R. 1. Rothenberg, M. E. , and S. P. Hogan, THE EOSINOPHIL, Annual Review of Immunology, vol.24, issue.1, pp.147-174, 2006.
DOI : 10.1146/annurev.immunol.24.021605.090720

E. A. Jacobsen, S. I. Ochkur, R. S. Pero, A. G. Taranova, C. A. Protheroe et al., Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells, The Journal of Experimental Medicine, vol.280, issue.3, pp.699-710, 2008.
DOI : 10.4049/jimmunol.173.7.4692

M. Kinet and . Capron, High-affinity IgE receptor on eosinophils is involved in defence against parasites, Nature, vol.367, pp.183-186, 1994.

A. L. Stenfeldt and C. Wenneras, Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils, Immunology, vol.171, issue.4, pp.605-614, 2004.
DOI : 10.1182/blood.V97.1.235
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782530

E. A. Jacobsen, A. G. Taranova, N. A. Lee, and J. J. Lee, Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?, Journal of Allergy and Clinical Immunology, vol.119, issue.6, pp.1313-1320, 2007.
DOI : 10.1016/j.jaci.2007.03.043

R. I. Tepper, R. L. Coffman, and P. Leder, An eosinophil-dependent mechanism for the antitumor effect of interleukin-4, Science, vol.257, issue.5069, pp.548-551, 1992.
DOI : 10.1126/science.1636093

G. Woerly, N. Roger, S. Loiseau, D. Dombrowicz, A. Capron et al., Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon ??), The Journal of Experimental Medicine, vol.18, issue.4, pp.487-495, 1999.
DOI : 10.1084/jem.177.3.845

H. M. Algood, P. L. Lin, and J. L. Flynn, Tumor Necrosis Factor and Chemokine Interactions in the Formation and Maintenance of Granulomas in Tuberculosis, Clinical Infectious Diseases, vol.41, issue.Supplement 3, pp.189-93, 2005.
DOI : 10.1086/429994

F. Altare, D. Lammas, P. Revy, E. Jouanguy, R. Doffinger et al., Inherited interleukin 12 deficiency in a child with bacille Calmette-Gu??rin and Salmonella enteritidis disseminated infection., Journal of Clinical Investigation, vol.102, issue.12, pp.2035-2075, 1998.
DOI : 10.1172/JCI4950

J. Maaskant, N. G. Stoker, P. Van-der-ley, G. Puzo, C. M. Vandenbroucke-grauls et al., The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction, Cell Microbiol, vol.10, issue.4, pp.930-974, 2008.

M. Wittke, A. M. Rollinghoff, S. A. Krensky, R. L. Porcelli, S. Modlin et al., Human NKT cells express granulysin and exhibit antimycobacterial activity, J Immunol, vol.170, issue.6, pp.3154-61, 2003.

A. Garg, P. F. Barnes, S. Roy, M. F. Quiroga, S. Wu et al., Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in humanMycobacterium tuberculosisinfection, European Journal of Immunology, vol.69, issue.2, pp.459-69, 2008.
DOI : 10.1002/eji.200737268

C. D. Gaynor, F. X. Mccormack, D. R. Voelker, S. E. Mcgowan, and L. S. Schlesinger, Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages, J Immunol, vol.155, issue.11, pp.5343-51, 1995.

A. J. Gehring, K. M. Dobos, J. T. Belisle, C. V. Harding, and W. H. Boom, Mycobacterium tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing, The Journal of Immunology, vol.173, issue.4, pp.2660-2668, 2004.
DOI : 10.4049/jimmunol.173.4.2660

I. Akira, A. Azuma, K. Hayashi, T. Toyoshima, and . Seya, Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus, 2000.

. Orme, Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis, Infect Immun, vol.71, issue.2, pp.864-71, 2003.

C. C. Tydell, N. Yount, D. Tran, J. Yuan, and M. E. Selsted, Isolation, Characterization, and Antimicrobial Properties of Bovine Oligosaccharide-binding Protein. A MICROBICIDAL GRANULE PROTEIN OF EOSINOPHILS AND NEUTROPHILS, Journal of Biological Chemistry, vol.277, issue.22, pp.19658-64, 2002.
DOI : 10.1074/jbc.M200659200

H. Tsutsui, G. Shimokawa, J. J. Bellon, M. Lee, G. Przybylski et al., Posttranslational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase, J Biol Chem, vol.283, issue.42, pp.28629-28640, 2008.

