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Structure design and synthesis of Novel Aryl C-Glycosides as PTP-1B or GP inhibitors and their bioactivities

Abstract : Protein tyrosine phosphatase 1B (PTP 1B) and glycogen phosphorylase (GP) are new therapeutic targets of type 2 diabetes and obesity. According to our previous work and aiming to find highly selective and active aryl C glycosides as PTP 1B or GP inhibitors, C glycosyl 1,4 naphthaquinone derivatives, 6 O benzoylated benzoquinone /naphthaquinone C glycosides, quinone derivatives of glycuronic acids and the carboxyl amides as well as the bidentate quinone C glycosyl derivatives were designed and synthesized. In total 178 compounds were prepared. The mechanism and the influence factors of the aryl C glycosylation were also investigated. Preliminary results of in vitro bioactivities test showed that some target compounds exhibited interesting activities which could bc further studied.
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https://tel.archives-ouvertes.fr/tel-00258958
Contributor : Ens Cachan Bibliothèque <>
Submitted on : Tuesday, February 26, 2008 - 10:57:05 AM
Last modification on : Thursday, July 2, 2020 - 5:16:03 PM
Long-term archiving on: : Thursday, May 20, 2010 - 11:35:51 PM

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  • HAL Id : tel-00258958, version 1

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Li Lin. Structure design and synthesis of Novel Aryl C-Glycosides as PTP-1B or GP inhibitors and their bioactivities. Biomolecules [q-bio.BM]. École normale supérieure de Cachan - ENS Cachan, 2007. Chinese. ⟨tel-00258958⟩

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