Etude in vivo de la dégénérescence discale par IRM à 9,4 T: application à la validation de méthodes de réparation discale chez le lapin

Abstract : In our society, back pain is a common pathology representing an important health problem in cost and constantly increasing.
It is now widely accepted that the intervertebral disc (IVD) degeneration is the leading cause of back pain. This degeneration is a complex process characterized by structural and biochemical changes occurring in various tissues of the DIV.
Today, only symptomatic treatments of back pain are available and there is no specific treatment for disc degeneration.
Magnetic resonance imaging (MRI) is known as a non-invasive and completely non-traumatic technique of diagnosis in humans. MRI can characterize the morphology and physiology of a living from changes in the status of water in its tissues.
Due to the composition of the IVD (mainly water) MRI is proving to be particularly suited to the study of healthy or degenerative IVD, and his regeneration under the evaluation of the effectiveness of a treatment.
The objectives of this project were first to develop an in vivo MRI protocol of the IVD, in rabbit, able to differentiate healthy and pathological IVD and highlight various stages of disc degeneration. This protocol was then used to assess the effectiveness of new IVD repair techniques developed by the Abbott Spine company.
In parallel with this work in rabbit, in vivo MRI of mice IVD has been developed in order to use genetically modified mice models of articular diseases and study their impact on IVD.
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Fanny Noury. Etude in vivo de la dégénérescence discale par IRM à 9,4 T: application à la validation de méthodes de réparation discale chez le lapin. Biophysique [physics.bio-ph]. Université d'Orléans, 2008. Français. ⟨tel-00347842⟩

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