D. M. Underhill, A. Ozinsky, K. D. Smith, and A. Aderem, Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages, Proceedings of the National Academy of Sciences, vol.96, issue.25, pp.96-14459, 1999.
DOI : 10.1073/pnas.96.25.14459

T. Urasaki, J. Takasaki, T. Nagasawa, and H. Ninomiya, Pivotal role of 5- lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway, J Leukoc Biol, vol.69, issue.1, pp.105-117, 2001.

V. Van-der-bruggen, T. , P. T. Kok, J. A. Raaijmakers, J. W. Lammers et al., Cooperation between Fc gamma receptor II and complement receptor type 3 during activation of plateletactivating factor release by cytokine-primed human eosinophils, J Immunol, vol.153, issue.6, pp.2729-2764, 1994.

L. S. Van-rijt, N. Vos, D. Hijdra, V. C. De-vries, H. C. Hoogsteden et al., Airway Eosinophils Accumulate in the Mediastinal Lymph Nodes but Lack Antigen-Presenting Potential for Naive T Cells, The Journal of Immunology, vol.171, issue.7, pp.3372-3380, 2003.
DOI : 10.4049/jimmunol.171.7.3372

L. L. Veinotte, T. Y. Halim, and F. Takei, Unique subset of natural killer cells develops from progenitors in lymph node, Blood, vol.111, issue.8, pp.4201-4209, 2008.
DOI : 10.1182/blood-2007-04-087577

M. A. Velasco-velazquez, D. Barrera, A. Gonzalez-arenas, C. Rosales, and J. Agramonte-hevia, Macrophage???Mycobacterium tuberculosis interactions: role of complement receptor 3, Microbial Pathogenesis, vol.35, issue.3, pp.125-156, 2003.
DOI : 10.1016/S0882-4010(03)00099-8

P. Venge, J. Bystrom, M. Carlson, L. Hakansson, M. Karawacjzyk et al., Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.73, issue.6, pp.1172-86, 1999.
DOI : 10.1016/0022-1759(93)90359-F

V. K. Vijayan, A. M. Reetha, M. S. Jawahar, K. Sankaran, and R. Prabhakar, Pulmonary Eosinophilia in Pulmonary Tuberculosis, Chest, vol.101, issue.6, pp.1708-1717, 1992.
DOI : 10.1378/chest.101.6.1708

C. Villeneuve, G. Etienne, V. Abadie, H. Montrozier, C. Bordier et al., Surface-exposed Glycopeptidolipids of Mycobacterium smegmatis Specifically Inhibit the Phagocytosis of Mycobacteria by Human Macrophages: IDENTIFICATION OF A NOVEL FAMILY OF GLYCOPEPTIDOLIPIDS, Journal of Biological Chemistry, vol.278, issue.51, pp.51291-300, 2003.
DOI : 10.1074/jbc.M306554200

F. De-vos, K. Takeda, S. Akira, D. T. Golenbock, A. Verbon et al., Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2, Am J Respir Crit Care Med, vol.170, issue.12, pp.1367-74, 2004.

T. Wileman, G. R. Carson, M. Concino, A. Ahmed, and C. Terhorst, The gamma and epsilon subunits of the CD3 complex inhibit pre-Golgi degradation of newly synthesized T cell antigen receptors, The Journal of Cell Biology, vol.110, issue.4, pp.973-86, 1990.
DOI : 10.1083/jcb.110.4.973

. Schaible, Saposin C is required for lipid presentation by human CD1b, Nat Immunol, vol.5, issue.2, pp.169-74, 2004.

G. Woerly, N. Roger, S. Loiseau, D. Dombrowicz, A. Capron et al., Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon transduction in the absence of serum, Infect Immun, vol.66, issue.9, pp.4541-4545, 1999.

