Modulations envisagées sur l'adénine avant réaction avec, Schéma, vol.4, p.80 ,
Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating, Pfl???gers Archiv - European Journal of Physiology, vol.274, issue.1, 2004. ,
DOI : 10.1007/s00424-004-1317-y
Capsaicin Potentiates Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Currents, Molecular Pharmacology, vol.65, issue.6, p.1415, 2004. ,
DOI : 10.1124/mol.65.6.1415
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283138/pdf
Diaminopurine-acridine heterodimers for specific recognition of abasic site containing DNA, Influence on the biological activity of the position of the linker on the purine ring, 1855. ,
Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis, Trends in Pharmacological Sciences, vol.28, issue.7, p.334, 2007. ,
DOI : 10.1016/j.tips.2007.05.004
Potent inhibition of the CFTR chloride channel by suramin, Naunyn-Schmiedebergs Archives of Pharmacology 360, p.473, 1999. ,
On the Discovery and Development of CFTR Chloride Channel Activators, Current Pharmaceutical Design, vol.12, issue.4, p.471, 2006. ,
DOI : 10.2174/138161206775474459
Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel, Journal of Biological Chemistry, vol.274, p.27415, 1999. ,
Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line, Nature Medicine, vol.3, 1280. ,
Curcumin Stimulates Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel Activity, Journal of Biological Chemistry, vol.280, issue.7, p.5221, 2005. ,
DOI : 10.1074/jbc.M412972200
Salivary secretion assay for drug efficacy for cystic fibrosis in mice, Experimental Physiology, vol.286, issue.Suppl. 1, 2005. ,
DOI : 10.1152/ajpcell.00397.2003
Biochemistry and molecular cell biology of diabetic complications, Nature, vol.414, issue.6865, 2001. ,
DOI : 10.1038/414813a
by the aminoglycoside anthiotics G???418 and paromomycin, Nucleic Acids Research, vol.13, issue.17, p.6265, 1985. ,
DOI : 10.1093/nar/13.17.6265
CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.285, issue.1, p.180, 2003. ,
DOI : 10.1152/ajplung.00351.2002
Pharmacology of the CFTR Cl- Channel, 2003. ,
Strategies to investigate the mechanism of action of CFTR modulators, Journal of Cystic Fibrosis, vol.3, p.141, 2004. ,
DOI : 10.1016/j.jcf.2004.05.030
Evidence that Systemic Gentamicin Suppresses Premature Stop Mutations in Patients with Cystic Fibrosis, American Journal of Respiratory and Critical Care Medicine, vol.163, issue.7, p.1683, 2001. ,
DOI : 10.1164/ajrccm.163.7.2004001
ClC-2Cl(-) channels in human lung epithelia: activation by arachidonic acid, amidation, and acidactivated omeprazole, American Journal of Physiology-Cell Physiology, vol.281, p.46, 2001. ,
Some like it hot: curcumin and CFTR, Trends in Molecular Medicine 10, 473 A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR Delta F508, Molecular Medicine, vol.8, p.75, 2002. ,
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive, Nature, vol.358, issue.6389, p.761, 1992. ,
DOI : 10.1038/358761a0
Imidazolopyrazinones as potential antioxidants, Bioorganic & Medicinal Chemistry Letters, vol.11, issue.17, 2001. ,
DOI : 10.1016/S0960-894X(01)00445-0
Block of CFTR-dependent chloride currents by inhibitors of multidrug resistanceassociated proteins, European Journal of Pharmacology, vol.560, issue.127, 2007. ,
Intestinal ion transport and the pathophysiology of diarrhea, Journal of Clinical Investigation, vol.111, issue.7, p.931, 2003. ,
DOI : 10.1172/JCI18326DS1
A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells, Journal of Ethnopharmacology, vol.93, issue.2-3, p.351, 2004. ,
DOI : 10.1016/j.jep.2004.04.005
Statedependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin, Journal of Biological Chemistry, vol.282, p.37545, 2007. ,
Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model, Science, vol.266, issue.5182, 1994. ,
DOI : 10.1126/science.7524148
A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.276, p.58, 1999. ,
