Synthèse de nouveaux vecteurs peptidiques pour la thérapie anticancéreuse et l'imagerie tumorale

Abstract : Current research on cancer focuses on “targeted strategies” in order to develop sensitive and powerful diagnostic methods, as well as effective and better tolerated therapies. In this context, our works are devoted to the design of synthetic vectors targeting a cellular receptor, the alphaVbeta3 integrin, which is over-expressed in tumours. This allows the accumulation of drugs or detection elements in tumours. The tool used for the construction of our vectors is a cyclodecapeptide scaffold (RAFT: Regioselectively Addressable Functionalized Template) which presents two independent sides and allows the separation of the vector functions. On one side, the targeting function is provided by multivalent presentation of -RGD- specific ligands for the alphaVbeta3 integrin. The other side of the vector supports the molecules of interest for the delivery of therapeutic agents to limit the proliferation of tumours or detection agents for medical imaging.
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Submitted on : Wednesday, April 23, 2008 - 11:25:21 AM
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Stephanie Foillard. Synthèse de nouveaux vecteurs peptidiques pour la thérapie anticancéreuse et l'imagerie tumorale. Chimie. Université Joseph-Fourier - Grenoble I, 2008. Français. ⟨tel-00275297⟩

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