E. Migianu, I. Mallard, N. Bouchemal, and M. Lecouvey, One-pot synthesis of 1-hydroxymethylene-1,1-bisphosphonate partial esters, Tetrahedron Letters, vol.45, issue.23, pp.4511-4513, 2004.
DOI : 10.1016/j.tetlet.2004.04.047

C. Li and C. Yuan, Studies on organophosphorus compounds 68. A new and facile synthetic approach to alkylidenebisphosphonates., Tetrahedron Letters, vol.34, issue.9, pp.1515-1516, 1993.
DOI : 10.1016/S0040-4039(00)60333-7

M. P. Teulade and P. Savignac, Conversion directe par les alkyllithiens des phosphates en phosphonates ?? -lithies, Tetrahedron Letters, vol.28, issue.4, pp.405-408, 1987.
DOI : 10.1016/S0040-4039(00)95740-X

M. Teulade and P. Savignac, Alkylid??nediphosphonates et vinylphosphonates: une d??marche synth??tiques s??lective par voie carbanionique, Journal of Organometallic Chemistry, vol.304, issue.3, pp.283-300, 1986.
DOI : 10.1016/0022-328X(86)80147-4

H. R. Hays and T. J. Logan, gem-Diphosphinoalkanes. Preparation and Characterization, The Journal of Organic Chemistry, vol.31, issue.10, pp.3391-3394, 1966.
DOI : 10.1021/jo01348a064

W. Lehnert, Knoevenagel kondensationen mit TiCl4/base-IV, Tetrahedron, vol.30, issue.2, pp.301-305, 1974.
DOI : 10.1016/S0040-4020(01)91461-9

M. Lolli, L. Lazzarato, D. Stilo, A. Fruttero, R. Gasco et al., Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate, Journal of Organometallic Chemistry, vol.650, issue.1-2, pp.77-83, 2002.
DOI : 10.1016/S0022-328X(02)01179-8

P. Page, M. Mckenzie, and J. Gallagher, Novel Synthesis of Bis(phosphonic acid)???Steroid Conjugates, The Journal of Organic Chemistry, vol.66, issue.11, pp.3704-3708, 2001.
DOI : 10.1021/jo001489h

W. Wincler, T. Pieper, and B. K. Keppler, PREPARATION OF OCTAETHYL-3-AMINO-PENTANE-1,1,5,5-TETRAKISPHOSPHONATE BY CATALYTIC HYDROGENATION OF THE CORRESPONDING 3-NITRO-COMPOUND, Phosphorus, Sulfur, and Silicon and the Related Elements, vol.116, issue.1-4, pp.137-142, 1996.
DOI : 10.1021/jo00368a017

T. Bailly, R. Burgada, T. Prangé, and M. Lecouvey, Synthesis of tetradentate mixed bisphosphonates???new hydroxypyridinonate ligands for metal chelation therapy, Tetrahedron Letters, vol.44, issue.1, pp.189-192, 2003.
DOI : 10.1016/S0040-4039(02)02442-5

L. Wang, Z. Yang, J. Gao, K. Xu, H. Gu et al., A Biocompatible Method of Decorporation:?? Bisphosphonate-Modified Magnetite Nanoparticles to Remove Uranyl Ions from Blood, Journal of the American Chemical Society, vol.128, issue.41, pp.13358-13359, 2006.
DOI : 10.1021/ja0651355

V. Chaleix and M. Lecouvey, Synthesis of novel phosphonated tripodal ligands for actinides chelation therapy, Tetrahedron Letters, vol.48, issue.4, pp.703-706, 2007.
DOI : 10.1016/j.tetlet.2006.11.094

URL : https://hal.archives-ouvertes.fr/hal-00416610

T. Okauchi, T. Yano, T. Fukamachi, J. Ichikawa, and T. Minami, ??-Phosphonovinyl nonaflate: Their synthesis and cross-coupling reactions, Tetrahedron Letters, vol.40, issue.29, pp.5337-5340, 1999.
DOI : 10.1016/S0040-4039(99)00971-5

T. Yokomatsu, Y. Yoshida, N. Nakabayashi, and S. Shibuya, Simple and Efficient Method for Preparation of Conformationally Constrained Aminomethylene gem-Diphosphonate Derivatives via Beckmann Rearrangement, The Journal of Organic Chemistry, vol.59, issue.24, pp.7562-7564, 1994.
DOI : 10.1021/jo00103a070

