New antiretroviral drugs in clinical use, 2006. ,
Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters, ABCC (MRP), and ABCG2 (BCRP) efflux transporters, pp.231-259, 2006. ,
DOI : 10.1080/10915810600746023
Discordance of P-glycoprotein expression and function in acute leukemia, Adv.Exp.Med.Biol, vol.457, issue.13, pp.107-118, 1999. ,
Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier, LeCluyse, M. Negishi, and H, pp.1525-1532, 2006. ,
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers, 2007. ,
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance, J.Antimicrob.Chemother. Biochem.Biophys.Res.Commun, vol.52, issue.17, pp.354-358345, 1995. ,
Selection and maintenance of multidrug-resistant cells, Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society--USA panel, pp.248-258827, 1998. ,
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts, Biochemical and Biophysical Research Communications, vol.310, issue.3, pp.824-82967, 1992. ,
DOI : 10.1016/j.bbrc.2003.09.086
Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells, FEBS Letters, vol.30, issue.1-2, pp.99-104806, 1996. ,
DOI : 10.1016/0014-5793(96)00237-2
Functional involvement of multidrug resistance-associated protein 4, 2007. ,
Transcriptional Regulation and Characterization of the Promoter Region of the Human ABCC6 Gene, Journal of Investigative Dermatology, vol.126, issue.2, pp.325-335, 2006. ,
DOI : 10.1038/sj.jid.5700065
ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages, Antivir.Ther, vol.9, pp.519-528, 2004. ,
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid Xactivated receptor, and constitutive androstane receptor, 2002. ,
The first once-daily single-tablet regimen for the treatment of HIV-infected patients, Drugs of Today, vol.43, issue.7, pp.427-442, 2007. ,
DOI : 10.1358/dot.2007.43.7.1086178
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs, 2000. ,
Multidrug resistance protein (MRP) activity in normal mature leukocytes and CD34-positive hematopoietic cells from peripheral blood, Life Sci, vol.68, pp.1323-1331, 2001. ,
1 Multidrug Transporter, Biochemistry, vol.37, issue.11, pp.3594-3601, 1998. ,
DOI : 10.1021/bi972709x
Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients, Blood, vol.91, pp.4480-4488, 1998. ,
Abstr, 2006. ,
MS method for the simultaneous quantitative determination of Abacavir, Lamivudine and Tenofovir in human plasma ,
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family, NeuroRX, vol.10, issue.Suppl 23, pp.86-98, 2005. ,
DOI : 10.1602/neurorx.2.1.86
Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC- PK1 cells, Eur.J.Pharmacol, vol.483, pp.19-28, 2004. ,
Predictors of treatment failure during highly active antiretroviral therapy (racing trial), Eur.J.Med.Res, vol.7, pp.341-346, 2002. ,
Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo, 2002. ,
Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions Mechanisms and strategies to overcome multiple drug resistance in cancer Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line, Mol.Pharmacol. FEBS Lett. J.Pharm.Sci, vol.64, issue.90, pp.1259-1269, 2001. ,
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis, 2006. ,
Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells, J.Mass Spectrom, vol.43, pp.224-233, 2008. ,
IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES, Drug Metabolism and Disposition, vol.34, issue.5, pp.786-792, 2006. ,
DOI : 10.1124/dmd.105.008615
Mechanism of active renal tubular efflux of tenofovir, Antimicrob.Agents Chemother, vol.50, pp.3297-3304, 2006. ,
Cellular export of drugs and signaling molecules by the ATPbinding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5), Drug Metab Rev, vol.37, pp.253-278, 2005. ,
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein, 2007. ,
Differential modulation of Pglycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture, 2002. ,
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux, Nature Medicine, vol.7, issue.5, pp.584-590, 2001. ,
