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Theses

Foie et tolérance périphérique
Rôle des cellules dendritiques plasmacytoides et des cellules NKT

Abstract : The liver is thought to contribute to systemic T cell tolerance, although the precise mechanism of its tolerogenic effect is unclear. This function could be particularely important to induce T cell tolerance to orally absorbed antigen circulating to the liver from the intestine via the portal vein. The aim of our study was to precise the role of the liver in peripheral tolerance and notably in oral tolerance by using a murine model of contact sensitivity to the hapten DNFB, induced by cytotoxic CD8+ effector cells. We have identified two subsets of cells enriched in the liver and involved in the regulation and tolerance of the immune response : i) the plasmacytoid dendritic cells which inhibit the CD8+ T cells response in vivo and play an important role in the induction of oral tolerance and ii) the NK-T cells able to regulate the CD8+ T cells response during the afferent and the efferent phase of the immune response.
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https://tel.archives-ouvertes.fr/tel-00305753
Contributor : Anne Goubier <>
Submitted on : Thursday, July 24, 2008 - 4:54:51 PM
Last modification on : Friday, October 23, 2020 - 4:38:07 PM
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  • HAL Id : tel-00305753, version 1

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Anne Goubier. Foie et tolérance périphérique
Rôle des cellules dendritiques plasmacytoides et des cellules NKT. Immunologie. Université Claude Bernard - Lyon I, 2006. Français. ⟨tel-00305753⟩

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