S. E. Frost and J. M. Takala, Internal Dosimetry in the Canadian Uranium Industry, Radiation Protection Dosimetry, vol.53, issue.1-4, pp.249-254, 1994.
DOI : 10.1093/oxfordjournals.rpd.a082286

D. R. Fisher, M. J. Swint, R. L. Kathren, and D. U. Washington, Assessment of Accidental Intakes of Uranyl Acetylacetonate (UAA), Radiation Protection Dosimetry, vol.53, issue.1-4, pp.263-267, 1990.
DOI : 10.1093/oxfordjournals.rpd.a082289

P. Bérard, B. Quesne, B. Auriol, and J. Chalabreysse, Cutaneous Contamination after a Uranyl Nitrate Skin Burn: Incident Report, Radiation Protection Dosimetry, vol.53, issue.1-4, pp.269-272, 1994.
DOI : 10.1093/oxfordjournals.rpd.a082290

G. N. Stradling, D. M. Taylor, M. Hengé-napoli, ;. R. Wood, and T. , Treatment for Actinide-bearing Industrial Dusts and Aerosols, Radiation Protection Dosimetry, vol.87, issue.1, pp.41-50, 2000.
DOI : 10.1093/oxfordjournals.rpd.a032978

R. Wood, C. Sharp, P. Gourmelon, B. Le-guen, G. N. Stradling et al., Basic Physiological and Anatomical Data for use in Radiological Protection : Reference values Ann, 49 ICPR publication 89, pp.51-57, 2000.

B. M. De-rey, H. E. Lanfranchi, and R. L. , Percutaneous absorption of uranium compounds, Environmental Research, vol.30, issue.2, pp.480-491, 1983.
DOI : 10.1016/0013-9351(83)90233-5

H. C. Hodge and W. Neuman, Pharmacology and toxicology of uranium compounds 1949, 788 and 976-980. 1st edMcGraw-Hill New York, pp.433-443, 1998.

A. E. Gorden, J. Xu, K. N. Raymond, and P. W. Durbin, Rational Design of Sequestering Agents for Plutonium and Other Actinides, Chemical Reviews, vol.103, issue.11, pp.4207-4282, 2003.
DOI : 10.1021/cr990114x

M. Hengé-napoli, E. Ansoborlo, P. Houpert, H. Mirto, F. Paquet et al., Progress and Trends in In Vivo Chelation of Uranium, Radiation Protection Dosimetry, vol.79, issue.1, pp.449-452, 1998.
DOI : 10.1093/oxfordjournals.rpd.a032447

J. L. Domingo, A. Ortega, J. M. Llobet, and J. Corbella, Effectiveness of chelation therapy with time after acute uranium intoxication, Fundamental and Applied Toxicology, vol.14, issue.1, pp.88-95, 1990.
DOI : 10.1016/0272-0590(90)90234-B

M. H. Hengé-napoli, E. Ansoborlo, V. Chazel, P. Houpert, F. Paquet et al., Efficacy of ethane-1-hydroxy-1, 1-bisphosphonate (EHBP) for the decorporation of uranium after intramuscular contamination in rats, International Journal of Radiation Biology, vol.75, issue.11, pp.1473-1477, 1999.
DOI : 10.1080/095530099139331

M. A. Basinger, R. L. Forti, L. T. Burka, M. M. Jones, W. M. Mitchell et al., Phenolic chelating agents as antidotes for acute uranyl acetate intoxication in mice, Journal of Toxicology and Environmental Health, vol.8, issue.3, pp.237-246, 1983.
DOI : 10.1080/15287398309530338

P. W. Durbin, B. Kullgren, S. N. Ebbe, J. Xu, and K. N. Raymond, CHELATING AGENTS FOR URANIUM(VI): 2. EFFICACY AND TOXICITY OF TETRADENTATE CATECHOLATE AND HYDROXYPYRIDINONATE LIGANDS IN MICE, Health Physics, vol.78, issue.5, pp.511-521, 2000.
DOI : 10.1097/00004032-200005000-00008

S. Meunier, J. Siaugue, M. Sawicki, F. Calbour, S. Dézard et al., Modular Liquid-Phase Parallel Synthesis of a Highly Diverse Ligand Library, Journal of Combinatorial Chemistry, vol.5, issue.3, pp.201-204, 2003.
DOI : 10.1021/cc0200991

URL : https://hal.archives-ouvertes.fr/hal-00168475

B. M. Trost and G. R. Dake, Nucleophilic ??-Addition to Alkynoates. A Synthesis of Dehydroamino Acids, Journal of the American Chemical Society, vol.119, issue.32, pp.7595-7596, 1997.
DOI : 10.1021/ja971238z

