Skip to Main content Skip to Navigation
Theses

Synthèse d'antigènes présentés par la protéine CD1b, analogues des sulfoglycolipides diacylés mycobactériens. Vers un nouveau vaccin contre la tuberculose.

Abstract : Recently, a new family of sulfoglycolipid antigens (Ac2SGL) presented by the CD1b protein, has been identified. It is specific of Mycobacterium tuberculosis and is able to induce the activation of cytotoxic T cells. These compounds are thought to be promising candidates for a new molecular vaccine against tuberculosis.
Owing to the scarcity of the natural product, a general synthesis of these sulfoglycolipides has been developed where the lipidic part had been replaced by a less complex one. Different polymethylated fatty acids were synthesized by stereospecific alkylation of enolates to obtain a panel of Ac2SGL analogs.
We have shown that the sructures of the two acyl chains are key structural elements that govern TCR recognition. Moreover, some synthetic sulfoglycolipids have shown similar activity to that of the natural antigen and are available in sufficient quantity to achieve further development of this family of antigens.
Document type :
Theses
Complete list of metadatas

Cited literature [95 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00282233
Contributor : Julie Guiard <>
Submitted on : Monday, May 26, 2008 - 6:36:05 PM
Last modification on : Monday, October 19, 2020 - 9:55:30 AM
Long-term archiving on: : Friday, May 28, 2010 - 8:13:04 PM

Identifiers

  • HAL Id : tel-00282233, version 1

Collections

Citation

Julie Guiard. Synthèse d'antigènes présentés par la protéine CD1b, analogues des sulfoglycolipides diacylés mycobactériens. Vers un nouveau vaccin contre la tuberculose.. Chimie. Université Paul Sabatier - Toulouse III, 2008. Français. ⟨tel-00282233⟩

Share

Metrics

Record views

239

Files downloads

1414