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Etude du rôle et du mode d'action du proto-oncogène fli-1 dans les érythroleucémies de Friend

Abstract : FLI-1 is an ETS family transcription factor which gene is activated in murine FMuLV-induced erythroleukemias. fli-1 gene is also activated by SPI-1 / PU.1, another ETS transcription factor, which gene is activated in murine SFFV-induced erythrloleukemias. My thesis work aimed to define the FLI-1 contribution in SPI-1-induced erythroleukemias. By an unducible fli-1 knock-down, I showed that it contributes effectively to the proliferation and differentiation inhibition of spi-1 overexpressing erythroleukemic cells. A candidate gene approach and globals transcriptomes analysis, showed the FLI-1 implication in synthesis inhibition of P27KIP1 cyclin kinase inhibitor, direct transcriptionnal activation of several genes controlling rRNA synthesis and maturation, and repression of several erythrocytic genes and btg2 antiproliferative gene.
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https://tel.archives-ouvertes.fr/tel-00347366
Contributor : Gaëtan Juban <>
Submitted on : Monday, December 15, 2008 - 3:53:41 PM
Last modification on : Thursday, November 21, 2019 - 2:27:11 AM
Long-term archiving on: : Tuesday, June 8, 2010 - 4:25:31 PM

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  • HAL Id : tel-00347366, version 1

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Gaëtan Juban. Etude du rôle et du mode d'action du proto-oncogène fli-1 dans les érythroleucémies de Friend. Sciences du Vivant [q-bio]. Université Claude Bernard - Lyon I, 2008. Français. ⟨tel-00347366⟩

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