M. Sawicki, J. Siaugue, C. Jacopin, C. Moulin, T. Bailly et al., Discovery of Powerful Uranyl Ligands from Efficient Synthesis and Screening, Chemistry - A European Journal, vol.42, issue.273, pp.3689-3697, 2005.
DOI : 10.1002/chem.200401056

URL : https://hal.archives-ouvertes.fr/hal-00168498

D. S. Marlin, M. M. Olmstead, and P. K. Mascharak, Extended structures controlled by intramolecular and intermolecular hydrogen bonding: a case study with pyridine-2,6-dicarboxamide, 1,3-benzenedicarboxamide and N,N???-dimethyl-2,6-pyridinedicarboxamide, Journal of Molecular Structure, vol.554, issue.2-3, pp.211-223, 2000.
DOI : 10.1016/S0022-2860(00)00673-6

F. L. Weitl, K. Raymond, and J. Amer, Ferric ion sequestering agents. 1. Hexadentate O-bonding N,N',N"-tris(2,3-dihydroxybenzoyl) derivatives of 1,5,9-triazacyclotridecane and 1,3,5-triaminomethylbenzene, Journal of the American Chemical Society, vol.101, issue.10, pp.2728-2731, 1979.
DOI : 10.1021/ja00504a039

R. Burgada, T. Bailly, T. Prangé, and M. Lecouvey, Synthetic strategy of new powerful tris-bisphosphonic ligands for chelation of uranyl, iron, and cobalt cations, Tetrahedron Letters, vol.48, issue.13, pp.2315-2319, 2007.
DOI : 10.1016/j.tetlet.2007.01.155

URL : https://hal.archives-ouvertes.fr/hal-00416608

M. Carriere, L. Avoscan, R. Collins, F. Carrot, H. Khodja et al., ) Proximal Cell Cytotoxicity, Chemical Research in Toxicology, vol.17, issue.3, pp.446-452, 2004.
DOI : 10.1021/tx034224h

T. Ye and M. A. Mckervey, Organic Synthesis with .alpha.-Diazo Carbonyl Compounds, Chemical Reviews, vol.94, issue.4, pp.1091-1160, 1994.
DOI : 10.1021/cr00028a010

A. M. Dennis, J. D. Korp, I. Bernal, R. A. Howard, and J. L. Bear, Crystal and molecular structure of the bis(pyridine) adduct of a dinuclear rhodium(II) complex with trifluoroacetamidato bridging ligands, Inorganic Chemistry, vol.22, issue.10, pp.1522-1529, 1983.
DOI : 10.1021/ic00152a020

D. Haigh, Rhodium carbenoid O-H insertion reactions with phenols; A facile method for the synthesis of trialkyl 2-aryloxyphosphonoacetates and their use in the preparation of 2-aryloxy-3-phenylpropanoates., Tetrahedron, vol.50, issue.10, p.3177, 1994.
DOI : 10.1016/S0040-4020(01)81116-9

J. Jung and M. A. Avery, An efficient synthesis of cyclic urethanes from Boc-protected amino acids through a metal triflate-catalyzed intramolecular diazocarbonyl insertion reaction, Tetrahedron Letters, vol.47, issue.45, pp.7969-7972, 2006.
DOI : 10.1016/j.tetlet.2006.08.111

M. Teulade and P. Savignac, Carbanions phosphonates ??-lithi??s: synth??se, basicit?? compar??e et stabilit?? ?? l'autocondensation, Journal of Organometallic Chemistry, vol.312, issue.3, pp.283-295, 1986.
DOI : 10.1016/0022-328X(86)80314-X

M. H. Stowell, J. F. Witte, and R. W. Mcclard, The phosphonylphosphinyl dianion: A convenient synthon for the preparation of biologically interesting phosphonylphosphinyl (P-C-P-C) compounds, Tetrahedron Letters, vol.30, issue.4, pp.411-414, 1989.
DOI : 10.1016/S0040-4039(00)95214-6

P. Bisseret and J. Eustache, H-Phosphonylphosphonate triethylester: the first member of a novel family of stable bisphosphorylated compounds; its short synthesis and reactivity with aldehydes, Tetrahedron Letters, vol.42, issue.48, pp.8451-8453, 2001.
DOI : 10.1016/S0040-4039(01)01798-1