DOI : 10.1038/87912
Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice, J Pharmacol.Exp.Ther, vol.302, pp.742-750, 2002. ,
Lopinavir: acute exposure inhibits Pglycoprotein ; extended exposure induces P-glycoprotein, AIDS, vol.17, pp.1092-1094, 2003. ,
Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by Nucleoside, Nucleotide, and Non-Nucleoside Reverse Transcriptase Inhibitors, Drug Metabolism and Disposition, vol.35, issue.3, pp.340-344, 2007. ,
DOI : 10.1124/dmd.106.012765
Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors, Eur.J.Pharmacol, vol.579, pp.104-109, 2008. ,
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs, Proc.Natl.Acad.Sci.U.S A, vol.97, pp.7476-7481, 2000. ,
Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood???brain barrier, Brain Research, vol.971, issue.2, pp.221-231, 2003. ,
DOI : 10.1016/S0006-8993(03)02401-6
Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome, N Engl J Med, vol.332, issue.14, pp.934-940, 1995. ,
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 ,
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites., Proceedings of the National Academy of Sciences, vol.86, issue.2, pp.695-698, 1989. ,
DOI : 10.1073/pnas.86.2.695
Pglycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir, Mol Pharmacol, vol.59, issue.4, pp.806-813, 2001. ,
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors., Journal of Clinical Investigation, vol.101, issue.2, pp.289-294, 1998. ,
DOI : 10.1172/JCI1269
HTLV-III, AIDS, and the Brain, New England Journal of Medicine, vol.313, issue.24, pp.1538-1540, 1985. ,
DOI : 10.1056/NEJM198512123132409
From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance, Cellular and Molecular Life Sciences, vol.58, issue.7, pp.931-959, 2001. ,
DOI : 10.1007/PL00000912
Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison, Int. Journal of Clinical Pharmacology and Therapeutics, vol.38, issue.03, pp.111-121, 2000. ,
DOI : 10.5414/CPP38111
Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line, Journal of Pharmaceutical Sciences, vol.90, issue.11, pp.1829-1837, 2001. ,
DOI : 10.1002/jps.1133
Lopinavir, AIDS, vol.17, issue.7, pp.1092-1094, 2003. ,
DOI : 10.1097/00002030-200305020-00023
Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells, Journal of Pharmacy and Pharmacology, vol.306, issue.Suppl. 2, pp.947-953, 2007. ,
DOI : 10.1211/jpp.59.7.0006
The Effects of Protease Inhibitors and Nonnucleoside Reverse Transcriptase Inhibitors on P-Glycoprotein Expression in Peripheral Blood Mononuclear Cells In Vitro, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.33, issue.5, pp.551-556, 2003. ,
DOI : 10.1097/00126334-200308150-00001
Effect of protease inhibitor-containing regimens on lymphocyte multidrug resistance transporter expression, Journal of Antimicrobial Chemotherapy, vol.52, issue.3, pp.354-358, 2003. ,
DOI : 10.1093/jac/dkg381
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs, AIDS, vol.16, issue.17, pp.2295-2301, 2002. ,
DOI : 10.1097/00002030-200211220-00009
HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2), Journal of Pharmacology and Experimental Therapeutics, vol.310, issue.1, pp.334-341, 2004. ,
DOI : 10.1124/jpet.104.065342
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs, Journal of Antimicrobial Chemotherapy, vol.59, issue.2, pp.238-245, 2007. ,
DOI : 10.1093/jac/dkl474
ATAZANAVIR: EFFECTS ON P-GLYCOPROTEIN TRANSPORT AND CYP3A METABOLISM IN VITRO, Drug Metabolism and Disposition, vol.33, issue.6, pp.764-770, 2005. ,
DOI : 10.1124/dmd.104.002931
Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein, Journal of Antimicrobial Chemotherapy, vol.60, issue.1, pp.61-67, 2007. ,
DOI : 10.1093/jac/dkm135
Atazanavir inhibits P-glycoprotein and multidrug resistanceassociated protein efflux activity, J Acquir Immune Defic Syndr, vol.39, issue.5, pp.635-637, 2005. ,
Evaluation of Drug Penetration into the Brain: A Double Study by in Vivo Imaging with Positron Emission Tomography and Using an in Vitro Model of the Human Blood-Brain Barrier, Journal of Pharmacology and Experimental Therapeutics, vol.316, issue.1, pp.79-86, 2006. ,
