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Theses

Glycoligands et Glycocomplexes – exploration de la chimie de coordination d'une nouvelle famille de ligands chiraux

Abstract : Glycoligands are metal chelators centred on carbohydrate scaffolds. They were obtained by functionalisation of monosaccharides with Lewis bases. Systematic variations of the central platform were performed (pyranoses and furanoses with various configurations and conformations) in the case of the ligands bearing three 2-picolyl ether functions (triether ligands). We have also considered the functionalisation of aminodeoxy-furanoses to yield aminodeoxy and diamino ligands. The complexing properties of this family of ligands were studied for divalent late transition 3d metal cations. The complexes were characterised structu- rally and spectroscopically. Some of the complexes were studied by circular dichroism (CD) spectroscopy. The diastereoselective nature of the complex synthesis was outlined as well as an empirical correlation between the pattern of the CD signal and the conformation of the pyranose or furanose scaffold. In a selected case, the thermochemical characterization of the glycoligand complexation reaction was performed by isothermal titration calorimetry. This study evidenced the effect of the inclusion of the chelating site in a cyclic pyranoside. The superoxide dismutase-like activity of an air-oxidised Mn(III)-diaminoglycocomplex was assayed by the means of the McCord-Fridovich test
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https://tel.archives-ouvertes.fr/tel-00369835
Contributor : Federico Cisnetti <>
Submitted on : Monday, June 1, 2009 - 1:18:00 PM
Last modification on : Wednesday, October 14, 2020 - 4:00:11 AM
Long-term archiving on: : Wednesday, September 22, 2010 - 12:53:35 PM

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  • HAL Id : tel-00369835, version 2

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Federico Cisnetti. Glycoligands et Glycocomplexes – exploration de la chimie de coordination d'une nouvelle famille de ligands chiraux. Chimie. Université Paris Sud - Paris XI, 2007. Français. ⟨tel-00369835v2⟩

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