J. G. Cannon and D. L. Koble, Derivatives of 5-hydroxy-6-methyl-2-aminotetralin, Journal of Medicinal Chemistry, vol.23, issue.7, pp.750-754, 1980.
DOI : 10.1021/jm00181a010

J. Frith, J. Monkkonen, S. Auriola, H. Monkkonen, and M. Rogers, The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis, Arthritis & Rheumatism, vol.172, issue.9, pp.2201-2210, 2001.
DOI : 10.1002/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E

Y. Ling, G. Sahota, O. Sarah, J. M. Chan, F. G. Araujo et al., QSAR, and In Vivo Investigations, Journal of Medicinal Chemistry, vol.48, issue.9, pp.3130-3140, 2005.
DOI : 10.1021/jm040132t

S. Gosh, J. M. Chan, C. R. Lea, G. A. Meints, J. C. Lewis et al., Species in Vitro and in Vivo, Journal of Medicinal Chemistry, vol.47, issue.1, pp.175-187, 2004.
DOI : 10.1021/jm030084x

S. Szajnman, A. Montalvetti, Y. Wang, R. Docampo, and J. Rodriguez, Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.19, pp.3231-3235, 2003.
DOI : 10.1016/S0960-894X(03)00663-2

A. Montalvetti, B. Bailey, M. Martin, G. Severin, E. Oldfield et al., Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase, Journal of Biological Chemistry, vol.276, issue.36, pp.33930-33937, 2001.
DOI : 10.1074/jbc.M103950200

S. Ghosh, J. Chan, C. Lea, G. Meints, J. Lewis et al., Species in Vitro and in Vivo, Journal of Medicinal Chemistry, vol.47, issue.1, pp.175-187, 2004.
DOI : 10.1021/jm030084x

M. Glenn, S. Chang, C. Horney, K. Rivas, K. Yokoyama et al., Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites, Journal of Medicinal Chemistry, vol.49, issue.19, pp.5710-5727, 2006.
DOI : 10.1021/jm060081v

P. Ducy, T. Schinke, and G. Karsenty, The Osteoblast: A Sophisticated Fibroblast under Central Surveillance, Science, vol.289, issue.5484, pp.1501-1504, 2000.
DOI : 10.1126/science.289.5484.1501

D. Shevrin, K. Gorny, T. Rosol, and S. Kukreja, Effect of etidronate disodium on the development of bone lesions in an animal model of bone metastasis using the human prostate cancer cell line PC-3, The Prostate, vol.10, issue.2, pp.149-154, 1991.
DOI : 10.1002/pros.2990190208

M. Pollard, P. Luckert, and J. , Effects of Dichloromethylene Diphosphonate on the Osteolytic and Osteoplastic Effects of Rat Prostate Adenocarcinoma Cells2, JNCI: Journal of the National Cancer Institute, vol.75, issue.5, pp.949-954, 1985.
DOI : 10.1093/jnci/75.5.949

F. Wingen, . Eichmannt, C. Manegold, and K. B. , Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat, Journal of Cancer Research and Clinical Oncology, vol.23, issue.II, pp.35-41, 1986.
DOI : 10.1007/BF00402773

R. Nemoto, Y. Nishijima, K. Uchida, and K. Koiso, Inhibition by a new bisphosphonate (YM175) of bone resorption induced by the MBT-2 tumour of mice, British Journal of Cancer, vol.67, issue.5, pp.893-897, 1993.
DOI : 10.1038/bjc.1993.167

T. Yoneda, A. Sasaki, C. Dunstan, P. Williams, F. Bauss et al., Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2., Journal of Clinical Investigation, vol.99, issue.10, pp.2509-2517, 1997.
DOI : 10.1172/JCI119435

C. Denoyelle, L. Hong, J. Vannier, J. Soria, and C. Soria, New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects, British Journal of Cancer, vol.88, issue.10, pp.1631-1640, 2003.
DOI : 10.1038/sj.bjc.6600925

Y. Hamma-kourbali, D. Bnedtto, M. Ledoux, D. Oudar, O. Leroux et al., A novel non-containing-nitrogen bisphosphonate inhibits both in vitro and in vivo angiogenesis, Biochemical and Biophysical Research Communications, vol.310, issue.3, pp.816-823, 2003.
DOI : 10.1016/j.bbrc.2003.09.083

V. Kunzmann, M. Bauer, M. Wilhelm, and N. , ??/?? T-Cell Stimulation by Pamidronate, New England Journal of Medicine, vol.340, issue.9, pp.737-738, 1999.
DOI : 10.1056/NEJM199903043400914

