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L'effet du vieillissement sur la microcirculation cutanée

Abstract : The pressure application on the skin leads to an increase of the cutaneous blood flow, called pressure-induced vasodilatation (PIV), that delays the occurrence of tissue ischemia resulting from this pressure. The development of this PIV depends on the activation by pressure of sensory C-fibres, leading to the release of neurotransmitters that acts at the endothelium level to stimulate the synthesis and release of endothelial factors inducing smooth muscle relaxation. This work had for objective to study the modifications of the PIV with the ageing. In old mice, without peripheral neuropathy, the PIV was reduced because of a decrease of the endothelium-dependent vasodilatation and the endothelium factors of the vasodilatation were redistributed with a contribution of Endothelium-Derived Hyperpolarizing Factor because of a decrease of the nitric oxide and the prostacyclin. In old subjects (60-75 years), the PIV was altered in comparison with young subjects (20-35 years) because of a decrease of the endothelium-dependent vasodilatation and a sensory fibres and/or neuromediators alteration. In the presence of a peripheral neuropathy, the PIV was abolished. These modifications of the cutaneous microcirculation with the ageing would lead to an early occurrence of ischemia related to an increased risk for pressure ulcers and the understanding of PIV modifications allow to glimpse of news perceptives of prevention and treatment of pressure ulcers in elderly
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Submitted on : Tuesday, March 24, 2009 - 1:25:37 PM
Last modification on : Friday, October 23, 2020 - 4:35:35 PM
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  • HAL Id : tel-00370422, version 1

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Marie-Line Dahan (ép. Gaubert). L'effet du vieillissement sur la microcirculation cutanée. Physiologie [q-bio.TO]. Université Claude Bernard - Lyon I, 2008. Français. ⟨tel-00370422⟩

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