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Synthèse d'un podocarpane fonctionnalisé et préparation d'hétéroquinones pour l'inhibition de phosphatases et de réductases

Abstract : The main subject of this presented thesis deals with the synthesis of new quinones, especially terpenylquinones and heteroquinones, compounds that are known to have interesting biologycal properties. The first part concerns the preparation of a functionalized podocarpane, a key intermediate in the synthesis of natural compounds like celaphanol A. The second part deals with the preparation of heteroquinones and it is divided in two subparts: the synthesis of thioalkylated heteroquinones and the preparation of heteroquinones with antimalarial activity. The thioalkylated compounds were tested as potential anticancer drugs (inhibition of CDC25 phosphatases) and the evaluation of the biological activity of the antimalarial quinones allowed the identification of a key compound that was coupled with a terpenic derivative.
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https://tel.archives-ouvertes.fr/tel-00426773
Contributor : Tatiana Besset <>
Submitted on : Tuesday, October 27, 2009 - 5:48:35 PM
Last modification on : Friday, November 6, 2020 - 4:03:14 AM
Long-term archiving on: : Thursday, June 17, 2010 - 6:24:31 PM

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  • HAL Id : tel-00426773, version 1

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Tatiana Besset. Synthèse d'un podocarpane fonctionnalisé et préparation d'hétéroquinones pour l'inhibition de phosphatases et de réductases. Chimie. Université Joseph-Fourier - Grenoble I, 2009. Français. ⟨tel-00426773⟩

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