DOI : 10.1124/jpet.105.089102
A co-culture-based model of human blood???brain barrier: application to active transport of indinavir and in vivo???in vitro correlation, Brain Research, vol.927, issue.2, pp.153-167, 2002. ,
DOI : 10.1016/S0006-8993(01)03337-6
Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo, Journal of Immunological Methods, vol.262, issue.1-2, pp.159-165, 2002. ,
DOI : 10.1016/S0022-1759(02)00020-0
Preparation of an Antibody Recognizing both Human and Rodent MRP1, Biochemical and Biophysical Research Communications, vol.288, issue.4, pp.1064-1068, 2001. ,
DOI : 10.1006/bbrc.2001.5885
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein, Biochemical Pharmacology, vol.73, issue.10 ,
DOI : 10.1016/j.bcp.2007.01.027
Pgp and MRP activities using calcein- AM are prognostic factors in adult acute myeloid leukemia patients, Blood, vol.91, issue.12, pp.4480-4488, 1998. ,
The Leukotriene LTD4 Receptor Antagonist Mk571 Specifically Modulates MRP Associated Multidrug Resistance, Biochemical and Biophysical Research Communications, vol.208, issue.1, pp.345-352, 1995. ,
DOI : 10.1006/bbrc.1995.1344
IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES, Drug Metabolism and Disposition, vol.34, issue.5, pp.786-792, 2006. ,
DOI : 10.1124/dmd.105.008615
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C, Mol Cancer Ther, vol.1, issue.6, pp.417-425, 2002. ,
Effect of PSC 833, a potent inhibitor of P-glycoprotein, on the growth of astrocytoma cells in vitro, Cancer Letters, vol.198, issue.1, pp.21-27, 2003. ,
DOI : 10.1016/S0304-3835(03)00270-2
Quantitative Immunoassay To Measure Plasma and Intracellular Atazanavir Levels: Analysis of Drug Accumulation in Cultured T Cells, Antimicrobial Agents and Chemotherapy, vol.51, issue.2, pp.405-411, 2007. ,
DOI : 10.1128/AAC.00730-06
Interaction of Ritonavir on Tissue Distribution of a [14C]L-Valinamide, a Potent Human Immunodeficiency Virus-1 Protease Inhibitor, in Rats Using Quantitative Whole-Body Autoradiography, Drug Metabolism and Disposition, vol.30, issue.11, pp.1164-1169, 2002. ,
DOI : 10.1124/dmd.30.11.1164
The distribution of the anti-HIV drug, tenofovir (PMPA), into the brain, CSF and choroid plexuses, Cerebrospinal Fluid Research, vol.3, issue.1, p.1, 2006. ,
DOI : 10.1186/1743-8454-3-1
Atazanavir, Drugs, vol.17, issue.9, pp.1679-1693, 2003. ,
DOI : 10.2165/00003495-200363160-00003
Interactions between Atazanavir-Ritonavir and Tenofovir in Heavily Pretreated Human Immunodeficiency Virus-Infected Patients, Antimicrobial Agents and Chemotherapy, vol.48, issue.6, pp.2091-2096, 2004. ,
DOI : 10.1128/AAC.48.6.2091-2096.2004
Pregnane X receptor up-regulation of Pglycoprotein expression and transport function at the blood-brain barrier, Mol Pharmacol, vol.66, issue.3, pp.413-419, 2004. ,
Transcription Factor and Drug-Metabolizing Enzyme Gene Expression in Lymphocytes from Healthy Human Subjects, Drug Metabolism and Disposition, vol.36, issue.1, 2007. ,
DOI : 10.1124/dmd.107.017228
Haase AT Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection Science, pp.960-964, 1997. ,
The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro J Acquir Immune Defic Syndr, pp.551-557, 2003. ,
Structure of MsbA from E. coli: A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters, Science, vol.293, issue.5536, pp.1793-800, 2001. ,
DOI : 10.1126/science.293.5536.1793
Branstetter DG Metabolism of the HIV-1 reverse transcriptase inhibitor delavirdine in mice Drug Metab Dispos, pp.828-867, 1997. ,
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells, Cell, vol.66, issue.1, pp.85-94, 1991. ,
DOI : 10.1016/0092-8674(91)90141-K
Enfuvirtide, Expert Opinion on Investigational Drugs, vol.72, issue.12, pp.1837-1880, 2002. ,
DOI : 10.1128/AAC.46.6.1896-1905.2002
Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity Mol Pharmacol, pp.625-633, 1991. ,
