Étude et développement d'un télescope Compton au xénon liquide dédié à l'imagerie médicale fonctionnelle

Abstract : Functional imaging is a technique used to locate in three dimensions the position of a radiotracer previously injected to a patient. The two main modalities used for a clinical application to detect tumors, the SPECT and the PET, use solid scintillators as a detection medium.
The objective of this thesis was to investigate the possibility of using liquid xenon in order to benefit from the intrinsic properties of this medium in functional imaging. The feasibility study of such a device has been performed by taking into account the technical difficulties specific to the liquid xenon.
First of all, simulations of a liquid xenon PET has been performed using Monte-Carlo methods. The results obtained with a large liquid xenon volume are promising: we can expect a reduction of the injected activity of radiotracer, an improvement of the spatial resolution of the image and a parallax free camera.
The second part of the thesis was focused on the development of a new concept of medical imaging, the three gamma imaging, based on the use of a new emitter: the 44 scandium. Associated to a classical PET camera, the Compton telescope is used to infer the incoming direction of the third gamma ray by triangulation. Therefore, it is possible to reconstruct the position of each emitter in three dimensions.
This work convinced the scientific community to support the construction and characterization of a liquid xenon Compton telescope. The first camera dedicated to small animal imaging should then be operational in 2009.
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Contributor : Cyril Grignon <>
Submitted on : Wednesday, June 18, 2008 - 12:50:57 PM
Last modification on : Friday, June 22, 2018 - 9:33:35 AM
Long-term archiving on: Friday, May 28, 2010 - 8:19:30 PM

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  • HAL Id : tel-00288738, version 1

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Cyril Grignon. Étude et développement d'un télescope Compton au xénon liquide dédié à l'imagerie médicale fonctionnelle. Physique des Hautes Energies - Expérience [hep-ex]. Université de Nantes, 2007. Français. ⟨tel-00288738⟩

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