Skip to Main content Skip to Navigation
Theses

Motricité, cognition, émotion dans la maladie de Parkinson : rôle des oscillations du noyau subthalamique

Abstract : Deep brain stimulation may be used to study the oscillatory activity of the subthalamic nucleus (STN) local field potentials in Parkinson's disease (PD) patients. The aim of this study was to characterize the STN oscillatory activity during voluntary movements, executive functions and emotion perception. Our results show that akinesia is associated and correlated with beta band hypersynchronization recorded in the dorsolateral part of the STN. The beta band oscillatory activity differs within decision making, inhibition and movement preparation functions. The default of emotion perception is associated with a lack of alpha band synchronisation in OFF dopaminergic medication condition. Levodopa modulates, at least partly, the oscillatory activities of the motor, executive and emotional basal ganglia functional pathways. The alpha, beta and gamma oscillatory activities are balanced in the normal functioning of the neuronal networks.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-00358139
Contributor : Valérie Fraix <>
Submitted on : Monday, February 2, 2009 - 7:38:15 PM
Last modification on : Thursday, May 20, 2021 - 4:50:02 PM
Long-term archiving on: : Tuesday, June 8, 2010 - 6:39:11 PM

Identifiers

  • HAL Id : tel-00358139, version 1

Collections

INSERM | U836 | UJF | UGA

Citation

Valérie Fraix. Motricité, cognition, émotion dans la maladie de Parkinson : rôle des oscillations du noyau subthalamique. Neurosciences [q-bio.NC]. Université Joseph-Fourier - Grenoble I, 2008. Français. ⟨tel-00358139⟩

Share

Metrics

Record views

721

Files downloads

4608