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells Nature, pp.108-122, 2005. ,
Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters, International Journal of Toxicology, vol.876, issue.4, pp.231-59, 2006. ,
DOI : 10.1080/10915810600746023
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection Nature, pp.183-191, 1997. ,
Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection, Proceedings of the National Academy of Sciences, vol.95, issue.15, pp.8869-73, 1998. ,
DOI : 10.1073/pnas.95.15.8869
Latent reservoirs of HIV: Obstacles to the eradication of virus, Proceedings of the National Academy of Sciences, vol.96, issue.20, pp.10958-61, 1999. ,
DOI : 10.1073/pnas.96.20.10958
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies Cancer Res, pp.4557-63, 1994. ,
Scheper RJ Tissue distribution of the multidrug resistance protein, Am J Pathol, vol.148, issue.4, pp.1237-1284, 1996. ,
Localization of multidrug resistance-associated DNA sequences to human chromosome 7, Somatic Cell and Molecular Genetics, vol.40, issue.4 ,
DOI : 10.1007/BF01570737
Expression of a multidrug-resistance gene in human tumors and tissues., Proceedings of the National Academy of Sciences, vol.84, issue.1, pp.265-274, 1987. ,
DOI : 10.1073/pnas.84.1.265
Fauci AS Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line Science, pp.800-802, 1987. ,
Fauci AS Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow Science, pp.919-941, 1988. ,
Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients, Journal of Antimicrobial Chemotherapy, vol.58, issue.5, pp.1009-1025, 2006. ,
DOI : 10.1093/jac/dkl379
Back DJ Effect of protease inhibitor-containing regimens on lymphocyte multidrug resistance transporter expression J Antimicrob Chemother, pp.354-362, 2003. ,
oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2- (hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus Antimicrob Agents Chemother, pp.2285-92, 1993. ,
Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer Eur J Cancer, pp.935-943, 1999. ,
Occludin: a novel integral membrane protein localizing at tight junctions, The Journal of Cell Biology, vol.123, issue.6, pp.1777-88, 1993. ,
DOI : 10.1083/jcb.123.6.1777
Gottesman MM Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter, FASEB J, vol.14, issue.3, pp.516-538, 2000. ,
Bendayan R Functional expression of P-glycoprotein in rat brain microglia, J Pharmacol Exp Ther, vol.299, issue.1, pp.204-216, 2001. ,
Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients Blood, Jun, vol.1591, issue.12, pp.4480-4488, 1998. ,
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense, Toxicology and Applied Pharmacology, vol.204, issue.3, pp.216-253, 2005. ,
DOI : 10.1016/j.taap.2004.10.012
Ellis RJ; the HIV Neurobehavioral Research Center Group Lopinavir with Ritonavir Reduces the HIV RNA Level in Cerebrospinal Fluid Clin Infect Dis, 2007. ,
Induction of multiple-drug resistance during anti-neoplastic chemotherapy in vitro, Int J Cancer, issue.4, pp.49630-49637, 1991. ,
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes Cancer Res, pp.8-13, 1999. ,
Molla A Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to human immunodeficiency virus protease inhibitors and impair viral replication Antimicrob Agents Chemother, Feb, vol.51, issue.2, pp.732-737, 2007. ,
Pharmacokinetics of emtricitabine, didanosine and efavirenz administered once-daily for the treatment of HIVinfected adults ,
van der Horst CM Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease, AIDS Clinical Trials Group, vol.062 ,
Endothelial Claudin, The Journal of Cell Biology, vol.107, issue.1, pp.185-94, 1999. ,
DOI : 10.1083/jcb.120.2.477
Oral adverse effects due to the use of Nevirapine J Contemp Dent Pract, pp.84-90, 2008. ,
Brun-Vezinet F, Calvez V Conditions of "thymidine analog mutations" (TAMs) in naive patients treated with different combinations of d4T, Pathol Biol, vol.48, issue.5, pp.508-520, 2000. ,
Principles and practice of HIV-protease inhibitor pharmacoenhancement HIV Med, pp.105-118, 2001. ,
