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Etude structurale de PBP3 et localisation des six « Penicillin-Binding Proteins » de Streptococcus pneumoniae : implication dans la croissance et la division bactérienne.

Abstract : The aim of my thesis project was to study the pneumococcal cell wall synthesis, which participates to the bacterial growth and division and involves the « Penicillin-Binding Proteins » (PBPs). I performed the localisation of the complete PBP family from the human pathogen S. pneumoniae during the cell cycle, which revealed unexpected similarities between the mechanism of cell division in bacilli and cocci. The identification of the specific role of each PBP enlightened the contribution of the D,D-carboxypeptidase PBP3 in the regulation of the bacterial division. I also solved the three-dimensional structure of PBP3 to 2.8 Å resolution, which allowed me to constrain the pneumococcal cell wall synthesis models.
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https://tel.archives-ouvertes.fr/tel-00349752
Contributor : Cecile Morlot <>
Submitted on : Sunday, January 4, 2009 - 4:03:45 AM
Last modification on : Tuesday, October 6, 2020 - 4:12:03 PM
Long-term archiving on: : Thursday, October 11, 2012 - 3:01:28 PM

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  • HAL Id : tel-00349752, version 1

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Cécile Morlot. Etude structurale de PBP3 et localisation des six « Penicillin-Binding Proteins » de Streptococcus pneumoniae : implication dans la croissance et la division bactérienne.. Sciences du Vivant [q-bio]. Université Joseph-Fourier - Grenoble I, 2003. Français. ⟨tel-00349752⟩

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