J. Zhang, L. J. Lathbury, and L. A. Salamonsen, Expression of the Chemokine Eotaxin and Its Receptor, CCR3, in Human Endometrium1, Biology of Reproduction, vol.62, issue.2, pp.404-415, 2000.
DOI : 10.1095/biolreprod62.2.404

Y. Zhang, Y. Song, F. Yin, E. Broderick, K. Siegel et al., Structural Studies of V??2V??2 T Cell Phosphoantigens, Chemistry & Biology, vol.13, issue.9, pp.985-92, 2006.
DOI : 10.1016/j.chembiol.2006.08.007

S. Zimmerli, S. Edwards, and J. D. Ernst, Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages., American Journal of Respiratory Cell and Molecular Biology, vol.15, issue.6, pp.760-70, 1996.
DOI : 10.1165/ajrcmb.15.6.8969271

K. L. Asquith, H. S. Ramshaw, P. M. Hansbro, K. W. Beagley, A. F. Lopez et al., The IL-3/IL-5/GM-CSF Common ?? Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation, The Journal of Immunology, vol.180, issue.2, pp.180-1199, 2008.
DOI : 10.4049/jimmunol.180.2.1199

M. E. Rothenberg and S. P. Hogan, THE EOSINOPHIL, Annual Review of Immunology, vol.24, issue.1, pp.147-74, 2006.
DOI : 10.1146/annurev.immunol.24.021605.090720

G. Woerly, P. Lacy, A. B. Younes, N. Roger, S. Loiseau et al., Human eosinophils express and release IL-13 following CD28-dependent activation, J Leukoc Biol, issue.4, pp.72-769, 2002.

R. J. Basaraba, E. E. Smith, C. A. Shanley, and I. M. Orme, Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by Aerosol, Infection and Immunity, vol.74, issue.9, pp.74-5397, 2006.
DOI : 10.1128/IAI.00332-06

D. Avila, H. Almeida, P. E. Roque, N. R. Castro-faria-neto, H. C. Bozza et al., Toll-like receptor-2- mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy, Infect Immun, issue.3, pp.75-1507, 2007.

F. Legrand, G. Woerly, V. Driss, and M. Capron, Innate Immune Function of Eosinophils, Methods Mol Biol, issue.415, pp.215-255, 2008.
DOI : 10.1007/978-1-59745-570-1_13

Y. C. Su, M. S. Rolph, N. G. Hansbro, C. R. Mackay, and W. A. Sewell, Granulocyte-Macrophage Colony-Stimulating Factor Is Required for Bronchial Eosinophilia in a Murine Model of Allergic Airway Inflammation, The Journal of Immunology, vol.180, issue.4, pp.2600-2607, 2008.
DOI : 10.4049/jimmunol.180.4.2600

M. Kumar, A. K. Behera, H. Matsuse, R. F. Lockey, S. S. Mohapatra et al., A recombinant BCG vaccine generates a Th1-like response and inhibits IgE synthesis in BALB/c mice Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. IL-4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils, Immunology J Immunol, vol.97, issue.36, pp.515-536, 1995.

N. W. Schroder and M. Arditi, The role of innate immunity in the pathogenesis of asthma, Current Opinion in Allergy and Clinical Immunology, vol.9, issue.1, pp.305-317, 2007.
DOI : 10.1097/ACI.0b013e32831d0f99

I. B. Barlan, N. Bahceciler, M. Akdis, and C. A. Akdis, Role of bacillus Calmette???Gu??rin as an immunomodulator for the prevention and treatment of allergy and asthma, Current Opinion in Allergy and Clinical Immunology, vol.5, issue.6, pp.552-559, 2005.
DOI : 10.1097/01.all.0000191238.20632.e2

H. Nagase, S. Okugawa, Y. Ota, M. Yamaguchi, H. Tomizawa et al., Expression and Function of Toll-Like Receptors in Eosinophils: Activation by Toll-Like Receptor 7 Ligand, The Journal of Immunology, vol.171, issue.8, pp.3977-82, 2003.
DOI : 10.4049/jimmunol.171.8.3977

G. Woerly, N. Roger, S. Loiseau, and M. Capron, Expression of Th1 and Th2 Immunoregulatory Cytokines by Human Eosinophils, International Archives of Allergy and Immunology, vol.118, issue.2-4, pp.95-102, 1999.
DOI : 10.1159/000024038

G. Woerly, P. Lacy, A. B. Younes, N. Roger, S. Loiseau et al., Human eosinophils express and release IL-13 following CD28-dependent activation, J Leukoc Biol, vol.72, pp.769-79, 2002.

M. Yazdanbakhsh, P. C. Tai, C. J. Spry, G. J. Gleich, R. et al., Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni, J Immunol, vol.138, pp.3443-3450, 1987.

