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Caractérisation des lymphocytes T CD8+ générés en conditions inflammatoires stériles

Abstract : Most memory CD8 T cell subsets that have been defined are generated during viral infection. The aim of this work was to characterize a memory cell subset generated in sterile inflammatory conditions, i.e. in the absence of pathogen-derived signals. Those memory cells are characterized by their surface expression level of CD44/CD122, which are intermediate between those of naïve and pathogen-induced memory CD8 T cells. The memory cells from the sterile inflammation-induced subset also express intermediate levels of several other memory traits, including functional (IFN-g secretion capacity) and molecular (T-bet and Eomes) features. They correspond to an early differentiation stage and can further differentiate in conventional central memory T cells. This work made it possible to characterize the various properties of the cells memories generated in a sterile inflammatory context and especially the implication of these cells in skin inflammatory diseases like allergic contact dermatis
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Contributor : Florentin Martial Mbitikon-Kobo <>
Submitted on : Wednesday, May 27, 2009 - 11:23:35 PM
Last modification on : Thursday, November 21, 2019 - 2:25:18 AM
Long-term archiving on: : Thursday, June 10, 2010 - 7:44:02 PM


  • HAL Id : tel-00389013, version 1



Florentin Martial Mbitikon-Kobo. Caractérisation des lymphocytes T CD8+ générés en conditions inflammatoires stériles. Immunologie. Ecole normale supérieure de lyon - ENS LYON, 2009. Français. ⟨tel-00389013⟩



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