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Theses

Développement et homéostasie lymphocytaire T ab : quels rôles pour l'interleukine-7 ?

Abstract : T lymphocyte homeostasis is tightly regulated. Cytokines such as interleukin-7 (IL-7) are critically involved in regulating T cell homeostasis. During this thesis work, in order to investigate more precisely the role of IL-7 on lymphopenia-induced proliferation, we have transferred CFSE-labeled cells into novel lymphopenic IL-7 transgenic mouse lines. Results obtained indicate that T lymphocyte subsets do not respond in the same way to IL-7 homeostatic signals. We took advantage of these experiments to dissect pleiotropic effects of IL-7 on T lymphocytes. Moreover, studies of our transgenic animals also provided new insights into effects of IL-7 on early T cell development. Taken together our results indicates that increased IL-7 availability perturbs T cell homeostasis by modulating peripheral T cell proliferation and survival rather than T cell development.
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https://tel.archives-ouvertes.fr/tel-00284832
Contributor : Mohamed Nabil Bosco <>
Submitted on : Tuesday, June 3, 2008 - 5:48:40 PM
Last modification on : Friday, November 6, 2020 - 4:11:18 AM
Long-term archiving on: : Friday, May 28, 2010 - 6:52:21 PM

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  • HAL Id : tel-00284832, version 1

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Nabil Bosco. Développement et homéostasie lymphocytaire T ab : quels rôles pour l'interleukine-7 ?. Immunologie. Université Joseph-Fourier - Grenoble I, 2005. Français. ⟨tel-00284832⟩

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