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Theses

Ingénierie moléculaire et fluorescence pour la reconnaissance de cations toxiques

Abstract : This work is a part of the “Toxicologie Nucléaire Environnementale” program which aims at studying the effects on the living of heavy metals or radionuclides involved in nuclear industry. Most particularly, it deals with the design of new fluorescent sensors for the selective detection of Pb2+, Cd2+ and Cs+ in biological media. Several fluorescent calixarenes possessing nitrogen atoms were synthesized and their properties as potential lead sensors were investigated. One of them could be used in experimental conditions close to biological media and new target compounds with amide functional groups were proposed. Many approaches were considered for the design of selective fluorescent sensors for cadmium. On the basis of literature results, many chelating compounds incorporating sulfur atoms were synthesized but showed no significant affinity towards cadmium. On the opposite, compounds functionalized with several pyridin-2'-yl-1,2,3-triazol fluorescent moieties linked to a β- cyclodextrin or a calix[4]arene showed good affinity for cadmium in methanol, but the selectivity was found to be insufficient. In contrast, very satisfying results in terms of both selectivity and sensitivity could be obtained with the commercial calcium sensor Rhod-5N in an aqueous medium at neutral pH. Lastly, micromolar detection limits for the selective detection of caesium were reached in an aqueous medium at neutral pH thanks to a new sulfonated fluorescent calixarene with two appended crown-ethers. An original complexation mechanism was proposed and validated by molecular modelling (DFT)
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https://tel.archives-ouvertes.fr/tel-00255005
Contributor : Ens Cachan Bibliothèque <>
Submitted on : Wednesday, February 13, 2008 - 3:46:01 PM
Last modification on : Monday, February 15, 2021 - 10:51:09 AM
Long-term archiving on: : Thursday, May 20, 2010 - 8:20:26 PM

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  • HAL Id : tel-00255005, version 1

Citation

Vincent Souchon. Ingénierie moléculaire et fluorescence pour la reconnaissance de cations toxiques. Autre. École normale supérieure de Cachan - ENS Cachan, 2007. Français. ⟨tel-00255005⟩

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