J. D. Young, C. G. Peterson, P. Venge, and C. , Mechanism of membrane damage mediated by human eosinophil cationic protein, Nature, vol.260, issue.6070, pp.613-619, 1986.
DOI : 10.1038/321613a0

V. Decot and M. Capron, Le polynucl??aire ??osinophile, La Presse M??dicale, vol.35, issue.1, pp.113-137, 2006.
DOI : 10.1016/S0755-4982(06)74534-1

A. S. Gounni, B. Lamkhioued, K. Ochiai, Y. Tanaka, E. Delaporte et al., High-affinity IgE receptor on eosinophils is involved in defence against parasites, Nature, vol.367, issue.6459, pp.183-189, 1994.
DOI : 10.1038/367183a0

S. Nutten, J. P. Papin, G. Woerly, D. W. Dunne, J. Macgregor et al., Selectin and Lewisx are required as co-receptors in antibody-dependent cell-mediated cytotoxicity of human eosinophils toSchistosoma mansoni schistosomula, European Journal of Immunology, vol.121, issue.3, pp.799-808, 1999.
DOI : 10.1002/(SICI)1521-4141(199903)29:03<799::AID-IMMU799>3.0.CO;2-1

L. Svensson and C. Wenneras, Human eosinophils selectively recognize and become activated by bacteria belonging to different taxonomic groups, Microbes and Infection, vol.7, issue.4, pp.720-728, 2005.
DOI : 10.1016/j.micinf.2005.01.010

A. L. Stenfeldt and C. Wenneras, Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils, Immunology, vol.171, issue.4, pp.605-619, 2004.
DOI : 10.1182/blood.V97.1.235

M. A. Ionescu, J. Rivet, M. Daneshpouy, J. Briere, P. Morel et al., In situ eosinophil activation in 26 primary cutaneous T-cell lymphomas with blood eosinophilia, Journal of the American Academy of Dermatology, vol.52, issue.1, pp.32-41, 2005.
DOI : 10.1016/j.jaad.2004.03.003

A. Munitz and F. Levi-schaffer, Eosinophils: 'new' roles for 'old' cells, Allergy, vol.162, issue.3, pp.268-75, 2004.
DOI : 10.1172/JCI200315719

M. J. Fernandez-acenero, M. Galindo-gallego, J. Sanz, A. , and A. , Prognostic influence of tumor???associated eosinophilic infiltrate in colorectal carcinoma, Cancer, vol.88, issue.7, pp.1544-1552, 2000.
DOI : 10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.3.CO;2-J

A. Munitz, I. Bachelet, S. Fraenkel, G. Katz, O. Mandelboim et al., 2B4 (CD244) Is Expressed and Functional on Human Eosinophils, The Journal of Immunology, vol.174, issue.1, pp.2-4, 2005.
DOI : 10.4049/jimmunol.174.1.110

S. A. Cormier, A. G. Taranova, C. Bedient, T. Nguyen, C. Protheroe et al., Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response, Journal of Leukocyte Biology, vol.79, issue.6, pp.1131-1140, 2006.
DOI : 10.1189/jlb.0106027

J. Mattes, M. Hulett, W. Xie, S. Hogan, M. E. Rothenberg et al., Immunotherapy of Cytotoxic T Cell???resistant Tumors by T Helper 2 Cells, The Journal of Experimental Medicine, vol.56, issue.3, pp.387-93, 2003.
DOI : 10.1056/NEJM199805283382206

D. Dombrowicz and M. Capron, Eosinophils, allergy and parasites, Current Opinion in Immunology, vol.13, issue.6, pp.716-736, 2001.
DOI : 10.1016/S0952-7915(01)00284-9

V. Decot, G. Woerly, M. Loyens, S. Loiseau, B. Quatannens et al., Heterogeneity of Expression of IgA Receptors by Human, Mouse, and Rat Eosinophils, The Journal of Immunology, vol.174, issue.2, pp.628-663, 2005.
DOI : 10.4049/jimmunol.174.2.628

H. Kayaba, D. Dombrowicz, G. Woerly, J. P. Papin, S. Loiseau et al., Human Eosinophils and Human High Affinity IgE Receptor Transgenic Mouse Eosinophils Express Low Levels of High Affinity IgE Receptor, but Release IL-10 upon Receptor Activation, The Journal of Immunology, vol.167, issue.2, pp.995-1003, 2001.
DOI : 10.4049/jimmunol.167.2.995

