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Contrôle de température et étude des transferts thermiques dans des dispositifs microfluidiques

Abstract : The purpose of this work is to study microfluidic devices with integrated thermal elements for process temperature monitoring and controlling. The ability of multiple parameters controlling, the small time-constant of micro-scale heat transfer, and the possibility of large scale device integration allow us to propose new tools for other advanced research purposes. In physics, we fabricated micro-conductimeters as tool to study thermal conductivity of nanofluids. In chemistry, we developed a flow-in micro-calorimeter which is compatible to the common lab-on-chip technologies. The possibility given by the high speed of heat transfer in microfluidic device led to the development of new tools for cell biology. In particular, we have being able to confine a colony of yeast cell and change the working temperature in a few seconds. It allowed us to control thermo sensitive protein activity and studying cytoskeleton properties of S.Pombe yeast. The devices and methods we proposed are therefore pertinent, providing new tools for cell biology studies and allowing in particularly a better understanding of the role of thermo sensitive proteins.
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https://tel.archives-ouvertes.fr/tel-00391813
Contributor : Guilhem Velve Casquillas <>
Submitted on : Thursday, June 4, 2009 - 5:48:14 PM
Last modification on : Friday, July 3, 2020 - 9:28:03 AM
Long-term archiving on: : Friday, June 11, 2010 - 12:21:12 AM

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  • HAL Id : tel-00391813, version 1

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Guilhem Velve-Casquillas. Contrôle de température et étude des transferts thermiques dans des dispositifs microfluidiques. Physique [physics]. Université Paris Sud - Paris XI, 2008. Français. ⟨tel-00391813⟩

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