Skip to Main content Skip to Navigation
Theses

Evaluations physico-chimiques et biologiques de polyéthylène téréphthalate (PET) après traitement de surface par irradiations LASER en vue d'applications biomédicales

Abstract : The remarkable improvements made in the field of biomaterials lead clinicians to propose to patients the profit of replacement of damaged organs. Unfortunately, some complications may occur after implantation if these materials are used in their native form. That is the case of PET vascular grafts which are currently used because of their good mechanical properties, but which can generate tragic consequences for the patients when they replace very small vessels. However, it is henceforth possible to improve one or more of their properties through different methods of surface functionalization. That is the aim of our work, by using different LASER beams to irradiate PET-film samples in order to study physico-chemical and biological modifications generated by these means on the material surface.
First, we tested different PET types with the aim to select the most adapted PET-film to simulate vascular prostheses � what had never been done up to date. Results are explicit and prove the importance of the choice of a PET material for further intensives investigations. Our work clearly leads us to consider preferentially the PET-film Melinex® (DuPont Teijin FilmsTM).
The second part of this study allowed us to test different LASER beams in order to select the most performing one with respect to cell behaviour improvement. Undoubtedly, excimer LASER used at 248 nm wavelength is the best LASER to improve cell proliferation, cell vitality and cell adhesion, without any damage on cell morphology. These positive results are explained by physico-chemical modifications that occurred on the irradiated PET surface: evolution in roughness, in surface tension and in surface chemistry. Such encouraging results may allow us to transform the simple implantable PET material to a real biomaterial with strongly accepted performances.
Keywords: Polyethylene terephthalate, Excimer LASER, YAG LASER, surface analysis, cytocompatibility, cell adhesion
Document type :
Theses
Complete list of metadatas

Cited literature [85 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00381301
Contributor : Grégoire Mayer <>
Submitted on : Tuesday, May 5, 2009 - 4:32:30 PM
Last modification on : Thursday, February 21, 2019 - 9:56:03 AM
Long-term archiving on: : Thursday, June 10, 2010 - 8:55:30 PM

Identifiers

  • HAL Id : tel-00381301, version 1

Citation

Grégoire Mayer. Evaluations physico-chimiques et biologiques de polyéthylène téréphthalate (PET) après traitement de surface par irradiations LASER en vue d'applications biomédicales. Sciences du Vivant [q-bio]. Université du Droit et de la Santé - Lille II, 2007. Français. ⟨tel-00381301⟩

Share

Metrics

Record views

299

Files downloads

5523