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Validation des outils immunotoxicologiques pour l'étude des effets biologiques des contaminants du milieu marin

Abstract : Industrial, agricultural, and urban sewages, loaded in various pollutants, draw a chronic ecotoxicological risk on coastal marine ecosystems. For twenty years, the toxic effects of chemicals on the immune system have been studied in all ecological groups, especially in bivalves, to characterize that risk in aquatic ecosystems. To define an operating framework of these immunotoxicological tools, several methodological questions were addressed. Then, was studied the impact of natural endogenous and environmental factors on the immunotoxic signal emitted by a pollutant. Through a French and Canadian framework, two-year surveys in the blue mussel, Mytilus edulis and in the Pacific oyster, Crassostrea gigas, took place in France (Rade de Brest) and gave evidence of the critical role of sex and reproductive cycle on the seasonal patterns of immune parameters, despite the environmental factors of the water column. In the meantime, batches of “in tubo” exposures of blue mussels, in Quebec, at two different seasons, showed also the importance of sex and reproductive cycle in the measurement of the immunotoxic signal, but, most of all, in the immunotoxic sensitivity. Finally, this research built an operating framework for the use of immunotoxicological biomarkers, for chemical risk assessment in coastal marine ecosystems. Furthermore, these findings showed the dramatic role of the studied confounding factors to assess with accuracy the danger of chemicals.
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  • HAL Id : tel-00256657, version 1



Matthieu Duchemin. Validation des outils immunotoxicologiques pour l'étude des effets biologiques des contaminants du milieu marin. Biologie cellulaire. Université de Bretagne occidentale - Brest; Institut National de la Recherche Scientifique, 2007. Français. ⟨tel-00256657⟩



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