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Crises Convulsives et Système Nerveux Autonome - Analyse de la Coordination Cardiorespiratoire par des Méthodes Spectrale, Géométrique et Symbolique

Abstract : Since the presentation in 1981 of the study of cardiac fluctuations using spectral analysis by Akselrod, several applications based on this technique were developed, in the clinical field or in research. Two spectral components are extracted from heart rate variability and, according to authors, are related to sympathetic and parasympathetic activities of the autonomic nervous system. However, frequency bands are highly dependent on the ages of the studied subjects and the application of this method must be done under strictly defined conditions and in precise cases. The development of new techniques assessing modulations of the autonomic nervous system activities which could be adapted to different subjects may give the possibility to generalize the study of cardiorespiratory parameters.
In this work, we have put in relation a geometrical analysis of the heart rate with this spectral method and developed another one, based on the symbolic coding of the cardiorespiratory variability. This last method, linked to an estimation of the entropy rate for the determination of an appropriate pattern length, gives a value of the coordination between cardiac and respiratory rhythm.
Applicated to epileptic adolescents treated by vagus nerve stimulation, these three methods showed modifications of the autonomic nervous system activities. Furthermore, in this part, we have demonstrated that the results from the spectral method are unreliable for young subjects while keeping original parameters. Geometrical and symbolic methods were finally used for the study of adults and new-borns with seizures. As recording parameters did not gave the possibility to obtain accurate results on the analysis of autonomic nervous system activities in children, propositions for their improvement were made and future potentially interesting conclusions concerning the development of seizures are awaited.
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Contributor : Mickael Pruvost <>
Submitted on : Tuesday, April 22, 2008 - 9:02:34 PM
Last modification on : Tuesday, April 27, 2021 - 3:11:02 PM
Long-term archiving on: : Friday, May 28, 2010 - 5:03:02 PM

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Mickael Pruvost. Crises Convulsives et Système Nerveux Autonome - Analyse de la Coordination Cardiorespiratoire par des Méthodes Spectrale, Géométrique et Symbolique. Ingénierie biomédicale. Université de Picardie Jules Verne, 2007. Français. ⟨tel-00275235⟩

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