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Theses

Sécurisation du circuit des chimiothérapies en établissement hospitalier :application à la production des médicaments anticancéreux

Abstract : The implementation of the Cancer Plan encourage the hospital pharmacists to deal with the production of chemotherapies within the framework of units of preparation. The problems highlighted appearing with the passing of years this high-risk production for the patients and the personnel aim to the security of the whole of the circuit of chemotherapies at the hospital and in particular of the process of their production. The analysis that we led proceeded in two times : a research of the state of the art in the field of the systems then that of the risk management , then, we applied them to the field of the circuit of chemotherapies in our hospital and the definition of the matrix of criticality, the analysis of the risks relating to the scenarios of accident associated with each dangerous situation identified , the construction of the cartographies and finally the development of the catalogue of the parameters of safety. We showed a general method by initially leading the functional analysis of the system then by determining the dangerous situations . The method of risk management retained is the Preliminary Analysis of the Risks (APR) which comprises the definition of the system in terms , the development of the cartography of the dangers and the dangerous situations and then, the analysis, the evaluation and the treatment of the initial and residual risks. To implement it, we proceeded to the definition of the scales of gravity, probability, criticality, effort and the definition of the matrix of criticality, the analysis of the risks relating to the scenarios of accidents ,of the cartographies and the catalogue of the catalogue of the parameters of safety.
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https://tel.archives-ouvertes.fr/tel-00275793
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Submitted on : Friday, April 25, 2008 - 12:07:03 PM
Last modification on : Monday, October 19, 2020 - 11:08:38 AM
Long-term archiving on: : Friday, May 28, 2010 - 5:44:05 PM

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  • HAL Id : tel-00275793, version 1

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Brigitte Bonan-Hayat. Sécurisation du circuit des chimiothérapies en établissement hospitalier :application à la production des médicaments anticancéreux. Sciences de l'ingénieur [physics]. Ecole Centrale Paris, 2007. Français. ⟨tel-00275793⟩

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