H. Das, L. Wang, A. Kamath, and J. F. Bukowski, Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates, Blood, vol.98, issue.5, pp.1616-1618, 2001.
DOI : 10.1182/blood.V98.5.1616

A. Märten, V. Lilienfeld-toal, M. W. Büchler, and J. Schmidt, Zoledronic Acid has Direct Antiproliferative and Antimetastatic Effect on Pancreatic Carcinoma Cells and Acts as an Antigen for ??2 ??/?? T Cells, Journal of Immunotherapy, vol.30, issue.4, pp.370-377, 2007.
DOI : 10.1097/CJI.0b013e31802bff16

Y. Kato, Y. Tanaka, and F. Miyagawa, Targeting of Tumor Cells for Human ???? T Cells by Nonpeptide Antigens, The Journal of Immunology, vol.167, issue.9, pp.5092-5098, 2001.
DOI : 10.4049/jimmunol.167.9.5092

S. Jagdev, R. Coleman, C. Shipman, A. Rostami, and P. Croucher, The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel, British Journal of Cancer, vol.84, issue.8, pp.1126-1134, 2001.
DOI : 10.1054/bjoc.2001.1727

Y. Zhang, A. Leon, Y. Song, Y. Studer, C. Haase et al., Activity of Nitrogen-Containing and Non-Nitrogen-Containing Bisphosphonates on Tumor Cell Lines, Journal of Medicinal Chemistry, vol.49, issue.19, pp.5804-5814, 2006.
DOI : 10.1021/jm060280e

Y. G. Golobov and L. F. Kashukin, Recent advances in the staudinger reaction, Tetrahedron, vol.48, issue.8, pp.1353-1406, 1992.
DOI : 10.1016/S0040-4020(01)92229-X

M. Miura, Rational Ligand Design in Constructing Efficient Catalyst Systems for Suzuki???Miyaura Coupling, Angewandte Chemie International Edition, vol.43, issue.17, pp.2201-2203, 2004.
DOI : 10.1002/anie.200301753

M. Rauhut, H. Currier, A. B. Us-patent-baylis, M. E. Hillman, G. Patent-rafel et al., 155 a), J.Org.Chem, vol.155113, issue.62, pp.999-1521, 1963.

D. Ma, X. Lu, and Y. Yu, Highly stereoselective isomerization of ynones to conjugated dienones catalyzed by transition-metal complexes, The Journal of Organic Chemistry, vol.54, issue.5, pp.1105-1109, 1989.
DOI : 10.1021/jo00266a021

B. M. Trost and U. Kazmaier, Internal redox catalyzed by triphenylphosphine, Journal of the American Chemical Society, vol.114, issue.20, pp.7933-7935, 1992.
DOI : 10.1021/ja00046a062

B. M. Trost, C. J. Li, J. Am-alvarez-ibarra, C. Csaky, A. G. De-la-oliva et al., Novel "Umpolung" in C-C Bond Formation Catalyzed by Triphenylphosphine, Journal of the American Chemical Society, vol.116, issue.7, pp.3167-3168, 1994.
DOI : 10.1021/ja00086a074

B. M. Trost and G. R. Dake, Nitrogen Pronucleophiles in the Phosphine-Catalyzed ??-Addition Reaction, The Journal of Organic Chemistry, vol.62, issue.17, pp.5670-5671, 1997.
DOI : 10.1021/jo970848e

B. M. Trost, C. J. Li, and J. , Novel "Umpolung" in C-C Bond Formation Catalyzed by Triphenylphosphine, Journal of the American Chemical Society, vol.116, issue.7, pp.3167-3168, 1994.
DOI : 10.1021/ja00086a074

B. M. Trost and G. R. Dake, Nucleophilic ??-Addition to Alkynoates. A Synthesis of Dehydroamino Acids, Journal of the American Chemical Society, vol.119, issue.32, pp.7595-7596, 1997.
DOI : 10.1021/ja971238z

S. Meunier, J. Siaugue, M. Sawicki, F. Calbour, S. Dézard et al., Modular Liquid-Phase Parallel Synthesis of a Highly Diverse Ligand Library, Journal of Combinatorial Chemistry, vol.5, issue.3, pp.201-204, 2003.
DOI : 10.1021/cc0200991

URL : https://hal.archives-ouvertes.fr/hal-00168475

M. Hanédanian, O. Loreau, M. Sawicki, and F. Taran, Tributylphosphine as a superior catalyst for the ??-C-addition of 1,3-dicarbonyl compounds to electron-deficient alkynes, Tetrahedron, vol.61, issue.9, pp.2287-2294, 2005.
DOI : 10.1016/j.tet.2005.01.038

