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Etude de la réplication du VHB et de la réponse à l'intracellulaire à l'infection virale

Abstract : HBV is a major problem issue since the 400 million existing chronic carriers have greater risk to develop cirrhosis or hepatocellular carcinoma. Because of the lack of relevant and convenient in vitro HBV studying model, the aim was to improve the one that uses HBV recombinant baculoviruses to deliver HBV genome in hepatocytes. Relevance of this improved system was then demonstrated for phenotypic and resistant mutant fitness analysis. Finally, with the use of HBV recombinant baculovirus in HepaRG cells, an HBV-mediated effective IFN response within cells was highlighted. This constitutes new data in the study of virus/host cell interaction since HBV was considered as a “stealth” virus until now. Taken together, these results have important implications in the comprehension HBV persistence mechanisms and in the development of new cellular models of infection.
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https://tel.archives-ouvertes.fr/tel-00342583
Contributor : Julie Lucifora <>
Submitted on : Thursday, November 27, 2008 - 4:50:29 PM
Last modification on : Friday, October 23, 2020 - 4:42:40 PM
Long-term archiving on: : Monday, June 7, 2010 - 11:31:15 PM

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  • HAL Id : tel-00342583, version 1

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Julie Lucifora. Etude de la réplication du VHB et de la réponse à l'intracellulaire à l'infection virale. Biologie cellulaire. Université Claude Bernard - Lyon I, 2008. Français. ⟨tel-00342583⟩

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