Highly Diastereoselective Synthesis of C(6)-Functionalized Dihydroimidazotriazines, Organic Letters, vol.5, issue.24, p.4595, 2003. ,
DOI : 10.1021/ol035743e
Adenine-based receptor for dicarboxylic acids, Tetrahedron Letters, vol.48, issue.39, p.7022, 2007. ,
DOI : 10.1016/j.tetlet.2007.07.110
In vivo assessment of toxicity and pharmacokinetics of methylglyoxal, Toxicology and Applied Pharmacology, vol.212, issue.1, p.45, 2006. ,
DOI : 10.1016/j.taap.2005.07.003
Model Reactions on Roast Aroma Formation. 15. Investigations on the Formation of Pyrido[3,4-d]imidazoles during the Maillard Reactions, Model Reactions on Roast Aroma Formation. 15. Investigations on the Formation of Pyrido[3,4-d]imidazoles during the Maillard Reactions, p.2226, 1995. ,
DOI : 10.1021/jf00056a048
Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl-channels in rat epididymal epithelial cells, Biology of Reproduction, vol.67, 1888. ,
Revisiting Cystic Fibrosis Transmembrane Conductance Regulator Structure and Function, Proceedings of the American Thoracic Society, vol.1, issue.1, p.17, 2004. ,
DOI : 10.1513/pats.2306009
URL : http://doi.org/10.1513/pats.2306009
Natural compound curcumin corrects the gating defect of G551Dmutant cystic fibrosis transmembrane conductance regulator, Chemical Research in Chinese Universities, vol.24, p.92, 2008. ,
A class of high-affinity bicyclooctane G551D-CFTR activators identified by high throughput screening, Chemical Research in Chinese Universities, vol.20, p.743, 2004. ,
Active Intestinal Chloride Secretion in Human Carriers of Cystic Fibrosis Mutations: An Evaluation of the Hypothesis That Heterozygotes Have Subnormal Active Intestinal Chloride Secretion, The American Journal of Human Genetics, vol.67, issue.6, p.1422, 2000. ,
DOI : 10.1086/316911
Synthesis of new mono- and disubstituted hydroxyalkyl and aminoalkyl derivatives of heterocyclic bases, Collection of Czechoslovak Chemical Communications, vol.43, issue.12, p.3444, 1978. ,
DOI : 10.1135/cccc19783444
[(Dihydroindenyl)oxy]alkaonic acid inhibits the cystic fibrosis transmembrane conductance regulator, European Journal of Pharmacology, vol.426, issue.3, p.175, 2001. ,
DOI : 10.1016/S0014-2999(01)01106-2
A New Catalytic C???C Bond-Forming Hydrogenation: Reductive Coupling of Dienes and Glyoxals under Catalytic Hydrogenation Conditions, Angewandte Chemie International Edition, vol.42, issue.34, p.4074, 2003. ,
DOI : 10.1002/anie.200351986
Hydrogen-Mediated C???C Bond Formation:?? Catalytic Regio- and Stereoselective Reductive Condensation of ??-Keto Aldehydes and 1,3-Enynes, Journal of the American Chemical Society, vol.126, issue.14, p.4664, 2004. ,
DOI : 10.1021/ja0316566
Activation of CFTR-mediated Cl??? Transport by Magnolin, Chinese Universities 24, 2008. ,
DOI : 10.1016/S1005-9040(08)60038-0
Methylglyoxal in living organisms, Toxicology Letters, vol.110, issue.3, p.145, 1999. ,
DOI : 10.1016/S0378-4274(99)00160-5
Mutation specific therapy in CF, Paediatric Respiratory Reviews, vol.7, p.166, 2006. ,
DOI : 10.1016/j.prrv.2006.04.213
Cystic Fibrosis Transmembrane Conductance Regulator-dependent Up-regulation of Kir1.1 (ROMK) Renal K+ Channels by the Epithelial Sodium Channel, Journal of Biological Chemistry, vol.277, issue.28, p.25377, 2002. ,
DOI : 10.1074/jbc.M201925200
An efficient synthesis of acyclic N-7-and N-9-adenine nucleosides via alkylation with secondary carbon electrophiles to introduce versatile functional groups at the C-1 position of acyclic moiety, Nucleosides Nucleotides & Nucleic Acids, vol.25, issue.121, 2006. ,
Chemiluminescence method for the determination of adenine after reaction with phenylglyoxal, Analytica Chimica Acta, vol.278, issue.2, p.275, 1993. ,
DOI : 10.1016/0003-2670(93)85110-6
Nucleoside modifies et lesions de l'ADN -mise au point d'une nouvelle methode de synthese d'oligonucleotides a site abasique, 1992. ,
Hydrolysis of 2???-deoxypurine nucleosides. The effect of substitution at the C-8 position, Tetrahedron Letters, vol.35, issue.28, p.4989, 1994. ,
DOI : 10.1016/S0040-4039(00)73300-4
