and Cell Biology, 1997.

G. E. Watson, S. A. Lorimore, S. M. Clutton, M. A. Kadhim, W. et al., Genetic factors influencing alpha-particle-induced chromosomal instability, Int J Radiat Biol, issue.5, pp.71497-503, 1997.

C. J. Whitehouse, R. M. Taylor, A. Thistlethwaite, H. Zhang, F. Karimi-busheri et al., XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair, Cell, vol.104, issue.1, pp.107-117, 2001.
DOI : 10.1016/S0092-8674(01)00195-7

E. G. Wright, Radiation-induced genomic instability in haemopoietic cells, International Journal of Radiation Biology, vol.74, issue.6, pp.681-687, 1998.
DOI : 10.1080/095530098140943

E. G. Wright, Inherited and inducible chromosomal instability: a fragile bridge between genome integrity mechanisms and tumourigenesis, The Journal of Pathology, vol.76, issue.1, pp.19-27, 1999.
DOI : 10.1002/(SICI)1096-9896(199901)187:1<19::AID-PATH233>3.0.CO;2-1

L. J. Wu, G. Randers-pehrson, A. Xu, C. A. Waldren, C. R. Geard et al., Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells, Proceedings of the National Academy of Sciences, vol.96, issue.9, pp.964959-4964, 1999.
DOI : 10.1073/pnas.96.9.4959

H. Yang, N. Asaad, and K. D. Held, Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts, Oncogene, vol.24, issue.12, pp.242096-2103, 2005.
DOI : 10.1038/sj.onc.1208439

L. S. Yasui, K. Chen, K. Wang, T. P. Jones, J. Caldwell et al., Using Hoechst 33342 to Target Radioactivity to the Cell Nucleus, Radiation Research, vol.167, issue.2, pp.167-175, 2007.
DOI : 10.1667/RR0584.1

Q. Zhan, F. Carrier, and A. J. Fornace, Induction of cellular p53 activity by DNA-damaging agents and growth arrest., Molecular and Cellular Biology, vol.13, issue.7, pp.4242-4250, 1993.
DOI : 10.1128/MCB.13.7.4242

B. B. Zhou and S. J. Elledge, The DNA damage response : putting checkpoints in perspective, Nature, issue.6811, pp.408433-439, 2000.

H. Zhou, V. N. Ivanov, Y. Lien, M. Davidson, and T. K. Hei, Mitochondrial function and nuclear factor-kappab-mediated signaling in radiation-induced bystander effects, Cancer Res, issue.7, pp.682233-2240, 2008.

H. Zhou, G. Randers-pehrson, C. A. Waldren, D. Vannais, E. J. Hall et al., Induction of a bystander mutagenic effect of alpha particles in mammalian cells, Proceedings of the National Academy of Sciences, vol.97, issue.5, pp.972099-2104, 2000.
DOI : 10.1073/pnas.030420797

H. Zhou, M. Suzuki, J. Gillispie, G. Randers-pehrson, and T. K. Hei, Cytoplasmic radiation-induced bystander mutagenesis, Radiat Res, vol.166, issue.4, p.689, 2006.

H. Zhou, M. Suzuki, G. Randers-pehrson, D. Vannais, G. Chen et al., Radiation risk to low fluences of alpha particles may be greater than we thought, Proc Natl Acad Sci, issue.25, pp.9814410-14415, 2001.

R. E. Zirkle and W. Bloom, Irradiation of Parts of Individual Cells, Science, vol.117, issue.3045, pp.487-493, 1953.
DOI : 10.1126/science.117.3045.487