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Test de type-log rank pour l'évolution de la qualité de vie liée à la santé

Abstract : Longitudinal epidemiological studies on health related quality of life (HrQoL) had a significant development these last years in particular for chronic diseases, where no perspective of definitive cure exists. So, the main goal of such studies is an epidemiological surveillance of health, including HrQoL and survival. Such surveillance is mainly based on comparison of longitudinal evolution of the HrQoL between groups of patients. To that end and when the number of groups is two, we propose a global log-rank statistical test built on the HrQoL rate of degradation.
Usually, in longitudinal clinical studies, patients are asked to fill out HrQoL questionnaires on fixed dates, so it's possible to evaluate their HrQoL. The amount of degradation of HrQoL reflects HrQoL evolution in comparison with an initial date (baseline). A threshold x can be chosen to define maximum acceptable degradation of HrQoL. So, patients are considered as degraded at time t if degradation of HrQoL is higher than x. We generalized the partial likelihood score statistic in order to take into account the event of interest degradation of HrQoL for a fixed rate x. We proved that the normalized vector score process converges to a mean zero variate Gaussian process. Then we supposed that the rate of degradation of HrQoL x, is varying. By using empirical process theory we obtained that the normalized vector score process converges in distribution to a Gaussian process. These results entitled to develop a global nonparametric statistical test in order to compare rate of degradation of HrQoL between two groups of patients.
Simulations and an application to a Cohort of HIV- infected patients were discussed.
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https://tel.archives-ouvertes.fr/tel-00356750
Contributor : Véronique Boisson <>
Submitted on : Wednesday, January 28, 2009 - 3:13:20 PM
Last modification on : Monday, December 14, 2020 - 9:46:47 AM
Long-term archiving on: : Tuesday, June 8, 2010 - 6:58:16 PM

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  • HAL Id : tel-00356750, version 1

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Véronique Boisson. Test de type-log rank pour l'évolution de la qualité de vie liée à la santé. Sciences du Vivant [q-bio]. Université Pierre et Marie Curie - Paris VI, 2008. Français. ⟨tel-00356750⟩

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