Induction by antitumoral drugs of proteins that functionally complement CFTR: a novel therapy for cystic fibrosis?, The Lancet, vol.350, issue.9079, p.711, 1997. ,
DOI : 10.1016/S0140-6736(05)63510-6
URL : https://hal.archives-ouvertes.fr/hal-00772899
New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile, Purinergic Signalling, vol.3, p.339, 2007. ,
Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides, Nucleosides, Nucleotides & Nucleic Acids, vol.20, 1949. ,
The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2???-deoxyguanosine, Analytical and Bioanalytical Chemistry, vol.386, issue.2, p.679, 2008. ,
DOI : 10.1007/s00216-007-1682-4
Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acid, Canadian Journal of Physiology and Pharmacology, vol.78, issue.6, p.490, 2000. ,
DOI : 10.1139/y00-014
Structure and Function of ABC Transporters, Physiology, vol.22, issue.2, 2007. ,
DOI : 10.1152/physiol.00046.2006
Natural compound 20(S)protopanaxadiol activates cystic fibrosis transmembrane conductance regulator chloride channel, Chemical Journal of Chinese Universities-Chinese, vol.29, p.731, 2008. ,
Oxidation of a-methyl or a-methylene groups in carbonyl compounds with ammonium chlorochromate, Chinese Chemical Letters, vol.3, p.585, 1992. ,
Expression of CFTR controls cAMP-dependent activation of epithelial K+ currents, American Journal of Physiology-Cell Physiology, vol.40, p.1565, 1996. ,
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin???induced intestinal fluid secretion, Journal of Clinical Investigation, vol.110, issue.11, p.1651, 2002. ,
DOI : 10.1172/JCI0216112
High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening, Journal of Biological Chemistry, vol.277, issue.40, p.37235, 2002. ,
DOI : 10.1074/jbc.M205932200
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways., Journal of Clinical Investigation, vol.102, issue.1, p.15, 1998. ,
DOI : 10.1172/JCI2729
General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels, British Journal of Pharmacology, vol.600, issue.6, p.905, 2004. ,
DOI : 10.1038/sj.bjp.0705684
URL : https://hal.archives-ouvertes.fr/hal-00143529
Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels, Journal of Medicinal Chemistry, vol.47, p.962, 2004. ,
Method for the Synthesis of Uric Acid Derivatives, Nucleosides, Nucleotides and Nucleic Acids, vol.195, issue.7, 1193. ,
DOI : 10.1039/jr9550000211
The role of dicarbonyl compounds in nonenzymatic crosslinking: a structure-activity study, Bioorg Med Chem, vol.11, issue.853, 2003. ,
Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces, Cellular and Molecular Life Sciences, vol.65, issue.16, p.2594, 2008. ,
DOI : 10.1007/s00018-008-8249-1
URL : https://hal.archives-ouvertes.fr/hal-00288535
The Origin of the Major Cystic-Fibrosis Mutation (Delta-F508) in European Populations, Nature Genetics, vol.7, p.169, 1994. ,
Identification of New Small Molecule Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator Protein: In Vitro and in Vivo Studies, Biological & Pharmaceutical Bulletin, vol.30, issue.3, p.502, 2007. ,
DOI : 10.1248/bpb.30.502
Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors, The Journal of General Physiology, vol.95, issue.2, p.125, 2004. ,
DOI : 10.1085/jgp.20028685
Spectroscopic studies of methylglyoxal in water and dimethylsulfoxide, Bioorganic Chemistry, vol.32, issue.6, p.560, 2004. ,
DOI : 10.1016/j.bioorg.2004.05.008
Synthesis of Linear and Tripoidal Oligo(phenyleneethynylene)-Based Building Blocks for Application in Modular DNA-Programmed Assembly, Journal of Organic Chemistry, vol.69, 2004. ,
Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation, 1071. ,
Discovery of Pyrrolo[2,3-b]pyrazines Derivatives as Submicromolar Affinity Activators of Wild Type, G551D, and F508del Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels, Journal of Pharmacology and Experimental Therapeutics, vol.319, issue.1, p.349, 2006. ,
DOI : 10.1124/jpet.106.104521
Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alphaglucosidase inhibitor miglustat, Febs Letters, vol.580, 2006. ,
Chemiluminescence Derivatization of Methylglyoxal Using 2-Aminonicotinic Acid., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.48, issue.8, 1236. ,
DOI : 10.1248/cpb.48.1236
Methylglyoxal Modification of Protein: CHEMICAL AND IMMUNOCHEMICAL CHARACTERIZATION OF METHYLGLYOXAL-ARGININE ADDUCTS, Journal of Biological Chemistry, vol.274, issue.26, p.18492, 1999. ,
DOI : 10.1074/jbc.274.26.18492
A Natural Plant-Derived Dihydroisosteviol Prevents Cholera Toxin-Induced Intestinal Fluid Secretion, Journal of Pharmacology and Experimental Therapeutics, vol.324, issue.2, p.798, 2008. ,
DOI : 10.1124/jpet.107.129288
Structure-Activity Relationship of 1,4-Dihydropyridines as Potentiators of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel, Molecular Pharmacology, vol.72, issue.1, 0197. ,
DOI : 10.1124/mol.107.034702
Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations, Molecular Pharmacology, vol.68, p.1736, 2005. ,
Phenylglycine and Sulfonamide Correctors of Defective ??F508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating, Molecular Pharmacology, vol.67, issue.5, p.1797, 2005. ,
DOI : 10.1124/mol.105.010959
aryloxyethyl) derivatives of adenine -a new class of non-nucleosidic antiviral agents, Chemistry of Heterocyclic Compounds, issue.92, 2003. ,
Evaluating candidate agents of selective pressure for cystic fibrosis, Journal of The Royal Society Interface, vol.4, issue.12, p.91, 2007. ,
DOI : 10.1098/rsif.2006.0154
New: liquid-process sodium silicate, Chem. Eng, vol.69, p.76, 1962. ,
Urea cycle: chemical simulation of arginine biosynthesis, The Journal of Organic Chemistry, vol.55, issue.8, p.2351, 1990. ,
DOI : 10.1021/jo00295a022
Heterocyclic ambident nucleophiles. III. The alkylation of sodium adenide, Australian Journal of Chemistry, vol.35, issue.3, p.525, 1982. ,
DOI : 10.1071/CH9820525
ASSEMBLY OF FUNCTIONAL CFTR CHLORIDE CHANNELS, Annual Review of Physiology, vol.67, issue.1, p.701, 2005. ,
DOI : 10.1146/annurev.physiol.67.032003.154107
CFTR Function and Prospects for Therapy, Annual Review of Biochemistry, vol.77, issue.1, p.701, 2008. ,
DOI : 10.1146/annurev.biochem.75.103004.142532
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA, Science, vol.245, 1066. ,
La Mucoviscidose, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-00690789
Nouvelle réaction du méthylglyoxal avec des bases nucléiques et des composés apparentés. Accès à de nouvelles familles d'hétérocycles, 2003. ,
New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: Formation of imino acid-nucleic base derivatives in water under mild conditions, Chemical Communications, 1114. ,
Discovery of alpha-aminoazaheterocyclemethylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels, Journal of Pharmacology and Experimental Therapeutics, vol.322, 1023. ,
The Phenotypic Consequences of CFTR Mutations, Annals of Human Genetics, vol.10, issue.5, p.471, 2003. ,
DOI : 10.1146/annurev.genet.29.1.777
benzyloxyphenyl)isoxazoles and isoxazolines: Synthesis and evaluation as CFTR activators, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.32, 2003. ,
Regulation of CFTR Cl- channel gating by ADP and ATP analogues, Regulation of Cftr Cl-Channel Gating by Adp and Atp Analogs, p.329, 1995. ,
DOI : 10.1085/jgp.105.3.329
CFTR is a conductance regulator as well as a chloride channel, Physiol Rev, vol.79, p.145, 1999. ,
Interest of Colchicine for the Treatment of Cystic Fibrosis Patients. Preliminary Report, Mediators of Inflammation, vol.8, issue.1, p.13, 1999. ,
DOI : 10.1080/09629359990667
CFTR channel pharmacology: Novel pore blockers identified by highthroughput screening, Journal of General Physiology, vol.124, issue.109, 2004. ,
DOI : 10.1085/jgp.200409135
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229622
Structure and function of the CFTR chloride channel, Physiol Rev, vol.79, p.23, 1999. ,
Stimulation of Cl-secretion by chlorzoxazone, Journal of Pharmacology and Experimental Therapeutics, vol.292, p.778, 2000. ,
