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Habilitation à diriger des recherches

Modélisation Expérimentale des Systèmes Dynamiques - Applications en Biologie Systémique

Abstract : Contributions presented in this document deal with the development of methods and tools for the experimental modeling of interconnected systems by modular representations. Contrary to black-box descriptions, the modular modeling approaches not only aim at describing the dynamical behavior of the whole system but also to depict its physical structure in terms of components and interactions. Problems associated with the experimental modeling of interconnected systems are multiple : mathematical formulation of modular representations, practical identifiability, parameter estimation and uncertainty description.

The proposed research project is concerned with the systems biology in engineering. It is focused on the experimental modeling of interconnected systems in biology and more precisely in cancerology. Two applications domains are developed : the experimental of photodynamic therapy and the identification of metabolic networks. Photodynamic therapy is an example of interconnected systems in which three system identification problems are investigated. The two final objectives are (i) to better control the reproducibility of the therapeutic outcomes and (ii) to mathematically characterize the efficacy of new photosensitizing agents. These two questions may be described as problems concerning parameter identifiability, parameter estimation and system control. Classical and modern methods of experiment design are proposed to solve these problems.
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Habilitation à diriger des recherches
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https://tel.archives-ouvertes.fr/tel-00311239
Contributor : Thierry Bastogne <>
Submitted on : Wednesday, August 13, 2008 - 3:36:05 PM
Last modification on : Friday, October 23, 2020 - 4:52:35 PM
Long-term archiving on: : Thursday, June 3, 2010 - 6:19:23 PM

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  • HAL Id : tel-00311239, version 1

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Thierry Bastogne. Modélisation Expérimentale des Systèmes Dynamiques - Applications en Biologie Systémique. Automatique / Robotique. Université Henri Poincaré - Nancy I, 2008. ⟨tel-00311239⟩

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