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Nouveaux mécanismes de régulation de la concentration calcique réticulaire : implication dans la physiopathologie de la prostate humaine.

Abstract : Prostate cancer is the second cancer-related cause of decease. Nowadays, treatments aim at decreasing the androgen action on this organ. Unfortunately, with time, patients develop an androgen-independent cancer with fatal issue. Calcium (Ca2+), an ubiquitary second messenger, is involved in several processes such as apoptosis and proliferation. Endoplasmic Reticulum (ER) is a major actor in Ca2+ signalling. Thus, the study of ER channels is critical for developing new therapeutic strategies. Our work led to the identification of two new ER proteins: the translocon and TRPM8 channel (Transient Receptor Potential Melastatin 8). These two channels could represent fundamental elements of calcium signalisation by regulating Ca2+ concentration in the ER. Moreover, the study of Ca2+ signature evolution during prostate carcinogenesis led us to show that Orai1 (identified here as the main carrier of capacitative Ca2+ entry) expression is decreased in advanced prostate cancer. Reversely, TRPV6 (Transient Receptor Potential Vanilloid 6), a Ca2+ channel involved in constitutive Ca2+ entry, is over expressed in prostate cancer later stages. Thus, variations in these proteins expression could be responsible respectively for apoptosis resistance or an increase in prostate cancer cells proliferation. This might explain the evolution of prostate cancer to more aggressive stages.
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Contributor : Matthieu Flourakis <>
Submitted on : Tuesday, July 7, 2009 - 6:28:15 PM
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Matthieu Flourakis. Nouveaux mécanismes de régulation de la concentration calcique réticulaire : implication dans la physiopathologie de la prostate humaine.. Biologie cellulaire. Université des Sciences et Technologie de Lille - Lille I, 2007. Français. ⟨tel-00402635⟩

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