One-pot synthesis of N-alkyl purine and pyrimidine derivatives from alcohols using TsIm: a rapid entry into carboacyclic nucleoside synthesis, Tetrahedron, vol.64, p.1778, 2008. ,
Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera, The FASEB Journal, vol.19, issue.130, 2005. ,
DOI : 10.1096/fj.05-4818fje
Lectin Conjugates as Potent, Nonabsorbable CFTR Inhibitors for Reducing Intestinal Fluid Secretion in Cholera, Gastroenterology, vol.132, issue.4, 1234. ,
DOI : 10.1053/j.gastro.2007.02.018
]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells, British Journal of Pharmacology, vol.278, issue.3, p.531, 2004. ,
DOI : 10.1038/sj.bjp.0705846
New drug targets for cholera therapy, Trends in Pharmacological Sciences, vol.26, issue.4, p.172, 2005. ,
DOI : 10.1016/j.tips.2005.02.003
Synthesis of Silicon Analogues of Acyclonucleotides Incorporable in Oligonucleotide Solid-Phase Synthesis, The Journal of Organic Chemistry, vol.62, issue.14, p.4635, 1997. ,
DOI : 10.1021/jo962165p
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-A role in pathogenesis and antiproliferative chemotherapy, General Pharmacology: The Vascular System, vol.27, issue.4, p.565, 1996. ,
DOI : 10.1016/0306-3623(95)02054-3
ATP-binding cassette (ABC) transporters in normal and pathological lung, Respiratory Research, vol.508, issue.1, 2005. ,
DOI : 10.1186/1465-9921-6-59
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methyl glyoxal-derived AGE, Proceedings of the National Academy of Sciences of the United States of America 99, p.949, 2002. ,
Preparation of substituted pyrazoles as modulators of ATP-binding cassette transporters, Application: WOVertex Pharmaceuticals Incorporated, vol.174, 2004. ,
The cystic fibrosis transmembrane conductance regulator: an intriguing protein with pleiotropic functions, Journal of Cystic Fibrosis, vol.1, issue.1, p.13, 2002. ,
DOI : 10.1016/S1569-1993(01)00003-0
A Simple Assay for Agonist-Regulated Cl and K-Conductances in Salt-Secreting Epithelial-Cells, American Journal of Physiology, vol.259, p.358, 1990. ,
Preparation of 1,1-Dialkoxy-2-alkanones, Synthesis, vol.1982, issue.08, 1982. ,
DOI : 10.1055/s-1982-29895
Curcumin Opens Cystic Fibrosis Transmembrane Conductance Regulator Channels by a Novel Mechanism That Requires neither ATP Binding nor Dimerization of the Nucleotide-binding Domains, Journal of Biological Chemistry, vol.282, issue.7, p.4533, 2007. ,
DOI : 10.1074/jbc.M609942200
Activating Cystic Fibrosis Transmembrane Conductance Regulator Channels with Pore Blocker Analogs, Journal of Biological Chemistry, vol.280, issue.25, p.23622, 2005. ,
DOI : 10.1074/jbc.M503118200
Molecular Mechanisms of Cftr Chloride Channel Dysfunction in Cystic-Fibrosis, Cell 73, 1251. ,
Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations, Bebok Z; Shushi L; Kerem B; Kerem E New England Journal of Medicine, vol.349, 1433. ,
The antiviral activity of SP-303, a natural polyphenolic polymer, against respiratory syncytial and parainfluenza type 3 viruses in cotton rats, Antiviral Research, vol.20, issue.2, p.145, 1993. ,
DOI : 10.1016/0166-3542(93)90004-3
Preparation for 2-oxobutanal from 1,2- butanediol, Application: CN, vol.6, p.pp, 2005. ,
Nanomolar Affinity Small Molecule Correctors of Defective ??F508-CFTR Chloride Channel Gating, Journal of Biological Chemistry, vol.278, issue.37, p.35079, 2003. ,
DOI : 10.1074/jbc.M303098200
A versatile route to the synthesis of 1-substituted ??-carbolines by a single step Pictet???Spengler cyclization, Tetrahedron, vol.62, issue.47, p.10900, 2006. ,
DOI : 10.1016/j.tet.2006.08.081
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase, Journal of Medicinal Chemistry, vol.33, issue.8, 1990. ,
DOI : 10.1021/jm00170a005
Synthesis of a-dicarbonyl compounds from N-acyl-a-amino ketones, 1044. ,
Novel pharmacologic therapies for cystic fibrosis, Journal of Clinical Investigation, vol.103, issue.4, p.447, 1999. ,
DOI : 10.1172/JCI6346