D. Dombrowicz, B. Quatannens, J. P. Papin, A. Capron, and M. Capron, Expression of a Functional Fc??RI on Rat Eosinophils and Macrophages, The Journal of Immunology, vol.165, issue.3, pp.1266-71, 2000.
DOI : 10.4049/jimmunol.165.3.1266

K. Honda, Y. Yamada, C. Cui, N. Saito, H. Kayaba et al., Effect of Eotaxin on the Generationof Reactive Oxygen Species from Eosinophil Cell Line, YY-1, International Archives of Allergy and Immunology, vol.120, issue.1, pp.48-50, 1999.
DOI : 10.1159/000053594

M. A. Baumann, P. , and C. C. , The Aml14 and Aml14.3D10 Cell Lines: A Long&hyphen;Overdue Model for the Study of Eosinophils and More, Stem Cells, vol.85, issue.1, pp.16-24, 1998.
DOI : 10.1002/stem.160016

M. Mayumi, EoL-1, A Human Eosinophilic Cell Line, Leukemia & Lymphoma, vol.144, issue.3, pp.243-50, 1992.
DOI : 10.1016/0008-8749(91)90177-D

J. H. Griffin, J. Leung, R. J. Bruner, M. A. Caligiuri, and R. Briesewitz, Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome, Proceedings of the National Academy of Sciences, vol.100, issue.13, pp.7830-7835, 2003.
DOI : 10.1073/pnas.0932698100

M. Suzuki, M. Kato, H. Hanaka, T. Izumi, and A. Morikawa, Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils, Journal of Allergy and Clinical Immunology, vol.112, issue.1, pp.126-159, 2003.
DOI : 10.1067/mai.2003.1515

L. Prin, M. Capron, A. B. Tonnel, O. Bletry, and A. Capron, Heterogeneity of Human Peripheral Blood Eosinophils: Variability in Cell Density and Cytotoxic Ability in Relation to the Level and the Origin of Hypereosinophilia, International Archives of Allergy and Immunology, vol.72, issue.4, pp.336-382, 1983.
DOI : 10.1159/000234893

F. Davoine, I. Labonte, C. Ferland, B. Mazer, J. Chakir et al., Role and Modulation of CD16 Expression on Eosinophils by Cytokines and Immune Complexes, International Archives of Allergy and Immunology, vol.134, issue.2, pp.165-72, 2004.
DOI : 10.1159/000078650

L. Ag-specific and . Lysis, Protocol was adapted from protocol described previously (22) Briefly Colo-205 cells were first stained with PKH26 and then with CFSE. Lysis of Colo-205 was measured by the percentage of PKH-26 high positive cells who presented decreased CFSE fluorescence

. Gmbh, After washing, cells were incubated with a goat

B. Granzyme, GzmB) (5'-GCTGGATGGAATCCTCTTCA-3' and 5'-GCCACGTCTCTTGTCCAAA-3') 57, p.5

H. Granzyme and . Gzmh, ATTTTCGTCCTTGCTGTTGG-3' and 5'GTTTCCTTGAAGGTGGCTGT-3') 57,5°C, CD8 (5'-CTATACCTCTCCCAAAACAAgCCC-3' and 5'-CCCAgATGTAgATATCACAggCGA-3') 56°C, ?2-microglobulin (5'-CAGCGTACTCCAAAGATTCAGGT-3' and 5'-TGGAGACAGCACTCAAAGTAGAA-3, p.52

M. E. Rothenberg and S. P. Hogan, THE EOSINOPHIL, Annual Review of Immunology, vol.24, issue.1, pp.147-174, 2006.
DOI : 10.1146/annurev.immunol.24.021605.090720

A. Munitz and F. Levi-schaffer, Eosinophils: 'new' roles for 'old' cells, Allergy, vol.162, issue.3, pp.268-275, 2004.
DOI : 10.1172/JCI200315719

R. Lotfi, J. J. Lee, and M. T. Lotze, Eosinophilic Granulocytes and Damage-associated Molecular Pattern Molecules (DAMPs), Journal of Immunotherapy, vol.30, issue.1, pp.16-28, 2007.
DOI : 10.1097/01.cji.0000211324.53396.f6

D. Lowe, J. Jorizzo, and M. S. Hutt, Tumour-associated eosinophilia: a review., Journal of Clinical Pathology, vol.34, issue.12, pp.1343-1348, 1981.
DOI : 10.1136/jcp.34.12.1343