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport., Proceedings of the National Academy of Sciences, vol.91, issue.26, pp.13033-13040, 1994. ,
DOI : 10.1073/pnas.91.26.13033
Deeley RG Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions Mol Pharmacol, pp.1259-69, 2003. ,
Cytotoxic-T-Cell Responses, Viral Load, and Disease Progression in Early Human Immunodeficiency Virus Type 1 Infection, New England Journal of Medicine, vol.337, issue.18, pp.1267-74, 1997. ,
DOI : 10.1056/NEJM199710303371803
Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines Pharm Res, pp.811-819, 2004. ,
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells., Proceedings of the National Academy of Sciences, vol.83, issue.12, pp.4538-4580, 1986. ,
DOI : 10.1073/pnas.83.12.4538
Higgins CF Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis, J Biol Chem, vol.272, issue.16, pp.10685-94, 1997. ,
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor Mol Endocrinol, pp.1268-82, 2003. ,
Human Immunodeficiency Virus (HIV) Infection in Brains with AIDS-Related Leukoencephalopathy, AIDS Research and Human Retroviruses, vol.3, issue.4, pp.363-73, 1987. ,
DOI : 10.1089/aid.1987.3.363
Quantitative immunoassay to measure plasma and intracellular atazanavir levels: analysis of drug accumulation in cultured T cells Antimicrob Agents Chemother, Feb, vol.51, issue.2, pp.405-416, 2007. ,
Lipid Synthesis by Rat Brain Microvessel Endothelial Cells in Tissue Culture, Journal of Neuropathology and Experimental Neurology, vol.48, issue.4, pp.437-484, 1989. ,
DOI : 10.1097/00005072-198907000-00005
Rousseau F; FTC-301A Study Team Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: a randomized trial JAMA, pp.180-189, 2004. ,
Effect of PSC 833, a potent inhibitor of P-glycoprotein, on the growth of astrocytoma cells in vitro Cancer Lett, pp.21-28, 2003. ,
Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC ,
Lee FW Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus- 1 protease inhibitor, in rats using quantitative whole-body autoradiography Drug Metab Dispos, pp.1164-1173, 2002. ,
Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection J Infect Dis, pp.332-372, 2002. ,
Fridland A Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters Antimicrob Agents Chemother, pp.3157-62, 1998. ,
Rubin LL Signal transduction at the blood-brain barrier Biochem Soc Trans, pp.475-484, 1995. ,
Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS, Cell, vol.45, issue.5, pp.45637-45685, 1986. ,
DOI : 10.1016/0092-8674(86)90778-6
JF Factors affecting delivery of antiviral drugs to the brain Rev Med Virol, pp.105-138, 2005. ,
Cadherins and their connections: adhesion junctions have broader functions, Current Opinion in Cell Biology, vol.11, issue.5, pp.554-60, 1999. ,
DOI : 10.1016/S0955-0674(99)00027-7
Lamonica CA HIV-1 replication is controlled at the level of T cell activation and proviral integration EMBO J, pp.1551-60, 1990. ,
Hendrix CW Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects Antimicrob Agents Chemother, pp.2351-2359, 2007. ,
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein Biochem Pharmacol, pp.1573-81, 2007. ,
Greenblatt DJ Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture Pharm Res, pp.1038-1083, 2002. ,
Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1, Antimicrobial Agents and Chemotherapy, vol.46, issue.3 ,
DOI : 10.1128/AAC.46.3.708-715.2002
Konings WN The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating twosite (two-cylinder engine) mechanism EMBO J, pp.2503-2517, 2000. ,
Effect of Interleukin-2 on Intestinal P-glycoprotein Expression and Functionality in Mice, Journal of Pharmacology and Experimental Therapeutics, vol.302, issue.2, pp.742-50, 2002. ,
DOI : 10.1124/jpet.302.2.742
Hoetelmans RM High exposure to nevirapine in plasma is associated with an improved virological response in HIV-1-infected individuals AIDS, pp.1089-95, 2001. ,
Clinical experience with saquinavir AIDS, pp.21-25, 1995. ,
TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments, Journal of Virology, vol.79, issue.20, pp.12773-82, 2005. ,
DOI : 10.1128/JVI.79.20.12773-12782.2005
acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein AIDS, pp.1092-1096, 2003. ,
Nucleotide sequence of the AIDS virus, LAV, Cell, vol.40, issue.1, pp.9-17, 1985. ,
DOI : 10.1016/0092-8674(85)90303-4
Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53 Cancer Res, pp.5762-5771, 1998. ,
Rhodes RH Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections, Am J Pathol, vol.127, issue.2, pp.199-205, 1987. ,
Blaschke TF Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells J Acquir Immune Defic Syndr Hum Retrovirol, pp.203-212, 1998. ,
Dubois-Dalcq M Specific tropism of HIV-1 for microglial cells in primary human brain cultures Science, pp.549-53, 1990. ,
Kappes JC Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy Antimicrob Agents Chemother, pp.1896-905, 2002. ,
Inhibition of P-Glycoprotein by Newer Antidepressants, Journal of Pharmacology and Experimental Therapeutics, vol.305, issue.1, pp.197-204, 2003. ,
DOI : 10.1124/jpet.102.046532
Efferth T (a) Modulation of human BCRP (ABCG2) activity by anti-HIV drugs J Antimicrob Chemother, Feb, vol.59, issue.2, pp.238-283, 2007. ,
Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors Drug Metab Dispos, pp.340-344, 2007. ,
Haefeli WE Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors, Eur J Pharmacol, vol.579, pp.1-3104, 2008. ,
Yamazaki S The molecular epidemiology of HIV in Asia AIDS, pp.13-28, 1994. ,
Petropoulos CJ Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates J Infect Dis, pp.992-1000, 2003. ,
Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity, Antimicrobial Agents and Chemotherapy, vol.46, issue.11, pp.3437-3446, 2002. ,
DOI : 10.1128/AAC.46.11.3437-3446.2002
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites, J Virol, issue.4, pp.722846-54, 1998. ,
Borst P Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells Mol Pharmacol, pp.1321-1352, 2002. ,
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs, Proceedings of the National Academy of Sciences, vol.97, issue.13, pp.7476-81, 2000. ,
DOI : 10.1073/pnas.120159197
Soontornniyomkij V HIV mediates a productive infection of the brain AIDS, pp.2055-2064, 1999. ,
Role of human immunodeficiency virus and cytomegalovirus in AIDS encephalitis, Am J Pathol, vol.133, issue.1, pp.73-81, 1988. ,
Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients., Proceedings of the National Academy of Sciences, vol.83, issue.18, pp.7089-93, 1986. ,
DOI : 10.1073/pnas.83.18.7089
Martin MA Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus, Proc Natl Acad Sci U S A, issue.14, pp.835038-835080, 1986. ,
Regulation of HIV-1 latency by T-cell activation Cytokine, pp.63-74, 2007. ,
Sinko PJ Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2) Antimicrob Agents Chemother, pp.3456-62, 2002. ,
Oral absorption of the HIV protease inhibitors: a current update Adv Drug Deliv Rev, Oct, vol.1839, pp.1-3211, 1999. ,
Nephropathy and Establishment of a Renal Reservoir of HIV Type 1 during Primary Infection, New England Journal of Medicine, vol.344, issue.26, pp.1979-84, 2001. ,
DOI : 10.1056/NEJM200106283442604
Heneine W Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis Antivir Ther, Feb, vol.9, issue.1, pp.57-65, 2004. ,
Tight junctions of the blood???brain barrier, Vascular Pharmacology, vol.38, issue.6, pp.323-360, 2002. ,
DOI : 10.1016/S1537-1891(02)00200-8
Deeley RG Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung Clin Cancer Res, pp.2279-89, 1998. ,
Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat Brain Res, pp.313-319, 1998. ,
Jetter A Effect of an Antiretroviral Regimen Containing Ritonavir Boosted Lopinavir on Intestinal and Hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected Patients Clin Pharmacol Ther, 2008. ,
Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat Pharm Res, pp.865-72, 1997. ,