R. Dizière and P. Savignac, A new simple method for the synthesis of 1-alkynylphosphonates using (EtO)2P(O)CCl3 as precursor, Tetrahedron Letters, vol.37, issue.11, pp.1783-1786, 1996.
DOI : 10.1016/0040-4039(96)00131-1

S. G. Dutremez, C. Guerin, B. J. Henner, and V. Tomberli, DIETHYL ETHYNYLPHOSPHONATE: A VERSATILE SYNTHON FOR THE PREPARATION OF 1-ALKYNYL- AND 1,3-BUTADIY NE-1,4-DIYLPHOSPHONATES, Phosphorus, Sulfur, and Silicon and the Related Elements, vol.36, issue.1, pp.251-269, 2002.
DOI : 10.1021/ja01070a014

A. Klapars and S. L. Buchwald, Copper-Catalyzed Halogen Exchange in Aryl Halides:?? An Aromatic Finkelstein Reaction, Journal of the American Chemical Society, vol.124, issue.50, pp.14844-14845, 2002.
DOI : 10.1021/ja028865v

M. Ijsselstijn and J. C. Cintrat, Click chemistry with ynamides, Tetrahedron, vol.62, issue.16, pp.3837-3842, 2006.
DOI : 10.1016/j.tet.2005.11.090

J. M. Rondeau, F. Bitsch, E. Bourgier, M. Geiser, R. Hemmig et al., Structural Basis for the Exceptional in???vivo Efficacy of Bisphosphonate Drugs, ChemMedChem, vol.47, issue.2, pp.267-273, 2006.
DOI : 10.1002/cmdc.200500059

N. Furukawa, T. Yoshimura, M. Ohtsu, T. Akasaka, and S. Oae, One step synthesis of aziridines by the Michael type addition of free sulfimides, Tetrahedron, vol.36, issue.1, pp.73-80, 1980.
DOI : 10.1016/0040-4020(80)85027-7

I. Klement, M. Rottlânder, C. E. Tucker, T. N. Majid, and P. Knochel, Preparation of polyfunctional aryl and alkenyl zinc halides from functionalized unsaturated organolithiums and their reactivity in cross-coupling and conjugated addition reactions, Tetrahedron, vol.52, issue.21, pp.7201-7220, 1996.
DOI : 10.1016/0040-4020(96)00246-3

D. Lecerclé, M. Sawicki, and F. Taran, -Addition on Activated Alkynes: A New Route to P???C???P Backbones, Organic Letters, vol.8, issue.19, pp.4283-4285, 2006.
DOI : 10.1021/ol061589v

J. J. Vepsäläinen, Bisphosphonate Prodrugs, Current Medicinal Chemistry, vol.9, issue.12, pp.1201-1208, 2002.
DOI : 10.2174/0929867023369998

L. Wang, Z. Yang, J. Gao, K. Xu, H. Gu et al., A Biocompatible Method of Decorporation:?? Bisphosphonate-Modified Magnetite Nanoparticles to Remove Uranyl Ions from Blood, Journal of the American Chemical Society, vol.128, issue.41, pp.13358-13359, 2006.
DOI : 10.1021/ja0651355

H. Chen, M. Kaminski, X. Liu, C. Mertz, Y. Xie et al., A novel human detoxification system based on nanoscale bioengineering and magnetic separation techniques, Medical Hypotheses, vol.68, issue.5, pp.1071-1079, 2007.
DOI : 10.1016/j.mehy.2005.04.047

H. Partie-expérimentale, CDCl 3 , 400 MHz) : Z : ? 0,94 (t, J=7Hz, 3H), p.9638

J. Mhzdd, (d, J=13.7Hz); 128,95; 130,71; 131.51; 131.62, MHz) : Z: ? 12, pp.7534438611780881069552657764-31, 1940.

. Mhz, J=6,5Hz)10 (d, J=6,6Hz), MHz) : ? 12.38 (d, J=54.6Hz, 1P), pp.92242744172942245042-31, 0160.

H. Nmr, CDCl 3 ) (? ppm) : 1.30(t, J=7.2Hz, 6H k ), MHz, vol.1, p.31

C. Nmr-j=3hz and C. , 33(d, J=3Hz,C k )39(d, J=3Hz,C k ), C j, vol.10087, issue.63, pp.16-30