L. Carrozzi and G. Viegi, Allergy and cancer: a biological and epidemiological rebus, Allergy, vol.161, issue.9, pp.1095-1097, 2005.
DOI : 10.1016/j.amjmed.2004.06.045

R. G. Dorta, G. Landman, L. P. Kowalski, J. R. Lauris, M. R. Latorre et al., Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas, Histopathology, vol.94, issue.2, pp.152-157, 2002.
DOI : 10.1046/j.1365-2559.2002.01437.x

M. Fujii, T. Yamashita, R. Ishiguro, M. Tashiro, and K. Kameyama, Significance of epidermal growth factor receptor and tumor associated tissue eosinophilia in the prognosis of patients with nasopharyngeal carcinoma, Auris Nasus Larynx, vol.29, issue.2, pp.175-181, 2002.
DOI : 10.1016/S0385-8146(01)00135-3

M. M. Goldsmith, D. A. Belchis, D. H. Cresson, W. D. Merritt, and F. B. Askin, The Importance of the Eosinophil in Head and Neck Cancer, Otolaryngology-Head and Neck Surgery, vol.124, issue.1, pp.27-33, 1992.
DOI : 10.1177/019459989210600124

H. J. Nielsen, U. Hansen, I. J. Christensen, C. M. Reimert, N. Brunner et al., Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue, The Journal of Pathology, vol.84, issue.4, pp.487-495, 1999.
DOI : 10.1002/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I

M. J. Fernandez-acenero, M. Galindo-gallego, J. Sanz, and A. Aljama, Prognostic influence of tumor???associated eosinophilic infiltrate in colorectal carcinoma, Cancer, vol.88, issue.7, pp.1544-1548, 2000.
DOI : 10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.3.CO;2-J

L. Simson, J. I. Ellyard, L. A. Dent, K. I. Matthaei, M. E. Rothenberg et al., Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance, The Journal of Immunology, vol.178, issue.7, pp.4222-4229, 2007.
DOI : 10.4049/jimmunol.178.7.4222

L. A. Spencer, C. T. Szela, S. A. Perez, C. L. Kirchhoffer, J. S. Neves et al., Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially, Journal of Leukocyte Biology, vol.85, issue.1, 2008.
DOI : 10.1189/jlb.0108058
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626765

R. A. Caruso, F. Fedele, V. Zuccala, M. G. Fracassi, and A. Venuti, Mast cell and eosinophil interaction in gastric carcinomas: ultrastructural observations, Anticancer Res, vol.27, pp.391-394, 2007.

R. A. Caruso, A. Ieni, F. Fedele, V. Zuccala, M. Riccardo et al., Degranulation Patterns of Eosinophils in Advanced Gastric Carcinoma: An Electron Microscopic Study, Ultrastructural Pathology, vol.90, issue.1, pp.29-36, 2005.
DOI : 10.3109/01913129209057825

E. Espinosa, C. Belmant, F. Pont, B. Luciani, R. Poupot et al., Chemical Synthesis and Biological Activity of Bromohydrin Pyrophosphate, a Potent Stimulator of Human gamma delta T Cells, Journal of Biological Chemistry, vol.276, issue.21, pp.18337-18344, 2001.
DOI : 10.1074/jbc.M100495200

M. E. Sheehy, A. B. Mcdermott, S. N. Furlan, P. Klenerman, and D. F. Nixon, A novel technique for the fluorometric assessment of T lymphocyte antigen specific lysis, Journal of Immunological Methods, vol.249, issue.1-2, pp.99-110, 2001.
DOI : 10.1016/S0022-1759(00)00329-X

A. Shibuya, L. L. Lanier, and J. H. Phillips, Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor, J Immunol, vol.161, pp.1671-1676, 1998.

B. Bade, H. E. Boettcher, J. Lohrmann, C. Hink-schauer, K. Bratke et al., Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes, International Immunology, vol.17, issue.11, pp.1419-1428, 2005.
DOI : 10.1093/intimm/dxh320

K. J. Livak and T. D. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

S. Tahara-hanaoka, K. Shibuya, Y. Onoda, H. Zhang, S. Yamazaki et al., Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112), Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112), pp.533-538, 2004.
DOI : 10.1093/intimm/dxh059

I. Bachelet, A. Munitz, D. Mankutad, and F. Levi-schaffer, Mast Cell Costimulation by CD226/CD112 (DNAM-1/Nectin-2): A NOVEL INTERFACE IN THE ALLERGIC PROCESS, Journal of Biological Chemistry, vol.281, issue.37, pp.27190-27196, 2006.
DOI : 10.1074/jbc.M602359200

