Skip to Main content Skip to Navigation
Theses

Barrière hémato-encéphalique humaine et endothéline 1 : régulation des transporteurs ABC et des cytokines inflammatoires

Abstract : The central nervous system is a complex and privileged organ protected by, among others, the blood-brain barrier (BBB). On this barrier are localised efflux pumps such as P-glycoprotein. The BBB is involved in neuro-inflammation associated to many cerebral diseases.
The endothelin 1 (ET-1) peptide seems to play a key role in the process. We have used an in vitro human autologous adult BBB model and an in vitro human foetal BBB model (co-culture of glial cells and brain microvascular endothelial cells) to evaluate ET-1's influence on the P-glycoprotein.
A difference was shown between the two models concerning Pgp's activity modulation by ET-1. We have also been looking at ET-1 induced Monocyte chemoattractant protein 1 and interleukin 8 secretions. The results show that ET-1 reduces Pgp's activity and induces MCP-1 and IL-8 secretion.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00364210
Contributor : Celine Lentz <>
Submitted on : Wednesday, February 25, 2009 - 2:00:51 PM
Last modification on : Monday, October 19, 2020 - 11:12:04 AM
Long-term archiving on: : Tuesday, June 8, 2010 - 9:08:27 PM

Identifiers

  • HAL Id : tel-00364210, version 1

Collections

Citation

Alexandra Hembury. Barrière hémato-encéphalique humaine et endothéline 1 : régulation des transporteurs ABC et des cytokines inflammatoires. Sciences du Vivant [q-bio]. Université Paris Sud - Paris XI, 2008. Français. ⟨tel-00364210⟩

Share

Metrics

Record views

456

Files downloads

5701