J. P. Herbeuval, C. Lambert, O. Sabido, M. Cottier, P. Fournel et al., Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis, JNCI Journal of the National Cancer Institute, vol.95, issue.8, pp.611-621, 2003.
DOI : 10.1093/jnci/95.8.611

M. Poe, J. K. Wu, J. T. Blake, H. J. Zweerink, and N. H. Sigal, The enzymatic activity of human cytotoxic T-lymphocyte granzyme a and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175, Archives of Biochemistry and Biophysics, vol.284, issue.1, pp.215-218, 1991.
DOI : 10.1016/0003-9861(91)90286-R

Y. Kato, Y. Tanaka, M. Hayashi, K. Okawa, and N. Minato, Involvement of CD166 in the Activation of Human ????T Cells by Tumor Cells Sensitized with Nonpeptide Antigens, The Journal of Immunology, vol.177, issue.2, pp.877-884, 2006.
DOI : 10.4049/jimmunol.177.2.877

D. Pende, G. M. Spaggiari, S. Marcenaro, S. Martini, P. Rivera et al., Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112), CD155) and Nectin-2 (CD112), pp.2066-2073, 2005.
DOI : 10.1182/blood-2004-09-3548

M. Elishmereni, I. Bachelet, and F. Levi-schaffer, DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders, Curr Opin Investig Drugs, vol.9, pp.491-496, 2008.

R. Castriconi, A. Dondero, M. V. Corrias, E. Lanino, D. Pende et al., Natural Killer Cell-Mediated Killing of Freshly Isolated Neuroblastoma Cells: Critical Role of DNAX Accessory Molecule-1-Poliovirus Receptor Interaction, Cancer Research, vol.64, issue.24, pp.9180-9184, 2004.
DOI : 10.1158/0008-5472.CAN-04-2682

M. Carlsten, N. K. Bjorkstrom, H. Norell, Y. Bryceson, T. Van-hall et al., DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells, Cancer Research, vol.67, issue.3, pp.1317-1325, 2007.
DOI : 10.1158/0008-5472.CAN-06-2264

K. Shibuya, L. L. Lanier, J. H. Phillips, H. D. Ochs, K. Shimizu et al., Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule, Immunity, vol.11, issue.5, pp.615-623, 1999.
DOI : 10.1016/S1074-7613(00)80136-3

J. Shirakawa, Y. Wang, S. Tahara-hanaoka, S. Honda, K. Shibuya et al., LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell, International Immunology, vol.18, issue.6, pp.951-957, 2006.
DOI : 10.1093/intimm/dxl031

M. Corvaisier, A. Moreau-aubry, E. Diez, J. Bennouna, J. F. Mosnier et al., V??9V??2 T Cell Response to Colon Carcinoma Cells, The Journal of Immunology, vol.175, issue.8, pp.5481-5488, 2005.
DOI : 10.4049/jimmunol.175.8.5481

S. Lantero, G. Alessandri, D. Spallarossa, L. Scarso, and G. A. Rossi, LFA-1 expression by blood eosinophils is increased in atopic asthmatic children and is involved in eosinophil locomotion, European Respiratory Journal, vol.12, issue.5, pp.1094-1098, 1998.
DOI : 10.1183/09031936.98.12051094

A. Munitz, I. Bachelet, F. D. Finkelman, M. E. Rothenberg, and F. Levi-schaffer, CD48 Is Critically Involved in Allergic Eosinophilic Airway Inflammation, American Journal of Respiratory and Critical Care Medicine, vol.175, issue.9, pp.911-918, 2007.
DOI : 10.1164/rccm.200605-695OC

A. Munitz, I. Bachelet, R. Eliashar, M. Khodoun, F. D. Finkelman et al., CD48 Is an Allergen and IL-3-Induced Activation Molecule on Eosinophils, The Journal of Immunology, vol.177, issue.1, pp.77-83, 2006.
DOI : 10.4049/jimmunol.177.1.77

M. H. Brown, K. Boles, P. A. Van-der-merwe, V. Kumar, P. A. Mathew et al., 2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48, The Journal of Experimental Medicine, vol.89, issue.11, pp.2083-2090, 1998.
DOI : 10.1084/jem.185.3.393

J. A. Trapani and M. J. Smyth, Functional significance of the perforin/granzyme cell death pathway, Nature Reviews Immunology, vol.2, issue.10, pp.735-747, 2002.
DOI : 10.1038/nri911

K. Hochegger, P. Eller, and A. R. Rosenkranz, Granzyme A: an additional weapon of human polymorphonuclear neutrophils (PMNs) in innate immunity?, Blood, vol.103, issue.3, p.1176, 2004.
DOI : 10.1182/blood-2003-10-3708

K. Hochegger, P. Eller, J. M. Huber, D. Bernhard, G. Mayer et al., Expression of granzyme A in human polymorphonuclear neutrophils, Immunology, vol.72, issue.2, pp.166-173, 2007.
DOI : 10.1016/0952-7915(93)90087-9

D. Chowdhury and J. Lieberman, Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death, Annual Review of Immunology, vol.26, issue.1, pp.389-420, 2008.
DOI : 10.1146/annurev.immunol.26.021607.090404

C. Palm-apergi, A. Lorents, K. Padari, M. Pooga, and M. Hallbrink, The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake, The FASEB Journal, vol.23, issue.1, 2008.
DOI : 10.1096/fj.08-110254

Y. Yoshikawa, H. Hirayasu, S. Tsuzuki, and T. Fushiki, Granzyme A Causes Detachment of Alveolar Epithelial A549 Cells Accompanied by Promotion of Interleukin-8 Release, Bioscience, Biotechnology, and Biochemistry, vol.200, issue.1/2, pp.2481-2484, 2008.
DOI : 10.1006/cimm.1996.0187

H. Hirayasu, Y. Yoshikawa, S. Tsuzuki, and T. Fushiki, A Lymphocyte Serine Protease Granzyme A Causes Detachment of a Small-Intestinal Epithelial Cell Line (IEC-6), Bioscience, Biotechnology, and Biochemistry, vol.72, issue.9, pp.2294-2302, 2008.
DOI : 10.1271/bbb.80140

H. Hirayasu, Y. Yoshikawa, S. Tsuzuki, and T. Fushiki, A Role of a Lymphocyte Tryptase, Granzyme A, in Experimental Ulcerative Colitis, Bioscience, Biotechnology, and Biochemistry, vol.175, issue.12, pp.234-237, 2007.
DOI : 10.1006/cimm.1995.1184

P. K. Chattopadhyay, M. R. Betts, D. A. Price, E. Gostick, H. Horton et al., The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression, Journal of Leukocyte Biology, vol.85, issue.1, 2008.
DOI : 10.1189/jlb.0208107

D. L. Newton and S. M. Rybak, Unique Recombinant Human Ribonuclease and Inhibition of Kaposi's Sarcoma Cell Growth, JNCI Journal of the National Cancer Institute, vol.90, issue.23, pp.1787-1791, 1998.
DOI : 10.1093/jnci/90.23.1787

T. Maeda, M. Kitazoe, H. Tada, R. De-llorens, D. S. Salomon et al., Growth inhibition of mammalian cells by eosinophil cationic protein, European Journal of Biochemistry, vol.16, issue.1, pp.307-316, 2002.
DOI : 10.1046/j.0014-2956.2001.02653.x

C. Chang, D. L. Newton, S. M. Rybak, and A. Wlodawer, Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities, Journal of Molecular Biology, vol.317, issue.1, pp.119-130, 2002.
DOI : 10.1006/jmbi.2002.5406

E. Carreras, E. Boix, S. Navarro, H. F. Rosenberg, C. M. Cuchillo et al., Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation, Molecular and Cellular Biochemistry, vol.24, issue.1-2, pp.1-7, 2005.
DOI : 10.1007/s11010-005-4777-2

J. D. Young, C. G. Peterson, P. Venge, and Z. A. Cohn, Mechanism of membrane damage mediated by human eosinophil cationic protein, Nature, vol.260, issue.6070, pp.613-616, 1986.
DOI : 10.1038/321613a0

S. Navarro, J. Aleu, M. Jimenez, E. Boix, C. M. Cuchillo et al., The cytotoxicity of eosinophil cationic protein/ribonuclease 3 on eukaryotic cell lines takes place through its aggregation on the cell membrane, Cellular and Molecular Life Sciences, vol.65, issue.2, pp.324-337, 2008.
DOI : 10.1007/s00018-007-7499-7